| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Angels & Demons | - | - | - | $158,893 | 8 | $263,363 | May 13 | Sony Pictures Releasing | false |
| 2 | X-Men Origins: Wolverine | - | - | - | $156,009 | 8 | $209,143 | Apr 29 | 20th Century Fox International | false |
| 3 | Knowing | - | - | - | $137,435 | 8 | $264,358 | Apr 22 | United Motion Pictures | false |
| 4 | Night at the Museum: Battle of the Smithsonian | - | - | - | $83,891 | 8 | $248,342 | May 20 | 20th Century Fox International | false |
| 5 | Duplicity | - | - | - | $70,616 | 8 | $81,989 | May 6 | United International Pictures | false |
| 6 | The Uninvited | - | - | - | $60,812 | 8 | $81,705 | Apr 29 | United International Pictures | false |
| 7 | Fast & Furious | - | - | - | $45,200 | 8 | $243,650 | Apr 8 | United International Pictures | false |
| 8 | State of Play | - | - | - | $36,962 | 6 | $86,835 | May 20 | United International Pictures | false |
| 9 | Friday the 13th | - | - | - | $28,258 | 8 | $56,495 | Apr 22 | United International Pictures | false |
| 10 | Star Trek | - | - | - | $27,664 | 5 | $35,420 | May 13 | United International Pictures | false |
| 11 | Terminator Salvation | - | - | - | $26,141 | - | $26,141 | May 27 | - | false |
| 12 | Push | - | - | - | $25,477 | 5 | $71,981 | Apr 8 | United Motion Pictures | false |
| 13 | Paul Blart: Mall Cop | - | - | - | $25,378 | 8 | $77,578 | Apr 15 | Sony Pictures Releasing | false |
| 14 | It's Alive | - | - | - | $23,777 | 5 | $23,936 | May 6 | - | false |
| 15 | Hannah Montana: The Movie | - | - | - | $21,186 | 4 | $67,815 | Apr 8 | Walt Disney Pictures | false |
| 16 | House | - | - | - | $19,444 | 5 | $130,953 | Mar 18 | - | false |
| 17 | Crossing Over | - | - | - | $16,813 | 5 | $46,417 | Apr 15 | - | false |
| 18 | The Curious Case of Benjamin Button | - | - | - | $13,589 | 8 | $385,605 | Feb 18 | Warner Bros. | false |
| 19 | Taken | - | - | - | $11,106 | 6 | $164,076 | Mar 4 | - | false |
| 20 | 12 Rounds | - | - | - | $10,541 | 5 | $76,607 | Apr 1 | 20th Century Fox International | false |
| 21 | The Unborn | - | - | - | $10,486 | 8 | $110,822 | Mar 25 | United International Pictures | false |
| 22 | Marley & Me | - | - | - | $5,483 | 8 | $134,871 | Mar 4 | 20th Century Fox International | false |
| 23 | Monsters vs. Aliens | - | - | - | $4,479 | 8 | $57,227 | Apr 1 | United International Pictures | false |
| 24 | Dragonball Evolution | - | - | - | $3,670 | 5 | $16,712 | Apr 15 | 20th Century Fox International | false |
| 25 | Asterix at the Olympic Games | - | - | - | $510 | 1 | $510 | May 6 | - | false |
| 26 | Watchmen | - | - | - | $345 | 8 | $90,697 | Mar 11 | United International Pictures | false |
| 27 | Outlander | - | - | - | $211 | 5 | $47,811 | Mar 25 | United Motion Pictures | false |
| 28 | WALL·E | - | - | - | $174 | 1 | $37,253 | Aug 6 | Walt Disney Pictures | false |
| 29 | Revolutionary Road | - | - | - | $101 | 6 | $70,278 | Feb 25 | United International Pictures | false |
