| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Alice in Wonderland | - | - | - | $385,231 | 11 | $509,177 | Mar 5 | Walt Disney Pictures | false |
| 2 | Avatar | - | - | - | $118,208 | 11 | $1,274,650 | Dec 18 | 20th Century Fox International | false |
| 3 | How to Train Your Dragon | - | - | - | $77,627 | 10 | $212,859 | Mar 26 | Paramount Pictures International | false |
| 4 | Edge of Darkness | - | - | - | $77,544 | 7 | $127,710 | Feb 26 | Warner Bros. | false |
| 5 | The Widows of Thursdays | - | - | - | $59,272 | 7 | $74,737 | Mar 5 | - | false |
| 6 | The Book of Eli | - | - | - | $58,698 | 5 | $106,178 | Mar 19 | Sony Pictures Releasing | false |
| 7 | The Blind Side | - | - | - | $57,835 | 4 | $76,906 | Mar 5 | Warner Bros. | false |
| 8 | Did You Hear About the Morgans? | - | - | - | $55,053 | 5 | $77,261 | Feb 26 | Sony Pictures Releasing | false |
| 9 | The Hurt Locker | - | - | - | $43,515 | 4 | $88,196 | Feb 5 | - | false |
| 10 | The Bounty Hunter | - | - | - | $37,172 | 5 | $122,335 | Mar 26 | Sony Pictures Releasing | false |
| 11 | La despedida | - | - | - | $32,525 | 5 | $102,717 | Mar 26 | - | false |
| 12 | Couples Retreat | - | - | - | $31,177 | 6 | $33,593 | Mar 12 | Universal Pictures International (UPI) | false |
| 13 | Tooth Fairy | - | - | - | $29,052 | 5 | $73,077 | Feb 26 | 20th Century Fox International | false |
| 14 | An Education | - | - | - | $22,030 | 4 | $60,876 | Feb 19 | Sony Pictures Releasing | false |
| 15 | Nine | - | - | - | $21,819 | 3 | $21,819 | Mar 5 | Sony Pictures Releasing | false |
| 16 | A Serious Man | - | - | - | $15,077 | 1 | $25,622 | Feb 26 | Universal Pictures International (UPI) | false |
| 17 | Two Lovers | - | - | - | $12,569 | 3 | $15,817 | Mar 19 | - | false |
| 18 | Saw VI | - | - | - | $11,775 | 5 | $22,086 | Mar 26 | Walt Disney Pictures | false |
| 19 | Precious | - | - | - | $11,654 | 4 | $46,212 | Feb 12 | - | false |
| 20 | Invictus | - | - | - | $11,425 | 8 | $210,474 | Jan 22 | Warner Bros. | false |
| 21 | Let it Rain | - | - | - | $7,704 | 2 | $15,072 | Mar 19 | - | false |
| 22 | Valentine's Day | - | - | - | $7,591 | 7 | $134,009 | Feb 12 | Warner Bros. | false |
| 23 | The Wolfman | - | - | - | $6,972 | 5 | $57,406 | Feb 12 | Universal Pictures International (UPI) | false |
| 24 | Alvin and the Chipmunks: The Squeakquel | - | - | - | $6,759 | 6 | $175,570 | Jan 1 | 20th Century Fox International | false |
| 25 | Amelia | - | - | - | $6,546 | 2 | $13,334 | Mar 26 | 20th Century Fox International | false |
| 26 | The Girl with the Dragon Tattoo | - | - | - | $4,203 | 4 | $80,876 | Jan 22 | - | false |
| 27 | Cirque du Freak: The Vampire's Assistant | - | - | - | $3,909 | 5 | $4,159 | Mar 19 | Universal Pictures International (UPI) | false |
| 28 | Igor | - | - | - | $3,385 | 3 | $4,663 | Mar 26 | - | false |
| 29 | One Day You'll Understand | - | - | - | $2,579 | 1 | $2,579 | Mar 12 | - | false |
| 30 | The Girl by the Lake 2009 Re-release | - | - | - | $2,517 | 1 | $3,764 | Feb 26 | - | false |
| 31 | Old Dogs | - | - | - | $1,822 | 5 | $137,222 | Jan 22 | Walt Disney Pictures | false |
| 32 | Percy Jackson & the Olympians: The Lightning Thief | - | - | - | $1,508 | 5 | $45,739 | Feb 12 | 20th Century Fox International | false |
| 33 | Easy Virtue | - | - | - | $1,226 | 4 | $31,895 | Jan 29 | Sony Pictures Releasing | false |
| 34 | Sherlock Holmes | - | - | - | $1,164 | 10 | $200,256 | Jan 15 | Warner Bros. | false |
| 35 | Up in the Air | - | - | - | $741 | 8 | $135,536 | Jan 22 | Paramount Pictures International | false |
| 36 | Astro Boy | - | - | - | $53 | 4 | $30,546 | Jan 29 | - | false |
