| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Alice in Wonderland | - | - | - | $299,459,690 | 3,739 | $334,191,110 | Mar 5 | Walt Disney Studios Motion Pictures | false |
| 2 | How to Train Your Dragon | - | - | - | $57,883,758 | 4,060 | $217,581,231 | Mar 26 | DreamWorks | false |
| 3 | Shutter Island | - | - | - | $46,077,365 | 3,356 | $128,012,934 | Feb 19 | Paramount Pictures | false |
| 4 | The Bounty Hunter | - | - | - | $41,617,393 | 3,118 | $67,061,228 | Mar 19 | Sony Pictures Releasing | false |
| 5 | Diary of a Wimpy Kid | - | - | - | $39,469,281 | 3,083 | $64,003,625 | Mar 19 | Twentieth Century Fox | false |
| 6 | Avatar | - | - | - | $34,579,935 | 3,461 | $749,766,139 | Dec 18 | Twentieth Century Fox | false |
| 7 | Green Zone | - | - | - | $31,549,470 | 3,004 | $35,053,660 | Mar 12 | Universal Pictures | false |
| 8 | She's Out of My League | - | - | - | $26,783,009 | 2,958 | $32,010,860 | Mar 12 | Paramount Pictures | false |
| 9 | Brooklyn's Finest | - | - | - | $26,491,906 | 1,939 | $27,163,593 | Mar 5 | Overture Films | false |
| 10 | Cop Out | - | - | - | $25,519,663 | 3,150 | $44,875,481 | Feb 26 | Warner Bros. | false |
| 11 | The Crazies | - | - | - | $21,839,831 | 2,479 | $39,123,589 | Feb 26 | Overture Films | false |
| 12 | Hot Tub Time Machine | - | - | - | $18,418,318 | 2,771 | $50,287,556 | Mar 26 | Metro-Goldwyn-Mayer (MGM) | false |
| 13 | Remember Me | - | - | - | $17,610,682 | 2,215 | $19,068,240 | Mar 12 | Summit Entertainment | false |
| 14 | Our Family Wedding | - | - | - | $17,584,148 | 1,609 | $20,255,281 | Mar 12 | - | false |
| 15 | Percy Jackson & the Olympians: The Lightning Thief | - | - | - | $15,305,853 | 3,396 | $88,768,303 | Feb 12 | Twentieth Century Fox | false |
| 16 | Crazy Heart | - | - | - | $12,960,217 | 1,361 | $39,464,306 | Dec 16 | - | false |
| 17 | Repo Men | - | - | - | $12,329,935 | 2,521 | $13,794,835 | Mar 19 | Universal Pictures | false |
| 18 | Valentine's Day | - | - | - | $9,988,450 | 3,665 | $110,485,654 | Feb 12 | Warner Bros. | false |
| 19 | The Ghost Writer | - | - | - | $8,685,038 | 819 | $15,541,549 | Feb 19 | Summit Entertainment | false |
| 20 | Dear John | - | - | - | $6,985,064 | 3,062 | $80,014,842 | Feb 5 | Screen Gems | false |
| 21 | The Blind Side | - | - | - | $6,460,468 | 3,407 | $255,959,475 | Nov 20 | Warner Bros. | false |
| 22 | The Last Song | - | - | - | $5,125,103 | 2,794 | $62,950,384 | Mar 31 | Walt Disney Studios Motion Pictures | false |
| 23 | The Wolfman | - | - | - | $4,589,000 | 3,223 | $61,979,680 | Feb 12 | Universal Pictures | false |
| 24 | Tooth Fairy | - | - | - | $4,503,179 | 3,345 | $60,022,256 | Jan 22 | Twentieth Century Fox | false |
| 25 | The Last Station | - | - | - | $3,079,897 | 354 | $6,617,867 | Jan 15 | Sony Pictures Classics | false |
| 26 | The Hurt Locker | - | - | - | $2,705,895 | 535 | $17,017,811 | Jun 26 | Summit Entertainment | false |
| 27 | Alvin and the Chipmunks: The Squeakquel | - | - | - | $2,575,397 | 3,747 | $219,614,612 | Dec 23 | Twentieth Century Fox | false |
| 28 | Clash of the Titans | - | - | - | $2,275,716 | 3,802 | $163,214,888 | Apr 2 | Warner Bros. | false |
| 29 | Sherlock Holmes | - | - | - | $2,084,424 | 3,626 | $209,028,679 | Dec 25 | Warner Bros. | false |
| 30 | The Runaways | - | - | - | $1,739,664 | 244 | $3,573,673 | Mar 19 | Apparition | false |
| 31 | Up in the Air | - | - | - | $1,711,172 | 2,218 | $83,823,381 | Dec 4 | Paramount Pictures | false |
| 32 | The Book of Eli | - | - | - | $1,551,092 | 3,111 | $94,835,059 | Jan 15 | Warner Bros. | false |
| 33 | Greenberg | - | - | - | $1,478,894 | 186 | $4,234,170 | Mar 19 | Focus Features | false |
| 34 | When in Rome | - | - | - | $1,416,828 | 2,456 | $32,680,633 | Jan 29 | Walt Disney Studios Motion Pictures | false |
| 35 | Hubble | - | - | - | $1,406,500 | 151 | $52,522,904 | Mar 19 | Warner Bros. | false |
| 36 | The Princess and the Frog | - | - | - | $1,326,505 | 3,475 | $104,400,899 | Nov 25 | Walt Disney Studios Motion Pictures | false |
| 37 | A Prophet | - | - | - | $1,260,871 | 83 | $2,087,720 | Feb 26 | Sony Pictures Classics | false |
| 38 | It's Complicated | - | - | - | $1,214,440 | 2,955 | $112,735,375 | Dec 25 | Universal Pictures | false |
| 39 | An Education | - | - | - | $1,117,436 | 763 | $12,574,914 | Oct 9 | Sony Pictures Classics | false |
| 40 | A Single Man | - | - | - | $1,108,528 | 354 | $9,176,000 | Dec 11 | The Weinstein Company | false |
| 41 | Chloe | - | - | - | $1,100,754 | 350 | $3,075,255 | Mar 26 | Sony Pictures Classics | false |
| 42 | Edge of Darkness | - | - | - | $1,068,607 | 3,066 | $43,313,890 | Jan 29 | Warner Bros. | false |
| 43 | The Girl with the Dragon Tattoo | - | - | - | $912,200 | 202 | $10,095,170 | Mar 19 | Music Box Films | false |
| 44 | Old Dogs | - | - | - | $857,959 | 3,425 | $49,492,060 | Nov 25 | Walt Disney Studios Motion Pictures | false |
| 45 | From Paris with Love | - | - | - | $752,761 | 2,722 | $24,077,427 | Feb 5 | Lionsgate | false |
| 46 | The Young Victoria | - | - | - | $650,810 | 476 | $11,001,272 | Dec 18 | Apparition | false |
| 47 | Under the Sea 3D | - | - | - | $622,040 | 108 | $36,262,926 | Feb 13 | Warner Bros. | false |
| 48 | The Twilight Saga: New Moon | - | - | - | $610,243 | 4,124 | $296,623,634 | Nov 20 | Summit Entertainment | false |
| 49 | Legion | - | - | - | $603,075 | 2,476 | $40,168,080 | Jan 22 | Screen Gems | false |
| 50 | The White Ribbon | - | - | - | $601,219 | 106 | $2,222,862 | Dec 30 | Sony Pictures Classics | false |
| 51 | The Lovely Bones | - | - | - | $521,866 | 2,638 | $44,114,232 | Dec 11 | DreamWorks | false |
| 52 | The Oscar Nominated Short Films 2010: Live Action | - | - | - | $462,402 | 95 | $1,018,169 | Feb 19 | Shorts International | false |
| 53 | Precious | - | - | - | $456,899 | 1,003 | $47,566,524 | Nov 6 | Lionsgate | false |
| 54 | Invictus | - | - | - | $378,405 | 2,170 | $37,491,364 | Dec 11 | Warner Bros. | false |
| 55 | To Save a Life | - | - | - | $363,361 | 441 | $3,777,210 | Jan 22 | The Samuel Goldwyn Company | false |
| 56 | My Name Is Khan | - | - | - | $360,291 | 125 | $4,018,771 | Feb 12 | - | false |
| 57 | Magnificent Desolation: Walking on the Moon | - | - | - | $331,068 | 82 | $34,137,524 | Sep 23 | IMAX | false |
| 58 | The Art of the Steal | - | - | - | $295,500 | 34 | $544,890 | Feb 26 | IFC Films | false |
| 59 | Planet 51 | - | - | - | $288,654 | 3,035 | $42,194,060 | Nov 20 | Sony Pictures Releasing | false |
| 60 | Space Station 3D | - | - | - | $266,382 | 64 | $93,383,953 | Apr 19 | IMAX | false |
| 61 | Mother | - | - | - | $240,099 | 38 | $551,509 | Mar 12 | Magnolia Pictures | false |
| 62 | North Face | - | - | - | $236,075 | 36 | $711,421 | Jan 29 | Music Box Films | false |
| 63 | Ajami | - | - | - | $225,155 | 23 | $622,403 | Feb 3 | Kino International | false |
| 64 | Karthik Calling Karthik | - | - | - | $197,159 | 70 | $286,409 | Feb 26 | Eros Worldwide | false |
| 65 | The Imaginarium of Doctor Parnassus | - | - | - | $196,326 | 607 | $7,689,607 | Dec 25 | Sony Pictures Classics | false |
| 66 | The Yellow Handkerchief | - | - | - | $177,795 | 29 | $318,623 | Feb 26 | The Samuel Goldwyn Company | false |
| 67 | Broken Embraces | - | - | - | $171,715 | 202 | $5,014,305 | Nov 20 | Sony Pictures Classics | false |
| 68 | Dolphins and Whales 3D: Tribes of the Ocean | - | - | - | $165,587 | 42 | $7,714,996 | Feb 15 | 3D Entertainment | false |
| 69 | Fantastic Mr. Fox | - | - | - | $141,512 | 2,304 | $21,002,919 | Nov 13 | Twentieth Century Fox | false |
| 70 | The Most Dangerous Man in America: Daniel Ellsberg and the Pentagon Papers | - | - | - | $139,520 | 12 | $453,993 | Jan 29 | First Run | false |
| 71 | Deep Sea | - | - | - | $136,025 | 47 | $46,412,757 | Mar 3 | Warner Bros. | false |
| 72 | The Messenger | - | - | - | $134,512 | 50 | $1,109,660 | Nov 13 | Oscilloscope | false |
| 73 | Formosa Betrayed | - | - | - | $126,802 | 16 | $225,341 | Feb 26 | Screen Media Films | false |
| 74 | The Secret of Kells | - | - | - | $126,510 | 37 | $676,775 | Mar 5 | GKIDS | false |
| 75 | Sea Monsters: A Prehistoric Adventure | - | - | - | $124,502 | 252 | $23,746,066 | Oct 5 | National Geographic Entertainment | false |
| 76 | City Island | - | - | - | $107,152 | 269 | $6,671,036 | Mar 19 | Anchor Bay Films | false |
| 77 | The Weathered Underground | - | - | - | $105,079 | 22 | $140,091 | Jan 26 | Indican Pictures | false |
| 78 | Vincere | - | - | - | $91,008 | 36 | $619,162 | Mar 19 | IFC Films | false |
| 79 | Youth in Revolt | - | - | - | $77,247 | 1,873 | $15,281,286 | Jan 8 | - | false |
| 80 | The Secrets of Jonathan Sperry | - | - | - | $66,496 | 135 | $1,355,079 | Sep 18 | Five & Two Pictures | false |
| 81 | Fish Tank | - | - | - | $62,581 | 15 | $374,675 | Jan 15 | IFC Films | false |
| 82 | Creation | - | - | - | $62,392 | 12 | $341,323 | Jan 22 | Newmarket Films | false |
| 83 | U2 3D | - | - | - | $56,389 | 686 | $10,363,341 | Jan 23 | National Geographic Entertainment | false |
| 84 | Prodigal Sons | - | - | - | $55,182 | 11 | $73,544 | Feb 26 | First Run | false |
| 85 | Red Riding: The Year of Our Lord 1974 | - | - | - | $54,943 | 9 | $151,644 | Feb 5 | IFC Films | false |
| 86 | Preacher's Kid | - | - | - | $54,896 | 109 | $515,065 | Jan 29 | 8x Entertainment | false |
| 87 | Mid-August Lunch | - | - | - | $51,796 | 23 | $675,299 | Mar 17 | Zeitgeist Films | false |
| 88 | That Evening Sun | - | - | - | $50,167 | 10 | $281,350 | Nov 6 | Freestyle Releasing | false |
| 89 | Nine | - | - | - | $48,320 | 1,412 | $19,676,965 | Dec 18 | The Weinstein Company | false |
| 90 | Waking Sleeping Beauty | - | - | - | $42,108 | 5 | $80,741 | Mar 26 | Walt Disney Studios Motion Pictures | false |
| 91 | The Spy Next Door | - | - | - | $38,278 | 2,924 | $24,307,086 | Jan 15 | Lionsgate | false |
| 92 | The Girl on the Train | - | - | - | $36,442 | 10 | $208,023 | Jan 22 | Strand Releasing | false |
| 93 | Harlan: In the Shadow of Jew Suess | - | - | - | $35,801 | 5 | $54,305 | Mar 3 | Zeitgeist Films | false |
| 94 | The Good Guy | - | - | - | $32,254 | 9 | $100,688 | Feb 19 | Roadside Attractions | false |
| 95 | The Road | - | - | - | $31,566 | 396 | $8,117,000 | Nov 25 | - | false |
| 96 | The Red Baron 2010 Re-release | - | - | - | $31,189 | 19 | $37,189 | Mar 19 | Monterey Media | false |
| 97 | Terribly Happy | - | - | - | $29,786 | 9 | $170,943 | Feb 5 | Oscilloscope | false |
| 98 | A Town Called Panic | - | - | - | $28,932 | 10 | $165,509 | Dec 16 | Zeitgeist Films | false |
| 99 | House | - | - | - | $27,751 | 7 | $209,765 | Jan 15 | Janus Films | false |
| 100 | Leap Year | - | - | - | $25,435 | 2,512 | $25,918,920 | Jan 8 | Universal Pictures | false |
| 101 | Ca$h | - | - | - | $24,603 | 43 | $46,488 | Mar 26 | Roadside Attractions | false |
| 102 | Until the Light Takes Us | - | - | - | $23,305 | 3 | $130,441 | Dec 4 | Variance Films | false |
| 103 | See What I'm Saying: The Deaf Entertainers Documentary | - | - | - | $23,063 | 21 | $118,206 | Mar 19 | Worldplay | false |
| 104 | Sweetgrass | - | - | - | $18,859 | 9 | $207,473 | Jan 6 | The Cinema Guild | false |
| 105 | Red Cliff | - | - | - | $18,597 | 42 | $627,047 | Nov 18 | Magnolia Pictures | false |
| 106 | The Maid | - | - | - | $18,513 | 19 | $576,608 | Oct 16 | Elephant Eye Films | false |
| 107 | The Eclipse | - | - | - | $17,670 | 12 | $133,411 | Mar 26 | Magnolia Pictures | false |
| 108 | La Danse: The Paris Opera Ballet | - | - | - | $17,026 | 25 | $567,493 | Nov 4 | Zipporah Films | false |
| 109 | Frozen | - | - | - | $16,974 | 106 | $246,176 | Feb 5 | Anchor Bay Films | false |
| 110 | Mystery Team | - | - | - | $15,393 | 4 | $89,442 | Aug 28 | Roadside Attractions | false |
| 111 | Defendor | - | - | - | $14,560 | 4 | $44,462 | Feb 19 | Darius Films | false |
| 112 | The Exploding Girl | - | - | - | $14,207 | 3 | $25,572 | Mar 12 | Oscilloscope | false |
| 113 | Ran 2010 Re-release | - | - | - | $13,388 | 4 | $124,673 | Feb 5 | Rialto Pictures | false |
| 114 | Lbs. | - | - | - | $12,492 | 1 | $29,866 | Mar 26 | Truly Indie | false |
| 115 | Bluebeard | - | - | - | $11,976 | 3 | $33,490 | Mar 26 | Strand Releasing | false |
| 116 | Children of Invention | - | - | - | $11,183 | 2 | $11,183 | Mar 12 | - | false |
| 117 | The Sun 2009 Re-release | - | - | - | $10,617 | 4 | $77,303 | Nov 18 | Lorber Films | false |
| 118 | Toe to Toe | - | - | - | $9,406 | 2 | $21,648 | Feb 26 | Strand Releasing | false |
| 119 | Bad Lieutenant: Port of Call New Orleans | - | - | - | $7,796 | 96 | $1,702,112 | Nov 20 | First Look International | false |
| 120 | District 13: Ultimatum | - | - | - | $7,568 | 9 | $36,136 | Feb 5 | Magnolia Pictures | false |
| 121 | Tales from the Script | - | - | - | $7,535 | 1 | $7,535 | Mar 12 | First Run | false |
| 122 | The Harimaya Bridge | - | - | - | $6,893 | 3 | $54,473 | Mar 12 | Eleven Arts | false |
| 123 | Dancing Across Borders | - | - | - | $6,564 | 5 | $66,166 | Mar 26 | First Run | false |
| 124 | Stolen | - | - | - | $6,067 | 2 | $7,943 | Mar 12 | IFC Films | false |
| 125 | Dreamkiller | - | - | - | $5,325 | 3 | $15,514 | Feb 19 | Delaware Pictures | false |
| 126 | 35 Shots of Rum | - | - | - | $4,981 | 5 | $177,511 | Sep 16 | The Cinema Guild | false |
| 127 | Seraphine | - | - | - | $4,927 | 24 | $884,613 | Jun 5 | Music Box Films | false |
| 128 | The Yes Men Fix the World | - | - | - | $4,528 | 16 | $194,533 | Sep 25 | Shadow Distribution | false |
| 129 | The Sun Behind the Clouds: Tibet's Struggle for Freedom | - | - | - | $4,446 | 4 | $67,095 | Mar 31 | Balcony Releasing | false |
| 130 | Eyes Wide Open | - | - | - | $4,298 | 1 | $26,258 | Feb 5 | New American Vision | false |
| 131 | Terkel in Trouble 2010 Re-release | - | - | - | $4,284 | 2 | $10,783 | Mar 26 | Indican Pictures | false |
| 132 | Saint John of Las Vegas | - | - | - | $3,992 | 14 | $102,645 | Jan 29 | IndieVest Pictures | false |
| 133 | The Cove | - | - | - | $3,826 | 56 | $857,005 | Jul 31 | Roadside Attractions | false |
| 134 | Small Change | - | - | - | $3,822 | 2 | $38,296 | Nov 24 | The Film Desk | false |
| 135 | 44 Inch Chest 2010 Re-release | - | - | - | $3,562 | 5 | $39,033 | Jan 15 | Image Entertainment | false |
| 136 | The Private Lives of Pippa Lee | - | - | - | $3,344 | 26 | $337,356 | Nov 27 | Screen Media Films | false |
| 137 | Dream Boy | - | - | - | $3,144 | 1 | $6,534 | Mar 26 | Regent Releasing | false |
| 138 | The Flower of Kim Jong II | - | - | - | $3,069 | 1 | $4,362 | Mar 19 | Lorber Films | false |
| 139 | The Korean | - | - | - | $2,973 | 2 | $20,279 | Feb 5 | Indican Pictures | false |
| 140 | The End of Poverty? | - | - | - | $2,941 | 5 | $57,805 | Nov 13 | Cinema Libre Studio | false |
| 141 | 3 Idiots | - | - | - | $2,118 | 156 | $6,532,874 | Dec 23 | Reliance Big Pictures | false |
| 142 | The Wedding Song | - | - | - | $2,098 | 4 | $31,160 | Oct 9 | Strand Releasing | false |
| 143 | White on Rice | - | - | - | $1,985 | 4 | $69,171 | Sep 11 | Variance Films | false |
| 144 | Galapagos | - | - | - | $1,838 | 14 | $18,630,372 | Oct 29 | IMAX | false |
| 145 | Four Seasons Lodge | - | - | - | $1,751 | 3 | $58,334 | Nov 11 | First Run | false |
| 146 | Just Say Love | - | - | - | $1,566 | 1 | $3,944 | Mar 26 | Regent Releasing | false |
| 147 | Killing Kasztner | - | - | - | $1,417 | 5 | $112,313 | Oct 23 | Sky Island Films | false |
| 148 | Under Our Skin | - | - | - | $1,322 | 6 | $98,548 | Jun 19 | Shadow Distribution | false |
| 149 | Yuri Gagarin Conspiracy: Fallen Idol | - | - | - | $1,291 | 2 | $14,471 | Oct 2 | Indican Pictures | false |
| 150 | Home | - | - | - | $1,199 | 2 | $15,925 | Nov 27 | Lorber Films | false |
| 151 | Videocracy | - | - | - | $1,149 | 1 | $23,720 | Feb 12 | Kino International | false |
| 152 | Youssou Ndour: I Bring What I Love | - | - | - | $1,138 | 7 | $172,225 | Jun 12 | Shadow Distribution | false |
| 153 | Off and Running | - | - | - | $908 | 1 | $18,262 | Jan 29 | First Run | false |
| 154 | Happy Tears | - | - | - | $896 | 15 | $22,464 | Feb 19 | Roadside Attractions | false |
| 155 | Manuela and Manuel | - | - | - | $894 | 1 | $1,582 | Mar 26 | Regent Releasing | false |
| 156 | October Country | - | - | - | $871 | 4 | $26,185 | Feb 12 | International Film Circuit | false |
| 157 | The Beaches of Agnès | - | - | - | $805 | 7 | $239,711 | Jul 2 | The Cinema Guild | false |
| 158 | Amreeka | - | - | - | $802 | 40 | $627,436 | Sep 4 | National Geographic Entertainment | false |
| 159 | My Year Without Sex | - | - | - | $792 | 1 | $3,119 | Mar 12 | Strand Releasing | false |
| 160 | 45365 | - | - | - | $655 | 1 | $853 | Feb 26 | - | false |
| 161 | Harmony and Me | - | - | - | $520 | 1 | $20,099 | Sep 18 | - | false |
| 162 | Big Fan | - | - | - | $514 | 15 | $234,540 | Aug 28 | First Independent Pictures | false |
| 163 | Watercolors | - | - | - | $486 | 2 | $6,305 | Jan 22 | Regent Releasing | false |
| 164 | Promised Lands | - | - | - | $480 | 1 | $4,546 | Feb 5 | The Film Desk | false |
| 165 | Le combat dans l'île | - | - | - | $366 | 1 | $50,039 | Jun 12 | The Film Desk | false |
| 166 | Misconceptions | - | - | - | $348 | 2 | $6,892 | Jan 22 | Regent Releasing | false |
| 167 | Monsieur Verdoux | - | - | - | $322 | 2 | $64,636 | Mar 14 | The Film Desk | false |
| 168 | Box Elder | - | - | - | $274 | 2 | $48,996 | Mar 3 | - | false |
| 169 | Beeswax | - | - | - | $253 | 3 | $46,590 | Aug 7 | The Cinema Guild | false |
| 170 | Mississippi Mermaid | - | - | - | $235 | 1 | $33,216 | Jul 10 | The Film Desk | false |
| 171 | Fashion Victim | - | - | - | $228 | 2 | $3,346 | Jan 22 | Regent Releasing | false |
| 172 | The Wild Child | - | - | - | $134 | 2 | $65,051 | Nov 7 | The Film Desk | false |
| 173 | Good Hair | - | - | - | $119 | 466 | $4,157,223 | Oct 9 | Roadside Attractions | false |
