| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Star Trek | - | - | - | $209,313,884 | 4,053 | $257,730,019 | May 8 | Paramount Pictures | false |
| 2 | X-Men Origins: Wolverine | - | - | - | $170,843,712 | 4,102 | $179,883,157 | May 1 | Twentieth Century Fox | false |
| 3 | Angels & Demons | - | - | - | $104,913,439 | 3,527 | $133,375,846 | May 15 | Sony Pictures Releasing | false |
| 4 | Night at the Museum: Battle of the Smithsonian | - | - | - | $104,150,268 | 4,101 | $177,243,721 | May 22 | Twentieth Century Fox | false |
| 5 | Terminator Salvation | - | - | - | $90,949,924 | 3,602 | $125,322,469 | May 21 | Warner Bros. | false |
| 6 | Up | - | - | - | $68,108,790 | 3,886 | $293,004,164 | May 29 | Walt Disney Studios Motion Pictures | false |
| 7 | Ghosts of Girlfriends Past | - | - | - | $50,021,779 | 3,175 | $55,250,026 | May 1 | Warner Bros. | false |
| 8 | Obsessed | - | - | - | $32,698,147 | 2,634 | $68,261,644 | Apr 24 | Screen Gems | false |
| 9 | 17 Again | - | - | - | $19,091,431 | 3,255 | $64,167,069 | Apr 17 | Warner Bros. | false |
| 10 | Dance Flick | - | - | - | $19,084,907 | 2,459 | $25,662,155 | May 22 | Paramount Pictures | false |
| 11 | Monsters vs. Aliens | - | - | - | $17,817,322 | 4,136 | $198,351,526 | Mar 27 | DreamWorks | false |
| 12 | The Soloist | - | - | - | $17,743,485 | 2,090 | $31,720,158 | Apr 24 | DreamWorks | false |
| 13 | Drag Me to Hell | - | - | - | $15,825,480 | 2,510 | $42,100,625 | May 29 | Universal Pictures | false |
| 14 | Earth | - | - | - | $13,339,315 | 1,804 | $32,011,576 | Apr 22 | Walt Disney Studios Motion Pictures | false |
| 15 | Hannah Montana: The Movie | - | - | - | $10,583,745 | 3,231 | $79,576,189 | Apr 10 | Walt Disney Studios Motion Pictures | false |
| 16 | Fighting | - | - | - | $9,548,570 | 2,312 | $23,091,010 | Apr 24 | Universal Pictures | false |
| 17 | Next Day Air | - | - | - | $9,479,286 | 1,139 | $10,027,047 | May 8 | Summit Entertainment | false |
| 18 | State of Play | - | - | - | $9,338,250 | 2,807 | $37,017,955 | Apr 17 | Universal Pictures | false |
| 19 | Fast & Furious | - | - | - | $6,903,475 | 3,674 | $155,064,265 | Apr 3 | Universal Pictures | false |
| 20 | I Love You, Man | - | - | - | $2,776,737 | 2,829 | $71,440,011 | Mar 20 | DreamWorks | false |
| 21 | Under the Sea 3D | - | - | - | $2,295,402 | 108 | $36,262,926 | Feb 13 | Warner Bros. | false |
| 22 | Taken | - | - | - | $2,138,938 | 3,184 | $145,000,989 | Jan 30 | Twentieth Century Fox | false |
| 23 | Knowing | - | - | - | $2,030,350 | 3,337 | $79,957,634 | Mar 20 | Summit Entertainment | false |
| 24 | Sunshine Cleaning | - | - | - | $1,664,274 | 642 | $12,062,558 | Mar 13 | Overture Films | false |
| 25 | Battle for Terra | - | - | - | $1,618,688 | 1,159 | $1,647,083 | May 1 | Lionsgate | false |
| 26 | Is Anybody There? | - | - | - | $1,526,609 | 165 | $2,026,756 | Apr 17 | - | false |
| 27 | Rudo y Cursi | - | - | - | $1,385,068 | 219 | $1,827,660 | May 8 | Sony Pictures Classics | false |
| 28 | The Brothers Bloom | - | - | - | $1,360,130 | 209 | $3,531,756 | May 15 | Summit Entertainment | false |
| 29 | Race to Witch Mountain | - | - | - | $1,198,526 | 3,268 | $67,172,594 | Mar 13 | Walt Disney Studios Motion Pictures | false |
| 30 | Paul Blart: Mall Cop | - | - | - | $1,108,322 | 3,206 | $146,336,178 | Jan 16 | Sony Pictures Releasing | false |
| 31 | Observe and Report | - | - | - | $915,221 | 2,727 | $24,007,324 | Apr 10 | Warner Bros. | false |
| 32 | Crank: High Voltage | - | - | - | $879,044 | 2,223 | $13,684,249 | Apr 17 | Lionsgate | false |
| 33 | Gran Torino | - | - | - | $808,822 | 3,045 | $148,095,302 | Dec 12 | Warner Bros. | false |
| 34 | Sin Nombre | - | - | - | $793,851 | 87 | $2,536,665 | Mar 20 | Focus Features | false |
| 35 | Management | - | - | - | $786,276 | 212 | $934,658 | May 15 | The Samuel Goldwyn Company | false |
| 36 | The Haunting in Connecticut | - | - | - | $774,844 | 2,732 | $55,389,516 | Mar 27 | Lionsgate | false |
| 37 | 12 Rounds | - | - | - | $695,122 | 2,331 | $12,234,694 | Mar 27 | Twentieth Century Fox | false |
| 38 | Every Little Step | - | - | - | $694,056 | 70 | $1,725,141 | Apr 17 | Sony Pictures Classics | false |
| 39 | Adventureland | - | - | - | $683,516 | 1,876 | $16,044,025 | Apr 3 | Miramax | false |
| 40 | Valentino: The Last Emperor | - | - | - | $553,941 | 38 | $1,755,134 | Mar 18 | Truly Indie | false |
| 41 | Duplicity | - | - | - | $552,830 | 2,579 | $40,572,825 | Mar 20 | Universal Pictures | false |
| 42 | Tyson | - | - | - | $542,228 | 56 | $887,918 | Apr 24 | Sony Pictures Classics | false |
| 43 | Dragonball Evolution | - | - | - | $531,672 | 2,181 | $9,362,785 | Apr 10 | Twentieth Century Fox | false |
| 44 | Summer Hours | - | - | - | $480,645 | 50 | $1,657,001 | May 15 | IFC Films | false |
| 45 | Hotel for Dogs | - | - | - | $397,392 | 3,271 | $73,034,460 | Jan 16 | DreamWorks | false |
| 46 | Sugar | - | - | - | $392,748 | 51 | $1,082,124 | Apr 3 | Sony Pictures Classics | false |
| 47 | Watchmen | - | - | - | $392,583 | 3,611 | $107,509,799 | Mar 6 | Warner Bros. | false |
| 48 | The Girlfriend Experience | - | - | - | $321,549 | 48 | $695,840 | May 22 | Magnolia Pictures | false |
| 49 | The Limits of Control | - | - | - | $316,339 | 27 | $426,688 | May 1 | Focus Features | false |
| 50 | Anvil: The Story of Anvil | - | - | - | $315,262 | 27 | $667,911 | Apr 10 | Abramorama | false |
| 51 | Goodbye Solo | - | - | - | $299,212 | 34 | $870,781 | Mar 27 | Roadside Attractions | false |
| 52 | Magnificent Desolation: Walking on the Moon | - | - | - | $288,266 | 82 | $34,137,524 | Sep 23 | IMAX | false |
| 53 | Easy Virtue | - | - | - | $274,420 | 255 | $2,656,784 | May 22 | Sony Pictures Classics | false |
| 54 | Lemon Tree | - | - | - | $264,588 | 29 | $569,672 | Apr 17 | IFC Films | false |
| 55 | He's Just Not That Into You | - | - | - | $256,087 | 3,175 | $93,953,653 | Feb 6 | Warner Bros. | false |
| 56 | Paris 36 | - | - | - | $250,730 | 52 | $851,540 | Apr 3 | Sony Pictures Classics | false |
| 57 | Confessions of a Shopaholic | - | - | - | $241,231 | 2,534 | $44,277,350 | Feb 13 | Walt Disney Studios Motion Pictures | false |
| 58 | The Merry Gentleman | - | - | - | $241,128 | 33 | $347,977 | May 1 | The Samuel Goldwyn Company | false |
| 59 | Little Ashes | - | - | - | $240,923 | 16 | $481,586 | May 8 | Regent Releasing | false |
| 60 | Coraline | - | - | - | $238,943 | 2,320 | $75,286,229 | Feb 6 | Focus Features | false |
| 61 | The Last House on the Left | - | - | - | $238,595 | 2,402 | $32,752,215 | Mar 13 | Universal Pictures | false |
| 62 | Space Station 3D | - | - | - | $232,342 | 64 | $93,383,953 | Apr 19 | IMAX | false |
| 63 | Dolphins and Whales 3D: Tribes of the Ocean | - | - | - | $218,054 | 42 | $7,714,996 | Feb 15 | 3D Entertainment | false |
| 64 | Lymelife | - | - | - | $211,569 | 35 | $421,307 | Apr 8 | Screen Media Films | false |
| 65 | Fly Me to the Moon 3D | - | - | - | $189,587 | 713 | $13,816,982 | Aug 15 | Summit Entertainment | false |
| 66 | Two Lovers | - | - | - | $162,971 | 148 | $3,149,034 | Feb 13 | Magnolia Pictures | false |
| 67 | Adoration | - | - | - | $159,423 | 20 | $294,244 | May 8 | Sony Pictures Classics | false |
| 68 | Outrage | - | - | - | $155,809 | 18 | $287,198 | May 8 | Magnolia Pictures | false |
| 69 | American Violet | - | - | - | $147,647 | 61 | $554,434 | Apr 17 | The Samuel Goldwyn Company | false |
| 70 | Shall We Kiss? | - | - | - | $143,248 | 33 | $535,499 | Mar 27 | Music Box Films | false |
| 71 | Sea Monsters: A Prehistoric Adventure | - | - | - | $138,051 | 252 | $23,746,066 | Oct 5 | National Geographic Entertainment | false |
| 72 | Il Divo | - | - | - | $119,273 | 8 | $240,159 | Apr 24 | Music Box Films | false |
| 73 | Slumdog Millionaire | - | - | - | $113,571 | 2,943 | $141,319,928 | Nov 12 | - | false |
| 74 | Everlasting Moments | - | - | - | $106,681 | 30 | $610,825 | Mar 6 | IFC Films | false |
| 75 | The Class | - | - | - | $102,787 | 126 | $3,766,810 | Dec 19 | Sony Pictures Classics | false |
| 76 | Gomorrah | - | - | - | $98,427 | 50 | $1,579,146 | Dec 19 | IFC Films | false |
| 77 | Revanche | - | - | - | $96,619 | 10 | $258,388 | May 1 | Janus Films | false |
| 78 | Enlighten Up! | - | - | - | $77,105 | 12 | $246,649 | Sep 12 | Balcony Releasing | false |
| 79 | Stomp! Shout! Scream! | - | - | - | $74,389 | 8 | $112,791 | Apr 10 | Indican Pictures | false |
| 80 | U2 3D | - | - | - | $70,684 | 686 | $10,363,341 | Jan 23 | National Geographic Entertainment | false |
| 81 | The Great Buck Howard | - | - | - | $70,480 | 76 | $750,587 | Mar 20 | Magnolia Pictures | false |
| 82 | Roving Mars | - | - | - | $67,943 | 27 | $10,407,978 | Jan 27 | Walt Disney Studios Motion Pictures | false |
| 83 | Push | - | - | - | $64,737 | 2,313 | $31,811,527 | Feb 6 | Summit Entertainment | false |
| 84 | Not Forgotten | - | - | - | $51,932 | 4 | $53,744 | May 1 | Anchor Bay Films | false |
| 85 | O'Horten | - | - | - | $50,534 | 23 | $302,232 | May 22 | Sony Pictures Classics | false |
| 86 | The Cross | - | - | - | $50,067 | 221 | $741,557 | Mar 27 | 8x Entertainment | false |
| 87 | Love N' Dancing | - | - | - | $46,933 | 35 | $47,812 | May 8 | Screen Media Films | false |
| 88 | Departures | - | - | - | $44,973 | 27 | $1,498,210 | May 29 | Regent Releasing | false |
| 89 | Tokyo! | - | - | - | $44,138 | 18 | $351,059 | Mar 6 | Liberation Entertainment | false |
| 90 | Brothers at War | - | - | - | $38,757 | 18 | $153,148 | Mar 13 | The Samuel Goldwyn Company | false |
| 91 | Julia | - | - | - | $37,148 | 4 | $65,108 | May 8 | Magnolia Pictures | false |
| 92 | Tulpan | - | - | - | $36,065 | 4 | $158,741 | Apr 1 | Zeitgeist Films | false |
| 93 | Rolling | - | - | - | $35,833 | 4 | $103,318 | Apr 3 | Indican Pictures | false |
| 94 | Gigantic | - | - | - | $35,258 | 11 | $102,704 | Apr 3 | First Independent Pictures | false |
| 95 | Tokyo Sonata | - | - | - | $33,977 | 10 | $278,356 | Mar 13 | Regent Releasing | false |
| 96 | The Boys | - | - | - | $31,883 | 5 | $55,513 | May 22 | Walt Disney Studios Motion Pictures | false |
| 97 | Treeless Mountain | - | - | - | $27,221 | 4 | $60,336 | Apr 22 | Oscilloscope | false |
| 98 | Fados | - | - | - | $27,122 | 6 | $129,150 | Mar 6 | Zeitgeist Films | false |
| 99 | The Reader | - | - | - | $26,999 | 1,203 | $34,194,407 | Dec 10 | The Weinstein Company | false |
| 100 | Hunger | - | - | - | $22,307 | 11 | $154,084 | Dec 5 | IFC Films | false |
| 101 | Three Monkeys | - | - | - | $21,700 | 3 | $41,343 | Mar 27 | Zeitgeist Films | false |
| 102 | Examined Life | - | - | - | $21,570 | 6 | $120,712 | Feb 25 | Zeitgeist Films | false |
| 103 | Jerichow | - | - | - | $20,963 | 3 | $60,379 | May 15 | The Cinema Guild | false |
| 104 | 12 | - | - | - | $20,621 | 20 | $125,120 | Mar 4 | Sony Pictures Classics | false |
| 105 | Harvard Beats Yale 29-29 | - | - | - | $20,447 | 13 | $268,431 | Nov 19 | Kino International | false |
| 106 | The Garden | - | - | - | $19,985 | 4 | $26,931 | Apr 24 | Oscilloscope | false |
| 107 | Che: Part One/Che: Part Two | - | - | - | $19,596 | 39 | $1,497,109 | Dec 12 | IFC Films | false |
| 108 | The Legend of God's Gun | - | - | - | $18,998 | 8 | $243,768 | Jul 18 | Indican Pictures | false |
| 109 | The Wrestler | - | - | - | $17,027 | 776 | $26,238,243 | Dec 17 | - | false |
| 110 | Big Man Japan 2008 Re-release | - | - | - | $16,472 | 5 | $40,796 | May 15 | Magnolia Pictures | false |
| 111 | Burma VJ: Reporting from a Closed Country | - | - | - | $16,387 | 3 | $51,672 | May 20 | Oscilloscope | false |
| 112 | Street Fighter: The Legend of Chun-Li | - | - | - | $15,784 | 1,164 | $8,742,261 | Feb 27 | Twentieth Century Fox | false |
| 113 | The Song of Sparrows | - | - | - | $15,668 | 5 | $116,372 | Apr 3 | Regent Releasing | false |
| 114 | A Wink and a Smile | - | - | - | $14,278 | 4 | $20,169 | May 1 | First Run | false |
| 115 | Skills Like This | - | - | - | $13,848 | 7 | $63,163 | Mar 20 | Shadow Distribution | false |
| 116 | Galapagos | - | - | - | $13,273 | 14 | $18,630,372 | Oct 29 | IMAX | false |
| 117 | In a Dream | - | - | - | $11,864 | 4 | $54,640 | Apr 10 | International Film Circuit | false |
| 118 | Katyn | - | - | - | $11,551 | 2 | $118,095 | Feb 18 | Koch Lorber Films | false |
| 119 | Ballerina | - | - | - | $10,921 | 5 | $114,507 | Jan 16 | First Run | false |
| 120 | Kabei: Our Mother | - | - | - | $10,824 | 1 | $14,416 | May 8 | Strand Releasing | false |
| 121 | Pressure Cooker | - | - | - | $10,776 | 2 | $44,803 | May 27 | - | false |
| 122 | Play the Game | - | - | - | $9,919 | 55 | $659,483 | Feb 27 | Slowhand Cinema Releasing | false |
| 123 | Z | - | - | - | $9,877 | 2 | $83,305 | Mar 13 | Rialto Pictures | false |
| 124 | Nursery University | - | - | - | $9,592 | 4 | $26,042 | Apr 24 | Variance Films | false |
| 125 | Cherry Blossoms | - | - | - | $9,155 | 8 | $104,589 | Jan 16 | Strand Releasing | false |
| 126 | Throw Down Your Heart | - | - | - | $8,940 | 4 | $89,521 | Mar 13 | Argot Pictures | false |
| 127 | Bride Wars | - | - | - | $8,340 | 3,228 | $58,715,510 | Jan 9 | Twentieth Century Fox | false |
| 128 | Waltz with Bashir | - | - | - | $7,651 | 208 | $2,283,849 | Dec 25 | Sony Pictures Classics | false |
| 129 | The Skeptic | - | - | - | $6,671 | 2 | $6,671 | May 1 | IFC Films | false |
| 130 | Coyote County Loser | - | - | - | $4,981 | 2 | $24,375 | Mar 20 | Roebuck Media | false |
| 131 | Home | - | - | - | $4,643 | 3 | $9,478 | Apr 23 | Monterey Media | false |
| 132 | The Death Factory Bloodletting | - | - | - | $4,638 | 1 | $4,638 | May 15 | Nocturnal Features | false |
| 133 | The New Twenty | - | - | - | $4,586 | 1 | $17,625 | Mar 20 | Argot Pictures | false |
| 134 | The Golden Boys | - | - | - | $4,154 | 20 | $43,600 | Apr 17 | Roadside Attractions | false |
| 135 | The Wild Child | - | - | - | $3,837 | 2 | $65,051 | Nov 7 | The Film Desk | false |
| 136 | One Day You'll Understand | - | - | - | $3,510 | 7 | $145,642 | Oct 31 | Kino International | false |
| 137 | Sleep Dealer | - | - | - | $3,121 | 18 | $80,136 | Apr 17 | Maya Entertainment | false |
| 138 | Absurdistan | - | - | - | $3,105 | 3 | $39,683 | Feb 6 | First Run | false |
| 139 | Alien Trespass | - | - | - | $2,662 | 40 | $104,526 | Apr 3 | Roadside Attractions | false |
| 140 | Our City Dreams | - | - | - | $2,240 | 3 | $34,972 | Feb 6 | First Run | false |
| 141 | Made in U.S.A | - | - | - | $1,897 | 2 | $95,209 | Jan 9 | Rialto Pictures | false |
| 142 | Of Time and the City | - | - | - | $1,889 | 2 | $32,677 | Jan 21 | Strand Releasing | false |
| 143 | Unmistaken Child | - | - | - | $1,470 | 6 | $306,140 | Jun 3 | Oscilloscope | false |
| 144 | The Mysteries of Pittsburgh | - | - | - | $1,317 | 20 | $80,283 | Apr 10 | - | false |
| 145 | Pontypool | - | - | - | $1,281 | 1 | $3,865 | May 29 | IFC Films | false |
| 146 | Service | - | - | - | $537 | 4 | $64,536 | Jan 30 | Regent Releasing | false |
| 147 | A Secret | - | - | - | $409 | 11 | $623,558 | Sep 5 | Strand Releasing | false |
| 148 | Laila's Birthday | - | - | - | $81 | 3 | $13,689 | May 29 | Kino International | false |
