| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Robin Hood | - | - | - | $238,180 | 10 | $379,598 | May 12 | United International Pictures | false |
| 2 | Iron Man 2 | - | - | - | $162,759 | 10 | $300,567 | Apr 29 | United International Pictures | false |
| 3 | Clash of the Titans | - | - | - | $147,748 | 9 | $505,075 | Apr 14 | Warner Bros. | false |
| 4 | Prince of Persia: The Sands of Time | - | - | - | $100,006 | 10 | $345,819 | May 26 | Walt Disney Pictures | false |
| 5 | A Nightmare on Elm Street | - | - | - | $93,611 | 9 | $149,076 | May 12 | Warner Bros. | false |
| 6 | Date Night | - | - | - | $86,422 | 5 | $87,962 | May 5 | 20th Century Fox International | false |
| 7 | The Back-up Plan | - | - | - | $66,420 | 5 | $86,148 | May 12 | Sony Pictures Releasing | false |
| 8 | My Name Is Khan | - | - | - | $56,723 | 8 | $517,018 | Feb 17 | 20th Century Fox International | false |
| 9 | How to Train Your Dragon | - | - | - | $42,383 | 8 | $206,943 | Mar 31 | United International Pictures | false |
| 10 | Alice in Wonderland | - | - | - | $35,160 | 4 | $503,454 | Mar 3 | Walt Disney Pictures | false |
| 11 | Cop Out | - | - | - | $34,967 | 5 | $37,605 | May 19 | Warner Bros. | false |
| 12 | The Bounty Hunter | - | - | - | $32,137 | 6 | $234,563 | Mar 24 | Sony Pictures Releasing | false |
| 13 | Brooklyn's Finest | - | - | - | $26,961 | 4 | $26,961 | May 5 | - | false |
| 14 | Avatar | - | - | - | $20,962 | 8 | $2,369,317 | Dec 16 | 20th Century Fox International | false |
| 15 | Shutter Island | - | - | - | $17,592 | 10 | $261,844 | Mar 10 | United International Pictures | false |
| 16 | Remember Me | - | - | - | $17,570 | 5 | $109,369 | Mar 31 | United Motion Pictures | false |
| 17 | The Alphabet Killer | - | - | - | $16,545 | 3 | $26,854 | Apr 28 | United Motion Pictures | false |
| 18 | The Last Song | - | - | - | $15,991 | 3 | $46,322 | Apr 21 | Walt Disney Pictures | false |
| 19 | From Paris with Love | - | - | - | $12,438 | 10 | $181,477 | Mar 10 | - | false |
| 20 | Repo Men | - | - | - | $11,275 | 6 | $23,561 | May 26 | United International Pictures | false |
| 21 | New York | - | - | - | $10,213 | 5 | $21,201 | Apr 28 | United Motion Pictures | false |
| 22 | Daybreakers | - | - | - | $7,779 | 5 | $30,719 | Apr 21 | - | false |
| 23 | The Wolfman | - | - | - | $7,649 | 9 | $183,357 | Feb 24 | United International Pictures | false |
| 24 | Stag Night | - | - | - | $3,849 | 3 | $45,927 | Feb 24 | - | false |
| 25 | Green Zone | - | - | - | $3,293 | 10 | $119,960 | Mar 17 | United International Pictures | false |
| 26 | Pandorum | - | - | - | $1,186 | 5 | $33,447 | Mar 31 | - | false |
| 27 | Valentine's Day | - | - | - | $425 | 5 | $261,047 | Feb 10 | Warner Bros. | false |
| 28 | It's Complicated | - | - | - | $166 | 6 | $120,687 | Feb 3 | United International Pictures | false |
| 29 | Alvin and the Chipmunks: The Squeakquel | - | - | - | $162 | 4 | $150,925 | Dec 23 | 20th Century Fox International | false |
| 30 | The Lovely Bones | - | - | - | $87 | 8 | $28,688 | Mar 24 | United International Pictures | false |
