| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | 10,000 BC | - | - | - | $11,851,908 | 475 | $13,119,769 | Mar 7 | Warner Bros. | false |
| 2 | Horton Hears a Who! | - | - | - | $8,482,813 | 476 | $11,301,036 | Mar 14 | 20th Century Fox International | false |
| 3 | Vantage Point | - | - | - | $6,407,677 | 373 | $6,721,872 | Feb 28 | Sony Pictures Releasing | false |
| 4 | 27 Dresses | - | - | - | $6,086,583 | 310 | $6,462,303 | Feb 29 | 20th Century Fox International | false |
| 5 | The Other Boleyn Girl | - | - | - | $5,162,699 | 217 | $5,865,854 | Feb 29 | Universal Pictures International (UPI) | false |
| 6 | The Spiderwick Chronicles | - | - | - | $4,338,677 | 291 | $5,532,022 | Mar 14 | Universal Pictures International (UPI) | false |
| 7 | No Country for Old Men | - | - | - | $3,771,085 | 308 | $10,785,397 | Feb 8 | Universal Pictures International (UPI) | false |
| 8 | Jumper | - | - | - | $3,036,151 | 447 | $10,448,873 | Feb 15 | 20th Century Fox International | false |
| 9 | Meet the Spartans | - | - | - | $2,966,369 | 316 | $6,542,138 | Mar 28 | 20th Century Fox International | false |
| 10 | Juno | - | - | - | $2,890,967 | 200 | $8,237,494 | Feb 1 | 20th Century Fox International | false |
| 11 | The Water Horse | - | - | - | $2,878,951 | 205 | $3,438,882 | Mar 7 | Sony Pictures Releasing | false |
| 12 | The Eye | - | - | - | $2,543,606 | 218 | $2,864,484 | Mar 14 | DeAPlaneta | false |
| 13 | The Counterfeiters | - | - | - | $2,260,628 | 119 | $3,871,085 | Mar 14 | Wanda Visión S.A. | false |
| 14 | Charlie Wilson's War | - | - | - | $2,132,741 | 256 | $4,433,377 | Feb 22 | Universal Pictures International (UPI) | false |
| 15 | Asterix at the Olympic Games | - | - | - | $2,088,416 | 385 | $9,181,000 | Feb 8 | TriPictures | false |
| 16 | Dan in Real Life | - | - | - | $1,688,735 | 191 | $2,706,563 | Mar 19 | Universal Pictures International (UPI) | false |
| 17 | Sweeney Todd: The Demon Barber of Fleet Street | - | - | - | $1,434,207 | 274 | $5,144,278 | Feb 15 | Warner Bros. | false |
| 18 | The Game Plan | - | - | - | $1,408,414 | 250 | $6,016,924 | Mar 28 | Walt Disney Pictures | false |
| 19 | We Own the Night | - | - | - | $1,375,357 | 224 | $3,742,720 | Mar 28 | Universal Pictures International (UPI) | false |
| 20 | One Missed Call | - | - | - | $1,358,778 | 165 | $2,119,000 | Mar 19 | Warner Bros. | false |
| 21 | The Kite Runner | - | - | - | $1,292,668 | 135 | $1,870,588 | Mar 7 | Universal Pictures International (UPI) | false |
| 22 | Silk | - | - | - | $1,246,507 | 160 | $2,029,874 | Mar 19 | TriPictures | false |
| 23 | The Orphanage | - | - | - | $1,001,069 | 373 | $37,725,830 | Oct 11 | Warner Bros. | false |
| 24 | There Will Be Blood | - | - | - | $966,717 | 104 | $2,415,805 | Feb 15 | Walt Disney Pictures | false |
| 25 | Rise: Blood Hunter | - | - | - | $791,710 | 150 | $823,623 | Feb 29 | Aurum Films | false |
| 26 | The Bucket List | - | - | - | $722,889 | 270 | $5,682,938 | Feb 1 | Warner Bros. | false |
| 27 | The Oxford Murders | - | - | - | $708,626 | 271 | $12,525,441 | Jan 18 | Warner Bros. | false |
| 28 | Mortadelo and Filemon: Mission - Save the Planet | - | - | - | $683,965 | 492 | $11,945,068 | Jan 25 | On Pictures | false |
| 29 | Awake | - | - | - | $616,766 | 206 | $1,513,431 | Mar 28 | Aurum Films | false |
| 30 | The Edge of Heaven | - | - | - | $599,250 | 33 | $1,340,082 | Mar 14 | Golem Distribución | false |
| 31 | I Am Legend | - | - | - | $510,131 | 442 | $19,274,927 | Dec 19 | Warner Bros. | false |
| 32 | The Golden Compass | - | - | - | $508,521 | 505 | $19,180,460 | Dec 5 | TriPictures | false |
| 33 | American Gangster | - | - | - | $415,639 | 440 | $14,529,675 | Dec 28 | Universal Pictures International (UPI) | false |
| 34 | Franklin and the Turtle Lake Treasure | - | - | - | $382,221 | 106 | $766,086 | Feb 22 | Wanda Visión S.A. | false |
| 35 | National Treasure: Book of Secrets | - | - | - | $377,131 | 433 | $14,121,148 | Dec 21 | Walt Disney Pictures | false |
| 36 | Buddha Collapsed Out of Shame | - | - | - | $366,125 | 19 | $489,438 | Feb 29 | Wanda Visión S.A. | false |
| 37 | El último justo | - | - | - | $346,477 | 126 | $368,925 | Feb 29 | Filmax | false |
| 38 | Enchanted | - | - | - | $327,877 | 353 | $12,232,703 | Nov 23 | Walt Disney Pictures | false |
| 39 | REC | - | - | - | $327,431 | 275 | $12,343,196 | Nov 23 | Filmax | false |
| 40 | Alvin and the Chipmunks | - | - | - | $317,996 | 342 | $9,185,192 | Dec 21 | 20th Century Fox International | false |
| 41 | Lo mejor de mí | - | - | - | $306,390 | 30 | $401,227 | Mar 7 | Alta Films | false |
| 42 | Atonement | - | - | - | $302,305 | 192 | $6,137,012 | Jan 11 | Universal Pictures International (UPI) | false |
| 43 | Bee Movie | - | - | - | $299,327 | 428 | $11,133,015 | Nov 30 | Universal Pictures International (UPI) | false |
| 44 | Sleeping Dogs Lie | - | - | - | $275,112 | 23 | $342,196 | Mar 7 | Laurenfilm | false |
| 45 | It's a Free World... | - | - | - | $273,275 | 85 | $565,458 | Feb 22 | Alta Films | false |
| 46 | Caramel | - | - | - | $264,843 | 60 | $1,848,875 | Jan 18 | Alta Films | false |
| 47 | 30 Days of Night | - | - | - | $239,599 | 300 | $4,113,870 | Feb 8 | Sony Pictures Releasing | false |
| 48 | P2 | - | - | - | $228,081 | 133 | $705,835 | Feb 22 | DeAPlaneta | false |
| 49 | 4 Months, 3 Weeks and 2 Days | - | - | - | $215,106 | 36 | $1,063,172 | Jan 25 | Golem Distribución | false |
| 50 | I Want Candy | - | - | - | $214,061 | 56 | $226,842 | Mar 14 | Flins & Piniculas | false |
| 51 | In the Valley of Elah | - | - | - | $213,162 | 125 | $3,046,512 | Jan 18 | Aurum Films | false |
| 52 | Closing the Ring | - | - | - | $212,439 | 24 | $269,893 | Mar 14 | Manga Entertainment | false |
| 53 | Beowulf | - | - | - | $198,917 | 451 | $7,169,936 | Nov 23 | Warner Bros. | false |
| 54 | Love in the Time of Cholera | - | - | - | $196,351 | 262 | $4,202,408 | Jan 18 | Aurum Films | false |
| 55 | Las 13 rosas | - | - | - | $194,212 | 233 | $6,881,072 | Oct 19 | Alta Films | false |
| 56 | Rambo | - | - | - | $180,335 | 348 | $5,323,543 | Feb 1 | Manga Entertainment | false |
| 57 | La soledad | - | - | - | $168,887 | 40 | $1,020,921 | Jun 1 | Wanda Visión S.A. | false |
| 58 | El menor de los males | - | - | - | $161,656 | 56 | $173,694 | Mar 14 | Filmax | false |
| 59 | The Killing Gene | - | - | - | $143,336 | 75 | $150,906 | Feb 29 | Vértigo Films | false |
| 60 | Private Fears in Public Places | - | - | - | $142,315 | 18 | $288,742 | Feb 15 | Baditri | false |
| 61 | KM 31: Kilometre 31 | - | - | - | $125,878 | 96 | $597,338 | Feb 15 | Filmax | false |
| 62 | Cloverfield | - | - | - | $118,046 | 363 | $3,833,132 | Feb 1 | Universal Pictures International (UPI) | false |
| 63 | Michael Clayton | - | - | - | $113,396 | 264 | $4,139,644 | Nov 16 | DeAPlaneta | false |
| 64 | Bab'Aziz: The Prince That Contemplated His Soul | - | - | - | $100,418 | 6 | $257,291 | Mar 7 | Karma Films | false |
| 65 | Seraphim Falls | - | - | - | $95,598 | 52 | $100,168 | Mar 7 | Aurum Films | false |
| 66 | The Call of Wild | - | - | - | $90,663 | 52 | $96,220 | Mar 7 | Notro Films | false |
| 67 | Into the Wild | - | - | - | $66,414 | 81 | $780,998 | Jan 25 | Universal Pictures International (UPI) | false |
| 68 | Once | - | - | - | $63,293 | 27 | $879,999 | Oct 31 | Avalon | false |
| 69 | Irina Palm | - | - | - | $63,236 | 32 | $807,806 | Dec 14 | Golem Distribución | false |
| 70 | Noah's Ark | - | - | - | $62,524 | 227 | $2,448,956 | Dec 21 | Sony Pictures Releasing | false |
| 71 | Lust, Caution | - | - | - | $61,107 | 126 | $2,247,011 | Dec 14 | Universal Pictures International (UPI) | false |
| 72 | Myway | - | - | - | $59,997 | 46 | $156,591 | Feb 1 | Baditri | false |
| 73 | The Lark Farm | - | - | - | $55,800 | 50 | $373,080 | Dec 28 | Sagrera TV | false |
| 74 | Martian Child | - | - | - | $54,381 | 138 | $282,607 | Feb 22 | TriPictures | false |
| 75 | The Silence Before Bach | - | - | - | $47,985 | 5 | $322,116 | Dec 21 | Sherlock Films | false |
| 76 | The Diving Bell and the Butterfly | - | - | - | $42,817 | 57 | $356,647 | Feb 1 | Vértigo Films | false |
| 77 | The Last Mimzy | - | - | - | $35,146 | 156 | $985,263 | Jan 4 | TriPictures | false |
| 78 | This Is England | - | - | - | $31,878 | 40 | $739,369 | Jan 4 | Festival Films S.L. | false |
| 79 | WWW: What a Wonderful World | - | - | - | $26,421 | 3 | $26,421 | Feb 29 | Sherlock Films | false |
| 80 | Underdog | - | - | - | $26,108 | 50 | $248,616 | Feb 1 | Walt Disney Pictures | false |
| 81 | Silent Light | - | - | - | $25,999 | 6 | $49,389 | Feb 22 | Golem Distribución | false |
| 82 | Manufactured Landscapes | - | - | - | $23,876 | 13 | $23,876 | Mar 7 | Karma Films | false |
| 83 | Oscar: The Color of Destiny | - | - | - | $22,170 | 61 | $108,311 | Feb 22 | Aurum Films | false |
| 84 | Away from Her | - | - | - | $16,898 | 43 | $565,387 | Dec 21 | Notro Films | false |
| 85 | Dreams | - | - | - | $16,101 | 2 | $24,972 | Mar 19 | Sagrera TV | false |
| 86 | Love Sick 2008 Re-release | - | - | - | $16,094 | 11 | $36,446 | Mar 28 | Baditri | false |
| 87 | The Jane Austen Book Club | - | - | - | $15,995 | 30 | $120,029 | Feb 8 | Sony Pictures Releasing | false |
| 88 | Blade Runner The Final Cut (2007 re-release) | - | - | - | $12,322 | 12 | $426,713 | Nov 16 | Warner Bros. | false |
| 89 | Have Mercy on Us All | - | - | - | $11,848 | 28 | $45,571 | Feb 15 | Laurenfilm | false |
| 90 | Our Daily Bread | - | - | - | $11,651 | 13 | $11,651 | Mar 14 | Karmic Release Ltd. | false |
| 91 | XXY | - | - | - | $11,435 | 34 | $335,975 | Jan 11 | Wanda Visión S.A. | false |
| 92 | Talk to Me | - | - | - | $10,733 | 4 | $10,733 | Mar 14 | Versus Entertainment | false |
| 93 | Black Gold | - | - | - | $10,172 | 11 | $25,561 | Mar 28 | Karma Films | false |
| 94 | Love and Honor | - | - | - | $10,059 | 4 | $37,174 | Mar 28 | Notro Films | false |
| 95 | Pingpong | - | - | - | $9,159 | 3 | $22,407 | Mar 28 | Sherlock Films | false |
| 96 | Back to Normandy | - | - | - | $7,900 | 8 | $14,138 | Mar 28 | Karma Films | false |
| 97 | The Missing Star | - | - | - | $7,596 | 5 | $67,299 | Jan 11 | Filmax | false |
| 98 | Hula Girls | - | - | - | $4,531 | 14 | $42,550 | Jan 25 | - | false |
| 99 | Siete mesas de billar francés | - | - | - | $3,708 | 120 | $1,693,814 | Oct 5 | Universal Pictures International (UPI) | false |
| 100 | Japón 2008 Re-release | - | - | - | $3,114 | 4 | $10,082 | Mar 7 | Golem Distribución | false |
| 101 | Death at a Funeral | - | - | - | $2,315 | 128 | $3,949,527 | Oct 11 | DeAPlaneta | false |
| 102 | Across the Universe | - | - | - | $1,977 | 30 | $135,227 | Jan 4 | Sony Pictures Releasing | false |
| 103 | Mr. Magorium's Wonder Emporium | - | - | - | $1,815 | 296 | $2,371,539 | Dec 14 | DeAPlaneta | false |
| 104 | Sunday Light | - | - | - | $1,809 | 115 | $1,032,535 | Nov 16 | Sony Pictures Releasing | false |
| 105 | La zona de Tarkovsky | - | - | - | $1,627 | 1 | $1,627 | Mar 14 | Independent Films | false |
| 106 | Prince and Me and You | - | - | - | $885 | 202 | $1,016,516 | Dec 21 | DeAPlaneta | false |
| 107 | Relative Strangers | - | - | - | $789 | 6 | $17,015 | Jan 25 | Filmax | false |
| 108 | El prado de las estrellas | - | - | - | $712 | 25 | $189,244 | Jan 11 | Manga Entertainment | false |
| 109 | El pollo, el pez y el cangrejo real | - | - | - | $580 | 4 | $9,041 | Feb 15 | Wanda Visión S.A. | false |
| 110 | Clandestinos | - | - | - | $133 | 10 | $18,575 | Feb 15 | Eurocine | false |
| 111 | Blindsight | - | - | - | $90 | 1 | $11,984 | Mar 19 | Karma Films | false |
| 112 | Los perdedores | - | - | - | $55 | 1 | $55 | Mar 14 | Independent Films | false |
