| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Ho voglia di te | - | - | - | $17,876,885 | 575 | $18,594,142 | Mar 9 | Warner Bros. | false |
| 2 | 300 | - | - | - | $9,443,296 | 470 | $14,618,081 | Mar 23 | Warner Bros. | false |
| 3 | Borat | - | - | - | $7,615,130 | 407 | $8,364,555 | Mar 2 | 20th Century Fox International | false |
| 4 | Il 7 e l'8 | - | - | - | $7,016,724 | 306 | $10,412,376 | Mar 16 | Medusa Distribuzione | false |
| 5 | Saturn in Opposition | - | - | - | $5,653,209 | 399 | $10,652,524 | Feb 23 | Medusa Distribuzione | false |
| 6 | Saw III | - | - | - | $4,819,936 | 305 | $4,895,245 | Mar 9 | 20th Century Fox International | false |
| 7 | Ghost Rider | - | - | - | $3,717,075 | 302 | $4,024,178 | Mar 16 | Sony Pictures Releasing | false |
| 8 | Norbit | - | - | - | $3,187,523 | 266 | $4,256,342 | Mar 23 | Universal Pictures International (UPI) | false |
| 9 | Music and Lyrics | - | - | - | $2,716,225 | 326 | $5,080,907 | Feb 23 | Warner Bros. | false |
| 10 | Notte prima degli esami - Oggi | - | - | - | $2,679,997 | 604 | $16,544,856 | Feb 14 | 01 Distribution | false |
| 11 | Flying Lessons | - | - | - | $1,718,578 | 147 | $2,270,431 | Mar 16 | 01 Distribution | false |
| 12 | One Out of Two | - | - | - | $1,517,342 | 176 | $1,698,848 | Mar 2 | 01 Distribution | false |
| 13 | Bordertown | - | - | - | $1,381,873 | 195 | $1,907,846 | Mar 23 | Medusa Distribuzione | false |
| 14 | Bridge to Terabithia | - | - | - | $1,374,646 | 315 | $3,249,576 | Mar 30 | Moviemax | false |
| 15 | Because I Said So | - | - | - | $1,350,674 | 219 | $1,682,577 | Mar 23 | Eagle Pictures | false |
| 16 | Night at the Museum | - | - | - | $1,251,041 | 471 | $16,188,874 | Feb 2 | 20th Century Fox International | false |
| 17 | Alpha Dog | - | - | - | $1,199,959 | 190 | $2,378,866 | Feb 23 | Moviemax | false |
| 18 | Notes on a Scandal | - | - | - | $1,085,122 | 94 | $1,983,521 | Feb 23 | 20th Century Fox International | false |
| 19 | Asterix and the Vikings | - | - | - | $794,579 | 201 | $960,624 | Mar 16 | DNC Entertainment | false |
| 20 | Stay Alive | - | - | - | $700,827 | 162 | $1,411,248 | Mar 30 | Medusa Distribuzione | false |
| 21 | The Good German | - | - | - | $681,951 | 80 | $820,492 | Mar 2 | Warner Bros. | false |
| 22 | One Hundred Nails | - | - | - | $541,588 | 157 | $3,404,025 | Mar 30 | Mikado Film | false |
| 23 | The Lark Farm | - | - | - | $540,357 | 68 | $1,033,304 | Mar 23 | 01 Distribution | false |
| 24 | In Memory of Me | - | - | - | $501,750 | 88 | $722,672 | Mar 9 | Medusa Distribuzione | false |
| 25 | The Holiday | - | - | - | $451,403 | 319 | $6,079,376 | Feb 9 | Universal Pictures International (UPI) | false |
| 26 | Barnyard | - | - | - | $438,744 | 150 | $1,119,394 | Feb 23 | Universal Pictures International (UPI) | false |
| 27 | Hannibal Rising | - | - | - | $438,411 | 365 | $7,566,213 | Feb 9 | Filmauro | false |
| 28 | The Departed | - | - | - | $393,229 | 422 | $12,237,244 | Oct 27 | Medusa Distribuzione | false |
| 29 | The Last King of Scotland | - | - | - | $336,171 | 87 | $862,325 | Feb 16 | 20th Century Fox International | false |
| 30 | Maradona, the Hand of God | - | - | - | $303,226 | 115 | $642,321 | Mar 30 | 01 Distribution | false |
| 31 | El ratón Pérez | - | - | - | $248,178 | 92 | $358,417 | Mar 23 | Mediafilm | false |
| 32 | The Painted Veil | - | - | - | $237,675 | 65 | $610,692 | Feb 23 | Eagle Pictures | false |
| 33 | Goodbye Bafana | - | - | - | $228,666 | 105 | $546,873 | Mar 30 | Istituto Luce | false |
| 34 | Still Life | - | - | - | $214,850 | 23 | $391,607 | Mar 23 | Lucky Red | false |
| 35 | Letters from Iwo Jima | - | - | - | $206,167 | 55 | $987,775 | Feb 16 | Warner Bros. | false |
| 36 | Private Property | - | - | - | $142,987 | 23 | $211,931 | Mar 16 | BIM Distribuzione | false |
| 37 | Death of a President | - | - | - | $94,413 | 68 | $164,858 | Mar 16 | Lucky Red | false |
| 38 | The Fountain | - | - | - | $72,685 | 39 | $119,205 | Mar 16 | 20th Century Fox International | false |
| 39 | Blood Diamond | - | - | - | $49,188 | 266 | $5,701,333 | Jan 26 | Warner Bros. | false |
| 40 | A Dinner for Them to Meet | - | - | - | $47,358 | 262 | $4,173,202 | Feb 2 | Medusa Distribuzione | false |
| 41 | The Pursuit of Happyness | - | - | - | $42,515 | 441 | $21,309,984 | Jan 12 | Medusa Distribuzione | false |
