| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Alice in Wonderland | - | - | - | $285,102 | 4 | $503,454 | Mar 3 | Walt Disney Pictures | false |
| 2 | Avatar | - | - | - | $201,965 | 8 | $2,369,317 | Dec 16 | 20th Century Fox International | false |
| 3 | My Name Is Khan | - | - | - | $199,848 | 8 | $517,018 | Feb 17 | 20th Century Fox International | false |
| 4 | Shutter Island | - | - | - | $152,233 | 10 | $261,844 | Mar 10 | United International Pictures | false |
| 5 | From Paris with Love | - | - | - | $106,404 | 10 | $181,477 | Mar 10 | - | false |
| 6 | The Wolfman | - | - | - | $86,305 | 9 | $183,357 | Feb 24 | United International Pictures | false |
| 7 | Green Zone | - | - | - | $73,556 | 10 | $119,960 | Mar 17 | United International Pictures | false |
| 8 | Valentine's Day | - | - | - | $71,359 | 5 | $261,047 | Feb 10 | Warner Bros. | false |
| 9 | The Bounty Hunter | - | - | - | $54,164 | 6 | $234,563 | Mar 24 | Sony Pictures Releasing | false |
| 10 | The Book of Eli | - | - | - | $42,081 | 8 | $277,990 | Jan 27 | United Motion Pictures | false |
| 11 | Percy Jackson & the Olympians: The Lightning Thief | - | - | - | $34,003 | 8 | $109,326 | Feb 10 | 20th Century Fox International | false |
| 12 | It's Complicated | - | - | - | $30,523 | 6 | $120,687 | Feb 3 | United International Pictures | false |
| 13 | When in Rome | - | - | - | $28,189 | 4 | $52,380 | Mar 17 | Walt Disney Pictures | false |
| 14 | The Children | - | - | - | $26,678 | 4 | $44,088 | Mar 10 | United Motion Pictures | false |
| 15 | Up in the Air | - | - | - | $22,735 | 5 | $76,195 | Feb 10 | United International Pictures | false |
| 16 | Stag Night | - | - | - | $20,368 | 3 | $45,927 | Feb 24 | - | false |
| 17 | The Tournament | - | - | - | $17,687 | 5 | $19,088 | Mar 3 | United Motion Pictures | false |
| 18 | Sherlock Holmes | - | - | - | $16,430 | 8 | $397,088 | Dec 30 | Warner Bros. | false |
| 19 | The Lovely Bones | - | - | - | $11,531 | 8 | $28,688 | Mar 24 | United International Pictures | false |
| 20 | Old Dogs | - | - | - | $7,295 | 4 | $124,036 | Jan 6 | Walt Disney Pictures | false |
| 21 | Alvin and the Chipmunks: The Squeakquel | - | - | - | $5,974 | 4 | $150,925 | Dec 23 | 20th Century Fox International | false |
| 22 | The Princess and the Frog | - | - | - | $5,128 | 3 | $78,838 | Dec 30 | Walt Disney Pictures | false |
| 23 | Did You Hear About the Morgans? | - | - | - | $2,258 | 5 | $61,799 | Jan 27 | Sony Pictures Releasing | false |
| 24 | Triangle | - | - | - | $2,209 | 5 | $61,346 | Feb 3 | - | false |
| 25 | 2012 | - | - | - | $1,702 | 8 | $1,101,387 | Nov 11 | Sony Pictures Releasing | false |
| 26 | Nine | - | - | - | $1,182 | 4 | $74,434 | Jan 20 | - | false |
| 27 | High Lane | - | - | - | $843 | 5 | $22,200 | Jan 27 | - | false |
| 28 | The Box | - | - | - | $370 | 4 | $30,904 | Jan 13 | - | false |
| 29 | The Ugly Duckling and Me! | - | - | - | $335 | 2 | $5,631 | Feb 3 | - | false |
| 30 | Cirque du Freak: The Vampire's Assistant | - | - | - | $113 | 5 | $42,000 | Dec 9 | United International Pictures | false |
