| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | F9: The Fast Saga | - | - | - | $88,163,505 | 4,203 | $173,005,945 | Jun 25 | Universal Pictures | false |
| 2 | A Quiet Place Part II | - | - | - | $82,180,220 | 3,744 | $160,072,261 | May 28 | Paramount Pictures | false |
| 3 | The Conjuring: The Devil Made Me Do It | - | - | - | $57,113,366 | 3,280 | $65,631,050 | Jun 4 | Warner Bros. | false |
| 4 | Cruella | - | - | - | $46,881,023 | 3,922 | $86,103,234 | May 28 | Walt Disney Studios Motion Pictures | false |
| 5 | Peter Rabbit 2: The Runaway | - | - | - | $31,422,722 | 3,346 | $40,501,717 | Jun 11 | Sony Pictures Releasing | false |
| 6 | Hitman's Wife's Bodyguard | - | - | - | $27,769,227 | 3,361 | $38,014,727 | Jun 16 | Lionsgate | false |
| 7 | In the Heights | - | - | - | $22,581,509 | 3,509 | $29,975,167 | Jun 11 | Warner Bros. | false |
| 8 | Spirit Untamed | - | - | - | $16,406,150 | 3,394 | $17,716,215 | Jun 4 | Universal Pictures | false |
| 9 | Wrath of Man | - | - | - | $4,589,008 | 3,007 | $27,466,489 | May 7 | United Artists Releasing | false |
| 10 | Spiral | - | - | - | $2,963,938 | 2,991 | $23,216,862 | May 14 | Lionsgate | false |
| 11 | Raya and the Last Dragon | - | - | - | $2,782,634 | 2,375 | $54,723,032 | Mar 5 | Walt Disney Studios Motion Pictures | false |
| 12 | The House Next Door: Meet the Blacks 2 | - | - | - | $2,629,430 | 539 | $2,893,660 | Jun 11 | Hidden Empire Film Group (HEFG) | false |
| 13 | 12 Mighty Orphans | - | - | - | $2,459,162 | 1,047 | $3,689,637 | Jun 11 | Sony Pictures Releasing | false |
| 14 | Godzilla vs. Kong | - | - | - | $2,441,277 | 3,084 | $100,916,094 | Mar 31 | Warner Bros. | false |
| 15 | Demon Slayer: Kimetsu no Yaiba - The Movie: Mugen Train | - | - | - | $2,356,443 | 2,087 | $49,505,008 | Apr 23 | FUNimation Entertainment | false |
| 16 | Queen Bees | - | - | - | $1,406,439 | 600 | $1,926,706 | Jun 11 | Gravitas Ventures | false |
| 17 | Nobody | - | - | - | $879,395 | 2,567 | $27,568,035 | Mar 26 | Universal Pictures | false |
| 18 | Dream Horse | - | - | - | $869,510 | 1,284 | $2,913,328 | May 21 | Bleecker Street Media | false |
| 19 | Those Who Wish Me Dead | - | - | - | $637,541 | 3,379 | $7,407,200 | May 14 | Warner Bros. | false |
| 20 | Witnesses | - | - | - | $630,018 | 90 | $855,765 | Jun 4 | Purdie Distribution | false |
| 21 | The Sparks Brothers | - | - | - | $575,090 | 534 | $648,665 | Jun 18 | Focus Features | false |
| 22 | Zola | - | - | - | $504,992 | 1,468 | $4,844,399 | Jun 30 | A24 | false |
| 23 | Mortal Kombat | - | - | - | $414,257 | 3,114 | $42,326,031 | Apr 23 | Warner Bros. | false |
| 24 | Werewolves Within | - | - | - | $331,914 | 270 | $575,783 | Jun 25 | IFC Films | false |
| 25 | The Croods: A New Age | - | - | - | $259,910 | 2,211 | $58,568,815 | Nov 25 | Universal Pictures | false |
| 26 | Finding You | - | - | - | $257,248 | 1,447 | $2,753,985 | May 14 | Roadside Attractions | false |
| 27 | Tom & Jerry | - | - | - | $216,485 | 2,563 | $46,536,687 | Feb 26 | Warner Bros. | false |
| 28 | Rita Moreno: Just a Girl Who Decided to Go for It | - | - | - | $209,223 | 227 | $264,626 | Jun 18 | Roadside Attractions | false |
| 29 | Here Today | - | - | - | $111,009 | 1,230 | $2,807,494 | May 7 | Stage 6 Films | false |
| 30 | The Truffle Hunters | - | - | - | $104,624 | 105 | $521,202 | Mar 5 | Sony Pictures Classics | false |
| 31 | The Dry | - | - | - | $98,289 | 186 | $364,237 | May 21 | IFC Films | false |
| 32 | The Unholy | - | - | - | $89,763 | 2,057 | $15,532,137 | Apr 2 | Screen Gems | false |
| 33 | Children of the Sea | - | - | - | $81,237 | 633 | $81,237 | Mar 20 | Fathom Events | false |
| 34 | Undine | - | - | - | $69,473 | 56 | $78,689 | Jun 4 | IFC Films | false |
| 35 | Censor | - | - | - | $61,227 | 93 | $90,050 | Jun 11 | Magnolia Pictures | false |
| 36 | DOMINO: Battle of the Bones | - | - | - | $50,124 | - | $50,124 | Jun 11 | TriCoast Worldwide | false |
| 37 | The Swimming Pool 2021 Re-release | - | - | - | $45,932 | 10 | $211,467 | May 14 | Rialto Distribution | false |
| 38 | The Courier | - | - | - | $37,384 | 1,641 | $6,613,432 | Mar 19 | Roadside Attractions | false |
| 39 | Summer of 85 | - | - | - | $37,362 | 23 | $71,788 | Jun 18 | Music Box Films | false |
| 40 | All Light, Everywhere | - | - | - | $37,266 | 19 | $37,266 | Jun 4 | Super LTD | false |
| 41 | Lansky | - | - | - | $36,930 | 49 | $61,030 | Jun 25 | Vertical Entertainment | false |
| 42 | Truman & Tennessee: An Intimate Conversation | - | - | - | $30,511 | 22 | $54,817 | Jun 18 | Kino Lorber | false |
| 43 | New Order | - | - | - | $28,940 | 236 | $303,556 | May 21 | Neon | false |
| 44 | Holler | - | - | - | $27,793 | 31 | $28,706 | Jun 11 | IFC Films | false |
| 45 | Shiva Baby | - | - | - | $27,131 | 27 | $159,294 | Apr 2 | Utopia | false |
| 46 | French Exit | - | - | - | $27,086 | 493 | $741,895 | Feb 12 | Sony Pictures Classics | false |
| 47 | Final Account | - | - | - | $24,981 | 308 | $308,976 | May 21 | Focus Features | false |
| 48 | Our Ladies | - | - | - | $24,360 | 25 | $27,558 | Jun 18 | Sony Pictures Releasing | false |
| 49 | Riders of Justice | - | - | - | $23,740 | 18 | $77,115 | May 14 | Magnolia Pictures | false |
| 50 | Gully | - | - | - | $22,517 | 100 | $22,517 | Jun 4 | Vertical Entertainment | false |
| 51 | Hero Mode | - | - | - | $21,178 | 46 | $21,178 | Jun 4 | Blue Fox Entertainment | false |
| 52 | I Carry You with Me | - | - | - | $20,184 | 111 | $166,403 | Jun 25 | Sony Pictures Classics | false |
| 53 | Gaia | - | - | - | $17,530 | 75 | $17,530 | Jun 18 | Neon | false |
| 54 | Together Together | - | - | - | $17,366 | 665 | $1,437,938 | Apr 23 | Bleecker Street Media | false |
| 55 | The Girl Who Believes in Miracles | - | - | - | $15,897 | 1,012 | $3,163,362 | Apr 2 | Atlas Distribution Company | false |
| 56 | The Father | - | - | - | $15,280 | 933 | $2,122,771 | Feb 26 | Sony Pictures Classics | false |
| 57 | The Red Circle 2021 Re-release | - | - | - | $14,772 | 5 | $62,850 | Jun 25 | Rialto Pictures | false |
| 58 | The Perfect Candidate | - | - | - | $14,760 | 17 | $30,134 | May 14 | Music Box Films | false |
| 59 | The Ladykillers 2021 Re-release | - | - | - | $12,772 | 3 | $23,213 | Jun 4 | Rialto Pictures | false |
| 60 | The Paper Tigers | - | - | - | $11,881 | 65 | $112,691 | May 7 | Well Go USA Entertainment | false |
| 61 | A Soldier's Story 2: Return from the Dead | - | - | - | $11,190 | 5 | $21,543 | Jun 26 | Indican Pictures | false |
| 62 | The Water Man | - | - | - | $9,848 | 311 | $383,234 | May 7 | RLJE Films | false |
| 63 | Profile | - | - | - | $9,650 | 2,104 | $1,744,740 | May 14 | Focus Features | false |
| 64 | The War with Grandpa | - | - | - | $8,766 | 2,365 | $21,277,892 | Oct 9 | 101 Studios | false |
| 65 | Separation | - | - | - | $8,073 | 1,911 | $4,509,143 | Apr 30 | Open Road Films (II) | false |
| 66 | About Endlessness | - | - | - | $7,600 | 17 | $51,386 | Apr 30 | Magnolia Pictures | false |
| 67 | Final Frequency | - | - | - | $7,098 | 9 | $7,098 | Jun 11 | Integrity Releasing | false |
| 68 | The Killing of Two Lovers | - | - | - | $5,094 | 36 | $71,162 | May 14 | Neon | false |
| 69 | Sweat | - | - | - | $3,406 | 6 | $11,546 | Jun 18 | MUBI | false |
| 70 | Mission Stories | - | - | - | $3,393 | 44 | $87,059 | May 7 | Excel Entertainment | false |
| 71 | The Djinn | - | - | - | $2,720 | 44 | $124,772 | May 14 | IFC Films | false |
| 72 | Cliff Walkers | - | - | - | $2,646 | 65 | $152,972 | Apr 30 | CMC Pictures | false |
| 73 | Crack House of the Dead | - | - | - | $1,616 | 5 | $1,616 | Jun 18 | Sunrayz International Films | false |
| 74 | My Love | - | - | - | $1,065 | 25 | $86,252 | May 7 | CMC Pictures | false |
| 75 | 100% Wolf | - | - | - | $1,017 | 124 | $658,764 | Oct 9 | Viva Pictures | false |
| 76 | Mainstream | - | - | - | $1,017 | 76 | $35,696 | May 7 | IFC Films | false |
| 77 | The Evil Next Door | - | - | - | $462 | 3 | $1,010 | Jun 25 | Magnolia Pictures | false |
| 78 | The Incredible 25th Year of Mitzi Bearclaw | - | - | - | $258 | 2 | $10,368 | Feb 12 | Indican Pictures | false |
| 79 | Funhouse | - | - | - | $216 | 3 | $507 | May 28 | Magnet Releasing | false |
| 80 | Ghost Master | - | - | - | $183 | 2 | $6,136 | May 14 | Indican Pictures | false |
| 81 | First Signal | - | - | - | $130 | 1 | $880 | Mar 26 | The Ashton Times | false |
| 82 | Felix and the Hidden Treasure | - | - | - | $126 | 10 | $153 | Jun 25 | Viva Pictures | false |
| 83 | There Is No Evil | - | - | - | $123 | 7 | $8,063 | May 14 | Kino Lorber | false |
| 84 | The World to Come | - | - | - | $81 | 277 | $116,143 | Feb 12 | Bleecker Street Media | false |
| 85 | Lamb of God: The Concert Film | - | - | - | $10 | 138 | $744,813 | Mar 12 | Excel Entertainment | false |
