| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Toy Story 3 | - | - | - | $251,344,663 | 4,028 | $415,004,880 | Jun 18 | Walt Disney Studios Motion Pictures | false |
| 2 | The Karate Kid | - | - | - | $141,831,367 | 3,740 | $176,591,618 | Jun 11 | Sony Pictures Releasing | false |
| 3 | Shrek Forever After | - | - | - | $84,268,711 | 4,386 | $238,736,787 | May 21 | DreamWorks | false |
| 4 | The Twilight Saga: Eclipse | - | - | - | $68,533,840 | 4,468 | $300,531,751 | Jun 30 | Summit Entertainment | false |
| 5 | The A-Team | - | - | - | $65,459,385 | 3,544 | $77,222,099 | Jun 11 | Twentieth Century Fox | false |
| 6 | Get Him to the Greek | - | - | - | $55,979,245 | 2,702 | $60,974,475 | Jun 4 | Universal Pictures | false |
| 7 | Grown Ups | - | - | - | $54,486,646 | 3,534 | $162,001,186 | Jun 25 | Sony Pictures Releasing | false |
| 8 | Prince of Persia: The Sands of Time | - | - | - | $49,408,473 | 3,646 | $90,759,676 | May 28 | Walt Disney Studios Motion Pictures | false |
| 9 | Killers | - | - | - | $44,616,016 | 2,859 | $47,059,963 | Jun 4 | Lionsgate | false |
| 10 | Sex and the City 2 | - | - | - | $42,541,869 | 3,445 | $95,347,692 | May 27 | Warner Bros. | false |
| 11 | Knight and Day 2010 Re-release | - | - | - | $33,477,337 | 3,104 | $76,423,035 | Jun 23 | Twentieth Century Fox | false |
| 12 | Marmaduke | - | - | - | $30,403,433 | 3,213 | $33,644,788 | Jun 4 | Twentieth Century Fox | false |
| 13 | Iron Man 2 | - | - | - | $27,840,367 | 4,390 | $312,433,331 | May 7 | Paramount Pictures | false |
| 14 | Robin Hood | - | - | - | $17,386,730 | 3,505 | $105,269,730 | May 14 | Universal Pictures | false |
| 15 | Splice 2010 Re-release | - | - | - | $16,353,294 | 2,450 | $17,010,170 | Jun 4 | Warner Bros. | false |
| 16 | The Last Airbender | - | - | - | $15,009,510 | 3,203 | $131,772,187 | Jul 1 | Paramount Pictures | false |
| 17 | Letters to Juliet | - | - | - | $11,771,879 | 2,975 | $53,032,453 | May 14 | Summit Entertainment | false |
| 18 | Jonah Hex | - | - | - | $9,772,467 | 2,825 | $10,547,117 | Jun 18 | Warner Bros. | false |
| 19 | Date Night | - | - | - | $3,410,761 | 3,380 | $98,711,404 | Apr 9 | Twentieth Century Fox | false |
| 20 | How to Train Your Dragon | - | - | - | $2,596,918 | 4,060 | $217,581,231 | Mar 26 | DreamWorks | false |
| 21 | Just Wright | - | - | - | $2,415,693 | 1,831 | $21,540,363 | May 14 | - | false |
| 22 | Twilight/New Moon Double Bill | - | - | - | $2,385,237 | 2,037 | $2,385,237 | Jun 29 | Summit Entertainment | false |
| 23 | Hubble | - | - | - | $2,255,416 | 151 | $52,522,904 | Mar 19 | Warner Bros. | false |
| 24 | The Secret in Their Eyes | - | - | - | $2,087,348 | 166 | $6,391,436 | Apr 16 | Sony Pictures Classics | false |
| 25 | Solitary Man | - | - | - | $1,974,517 | 177 | $4,360,548 | May 21 | Anchor Bay Films | false |
| 26 | The Girl with the Dragon Tattoo | - | - | - | $1,967,659 | 202 | $10,095,170 | Mar 19 | Music Box Films | false |
| 27 | Please Give | - | - | - | $1,893,937 | 272 | $4,033,574 | Apr 30 | Sony Pictures Classics | false |
| 28 | Raajneeti | - | - | - | $1,488,178 | 124 | $1,514,558 | Jun 4 | UTV Motion Pictures | false |
| 29 | Clash of the Titans | - | - | - | $1,394,177 | 3,802 | $163,214,888 | Apr 2 | Warner Bros. | false |
| 30 | City Island | - | - | - | $1,340,016 | 269 | $6,671,036 | Mar 19 | Anchor Bay Films | false |
| 31 | Alice in Wonderland | - | - | - | $1,229,442 | 3,739 | $334,191,110 | Mar 5 | Walt Disney Studios Motion Pictures | false |
| 32 | Winter's Bone | - | - | - | $1,221,903 | 141 | $6,531,503 | Jun 11 | Roadside Attractions | false |
| 33 | The Bounty Hunter | - | - | - | $1,187,760 | 3,118 | $67,061,228 | Mar 19 | Sony Pictures Releasing | false |
| 34 | Babies | - | - | - | $1,136,778 | 543 | $7,320,323 | May 7 | Focus Features | false |
| 35 | Joan Rivers: A Piece of Work | - | - | - | $1,069,753 | 115 | $2,930,687 | Jun 11 | IFC Films | false |
| 36 | A Nightmare on Elm Street | - | - | - | $1,032,959 | 3,332 | $63,075,011 | Apr 30 | Warner Bros. | false |
| 37 | Diary of a Wimpy Kid | - | - | - | $963,479 | 3,083 | $64,003,625 | Mar 19 | Twentieth Century Fox | false |
| 38 | The Last Song | - | - | - | $914,636 | 2,794 | $62,950,384 | Mar 31 | Walt Disney Studios Motion Pictures | false |
| 39 | MacGruber | - | - | - | $851,155 | 2,551 | $8,525,600 | May 21 | Universal Pictures | false |
| 40 | Furry Vengeance | - | - | - | $848,537 | 3,002 | $17,630,465 | Apr 30 | Summit Entertainment | false |
| 41 | Exit Through the Gift Shop | - | - | - | $805,243 | 46 | $3,291,250 | Apr 16 | - | false |
| 42 | Micmacs | - | - | - | $710,649 | 52 | $1,262,079 | May 28 | Sony Pictures Classics | false |
| 43 | The Back-up Plan | - | - | - | $696,642 | 3,280 | $37,490,007 | Apr 23 | CBS Films | false |
| 44 | Raavan | - | - | - | $685,960 | 120 | $708,726 | Jun 18 | Reliance Big Pictures | false |
| 45 | Cyrus | - | - | - | $677,829 | 454 | $7,468,936 | Jun 18 | - | false |
| 46 | Harry Brown | - | - | - | $598,900 | 67 | $1,818,681 | Apr 30 | The Samuel Goldwyn Company | false |
| 47 | Death at a Funeral | - | - | - | $577,647 | 2,459 | $42,739,347 | Apr 16 | Screen Gems | false |
| 48 | Kick-Ass | - | - | - | $556,195 | 3,065 | $48,071,303 | Apr 16 | Lionsgate | false |
| 49 | Mother and Child | - | - | - | $514,474 | 119 | $1,110,509 | May 7 | Sony Pictures Classics | false |
| 50 | I Am Love | - | - | - | $514,131 | 166 | $5,005,465 | Jun 18 | Magnolia Pictures | false |
| 51 | Avatar | - | - | - | $488,512 | 3,461 | $749,766,139 | Dec 18 | Twentieth Century Fox | false |
| 52 | Oceans | - | - | - | $420,297 | 1,232 | $19,422,319 | Apr 22 | Walt Disney Studios Motion Pictures | false |
| 53 | Under the Sea 3D | - | - | - | $393,295 | 108 | $36,262,926 | Feb 13 | Warner Bros. | false |
| 54 | The Losers | - | - | - | $344,163 | 2,936 | $23,591,432 | Apr 23 | Warner Bros. | false |
| 55 | Coco Chanel & Igor Stravinsky | - | - | - | $284,567 | 74 | $1,621,226 | Jun 11 | Sony Pictures Classics | false |
| 56 | Hot Tub Time Machine | - | - | - | $280,452 | 2,771 | $50,287,556 | Mar 26 | Metro-Goldwyn-Mayer (MGM) | false |
| 57 | Ondine | - | - | - | $279,043 | 39 | $550,472 | Jun 4 | Magnolia Pictures | false |
| 58 | Magnificent Desolation: Walking on the Moon | - | - | - | $234,354 | 82 | $34,137,524 | Sep 23 | IMAX | false |
| 59 | The Ghost Writer | - | - | - | $209,910 | 819 | $15,541,549 | Feb 19 | Summit Entertainment | false |
| 60 | Princess Kaiulani | - | - | - | $202,941 | 47 | $883,887 | May 14 | Roadside Attractions | false |
| 61 | Shutter Island | - | - | - | $167,893 | 3,356 | $128,012,934 | Feb 19 | Paramount Pictures | false |
| 62 | Agora | - | - | - | $165,410 | 17 | $619,423 | May 28 | Newmarket Films | false |
| 63 | Holy Rollers | - | - | - | $158,259 | 20 | $303,064 | May 21 | First Independent Pictures | false |
| 64 | La Mission | - | - | - | $149,880 | 47 | $1,062,941 | Apr 9 | Screen Media Films | false |
| 65 | Percy Jackson & the Olympians: The Lightning Thief | - | - | - | $149,759 | 3,396 | $88,768,303 | Feb 12 | Twentieth Century Fox | false |
| 66 | Kites | - | - | - | $145,841 | 207 | $1,643,486 | May 21 | Reliance Big Pictures | false |
| 67 | The City of Your Final Destination | - | - | - | $131,698 | 26 | $493,296 | Apr 16 | Screen Media Films | false |
| 68 | Mid-August Lunch | - | - | - | $131,601 | 23 | $675,299 | Mar 17 | Zeitgeist Films | false |
| 69 | Mademoiselle Chambon | - | - | - | $130,842 | 16 | $531,685 | May 28 | Lorber Films | false |
| 70 | Breathless 2010 Re-release | - | - | - | $129,805 | 12 | $363,031 | May 28 | Rialto Pictures | false |
| 71 | Metropolis 2010 Re-release | - | - | - | $121,632 | 9 | $529,603 | May 7 | Kino International | false |
| 72 | Why Did I Get Married Too? | - | - | - | $113,223 | 2,155 | $60,095,852 | Apr 2 | Lionsgate | false |
| 73 | The Secret of Kells | - | - | - | $102,123 | 37 | $676,775 | Mar 5 | GKIDS | false |
| 74 | Father of My Children | - | - | - | $99,500 | 7 | $144,022 | May 21 | IFC Films | false |
| 75 | The Square 2010 Re-release | - | - | - | $96,594 | 24 | $406,116 | Apr 9 | Apparition | false |
| 76 | Deep Sea | - | - | - | $93,381 | 47 | $46,412,757 | Mar 3 | Warner Bros. | false |
| 77 | 8: The Mormon Proposition | - | - | - | $83,277 | 16 | $100,280 | Jun 18 | - | false |
| 78 | Only the Brave | - | - | - | $75,446 | 5 | $150,000 | May 28 | Indican Pictures | false |
| 79 | Kings of the Evening | - | - | - | $74,359 | 5 | $99,270 | Jun 11 | Indican Pictures | false |
| 80 | Stonewall Uprising | - | - | - | $58,183 | 10 | $128,203 | Jun 16 | First Run | false |
| 81 | Chloe | - | - | - | $57,731 | 350 | $3,075,255 | Mar 26 | Sony Pictures Classics | false |
| 82 | Wild Grass | - | - | - | $57,150 | 23 | $403,952 | Jun 25 | Sony Pictures Classics | false |
| 83 | Tooth Fairy | - | - | - | $56,607 | 3,345 | $60,022,256 | Jan 22 | Twentieth Century Fox | false |
| 84 | Survival of the Dead | - | - | - | $54,322 | 20 | $101,740 | May 28 | Magnolia Pictures | false |
| 85 | Restrepo | - | - | - | $51,960 | 52 | $1,330,894 | Jun 25 | National Geographic Entertainment | false |
| 86 | The Human Centipede (First Sequence) | - | - | - | $48,210 | 19 | $181,467 | Apr 30 | IFC Films | false |
| 87 | Let it Rain | - | - | - | $46,366 | 6 | $111,844 | Jun 18 | IFC Films | false |
| 88 | The Killer Inside Me | - | - | - | $45,940 | 17 | $217,277 | Jun 18 | IFC Films | false |
| 89 | Casino Jack and the United States of Money | - | - | - | $43,866 | 21 | $176,865 | May 7 | Magnolia Pictures | false |
| 90 | Sea Monsters: A Prehistoric Adventure | - | - | - | $38,112 | 252 | $23,746,066 | Oct 5 | National Geographic Entertainment | false |
| 91 | Our Family Wedding | - | - | - | $37,436 | 1,609 | $20,255,281 | Mar 12 | - | false |
| 92 | I Hate Luv Storys | - | - | - | $36,770 | 85 | $847,993 | Jun 30 | UTV Motion Pictures | false |
| 93 | The Lottery | - | - | - | $36,557 | 3 | $54,543 | Jun 11 | Variance Films | false |
| 94 | Rosencrantz and Guildenstern Are Undead | - | - | - | $36,111 | 4 | $71,007 | Jun 4 | Indican Pictures | false |
| 95 | The Cremaster Cycle 2010 Re-release | - | - | - | $32,873 | 2 | $151,239 | Apr 9 | International Film Circuit | false |
| 96 | John Rabe | - | - | - | $32,743 | 6 | $67,519 | May 21 | Strand Releasing | false |
| 97 | Living in Emergency | - | - | - | $32,208 | 7 | $32,208 | Jun 4 | Truly Indie | false |
| 98 | The Joneses | - | - | - | $30,765 | 217 | $1,475,746 | Apr 16 | Roadside Attractions | false |
| 99 | The Good the Bad the Weird | - | - | - | $29,625 | 15 | $128,486 | Apr 23 | IFC Films | false |
| 100 | OSS 117: Lost in Rio | - | - | - | $29,327 | 7 | $89,375 | May 7 | Music Box Films | false |
| 101 | Vincere | - | - | - | $28,988 | 36 | $619,162 | Mar 19 | IFC Films | false |
| 102 | Mother | - | - | - | $28,346 | 38 | $551,509 | Mar 12 | Magnolia Pictures | false |
| 103 | Sweetgrass | - | - | - | $27,484 | 9 | $207,473 | Jan 6 | The Cinema Guild | false |
| 104 | Cropsey | - | - | - | $25,958 | 4 | $52,476 | Jun 4 | Cinema Purgatorio | false |
| 105 | South of the Border | - | - | - | $25,656 | 12 | $198,600 | Jun 25 | Cinema Libre Studio | false |
| 106 | A Prophet | - | - | - | $25,197 | 83 | $2,087,720 | Feb 26 | Sony Pictures Classics | false |
| 107 | Looking for Eric | - | - | - | $24,157 | 11 | $55,804 | May 14 | IFC Films | false |
| 108 | Le Amiche | - | - | - | $23,562 | 1 | $68,167 | Jun 18 | The Film Desk | false |
| 109 | Ajami | - | - | - | $21,965 | 23 | $622,403 | Feb 3 | Kino International | false |
| 110 | Touching Home | - | - | - | $20,732 | 7 | $116,353 | Apr 30 | CFI Releasing | false |
| 111 | Best Worst Movie | - | - | - | $19,267 | 2 | $109,895 | Apr 23 | Abramorama | false |
| 112 | Racing Dreams | - | - | - | $17,251 | 33 | $65,082 | May 21 | Hannover House | false |
| 113 | Ran 2010 Re-release | - | - | - | $16,946 | 4 | $124,673 | Feb 5 | Rialto Pictures | false |
| 114 | Double Take | - | - | - | $16,737 | 1 | $20,218 | Jun 2 | Kino International | false |
| 115 | Breakdance Academy | - | - | - | $15,628 | 2 | $15,628 | Jun 4 | - | false |
| 116 | The Eclipse | - | - | - | $15,465 | 12 | $133,411 | Mar 26 | Magnolia Pictures | false |
| 117 | The Sun Behind the Clouds: Tibet's Struggle for Freedom | - | - | - | $13,688 | 4 | $67,095 | Mar 31 | Balcony Releasing | false |
| 118 | No One Knows About Persian Cats | - | - | - | $13,091 | 12 | $81,768 | Apr 16 | IFC Films | false |
| 119 | The Oath | - | - | - | $13,042 | 4 | $42,273 | May 7 | Zeitgeist Films | false |
| 120 | Everyone Else | - | - | - | $12,930 | 5 | $102,042 | Apr 9 | The Cinema Guild | false |
| 121 | Love Ranch | - | - | - | $12,360 | 11 | $137,885 | Jun 30 | - | false |
| 122 | Dogtooth | - | - | - | $10,896 | 5 | $110,248 | Jun 25 | Kino International | false |
| 123 | The Last Station | - | - | - | $10,851 | 354 | $6,617,867 | Jan 15 | Sony Pictures Classics | false |
| 124 | Kites The Remix | - | - | - | $10,592 | 40 | $41,783 | May 28 | Reliance Big Pictures | false |
| 125 | Letters to God | - | - | - | $9,596 | 897 | $2,848,578 | Apr 9 | Vivendi Entertainment | false |
| 126 | Space Station 3D | - | - | - | $9,233 | 64 | $93,383,953 | Apr 19 | IMAX | false |
| 127 | 180° South | - | - | - | $8,745 | 4 | $31,745 | May 21 | Magnolia Pictures | false |
| 128 | 2012: Time for Change | - | - | - | $8,382 | 2 | $68,339 | Apr 9 | Mangusta Productions | false |
| 129 | The Most Dangerous Man in America: Daniel Ellsberg and the Pentagon Papers | - | - | - | $7,770 | 12 | $453,993 | Jan 29 | First Run | false |
| 130 | Two in the Wave | - | - | - | $7,686 | 1 | $28,808 | May 19 | Lorber Films | false |
| 131 | Here and There | - | - | - | $7,448 | 5 | $27,156 | May 14 | Cinema Purgatorio | false |
| 132 | House | - | - | - | $7,304 | 7 | $209,765 | Jan 15 | Janus Films | false |
| 133 | Gangster's Paradise: Jerusalema 2010 Re-release | - | - | - | $7,294 | 4 | $7,294 | Jun 11 | Anchor Bay Films | false |
| 134 | When You're Strange | - | - | - | $7,246 | 8 | $246,078 | Apr 9 | Abramorama | false |
| 135 | Breath Made Visible: Anna Halprin | - | - | - | $6,796 | 3 | $52,387 | Apr 2 | Argot Pictures | false |
| 136 | Finding Bliss | - | - | - | $6,783 | 1 | $6,783 | Jun 4 | Phase 4 Films | false |
| 137 | After the Cup: Sons of Sakhnin United | - | - | - | $6,759 | 3 | $11,538 | May 21 | Variance Films | false |
| 138 | Harlan: In the Shadow of Jew Suess | - | - | - | $6,452 | 5 | $54,305 | Mar 3 | Zeitgeist Films | false |
| 139 | Dancing Across Borders | - | - | - | $6,281 | 5 | $66,166 | Mar 26 | First Run | false |
| 140 | The Harimaya Bridge | - | - | - | $6,026 | 3 | $54,473 | Mar 12 | Eleven Arts | false |
| 141 | U2 3D | - | - | - | $5,784 | 686 | $10,363,341 | Jan 23 | National Geographic Entertainment | false |
| 142 | Whiz Kids | - | - | - | $5,286 | 2 | $5,386 | Jun 4 | Shadow Distribution | false |
| 143 | Speed-Dating | - | - | - | $5,240 | 1 | $5,240 | Jun 4 | Rockstone Releasing | false |
| 144 | The Girl on the Train | - | - | - | $4,035 | 10 | $208,023 | Jan 22 | Strand Releasing | false |
| 145 | The Nature of Existence | - | - | - | $4,009 | 4 | $54,645 | Jun 18 | Walking Shadows | false |
| 146 | Beetle Queen Conquers Tokyo | - | - | - | $3,766 | 3 | $32,308 | May 12 | Argot Pictures | false |
| 147 | October Country | - | - | - | $3,647 | 4 | $26,185 | Feb 12 | International Film Circuit | false |
| 148 | The Full Picture | - | - | - | $3,467 | 1 | $3,467 | Jun 11 | - | false |
| 149 | Terribly Happy | - | - | - | $3,121 | 9 | $170,943 | Feb 5 | Oscilloscope | false |
| 150 | Fresh | - | - | - | $3,113 | 3 | $25,115 | Apr 9 | - | false |
| 151 | Valley of the Heart's Delight | - | - | - | $2,910 | 8 | $119,290 | Apr 9 | Indican Pictures | false |
| 152 | North Face | - | - | - | $2,829 | 36 | $711,421 | Jan 29 | Music Box Films | false |
| 153 | The Blind Side | - | - | - | $2,643 | 3,407 | $255,959,475 | Nov 20 | Warner Bros. | false |
| 154 | Crazy Heart | - | - | - | $2,325 | 1,361 | $39,464,306 | Dec 16 | - | false |
| 155 | See What I'm Saying: The Deaf Entertainers Documentary | - | - | - | $2,000 | 21 | $118,206 | Mar 19 | Worldplay | false |
| 156 | The Runaways | - | - | - | $1,938 | 244 | $3,573,673 | Mar 19 | Apparition | false |
| 157 | Departures | - | - | - | $1,869 | 27 | $1,498,210 | May 29 | Regent Releasing | false |
| 158 | Spring Fever | - | - | - | $1,624 | 2 | $10,824 | Jun 4 | Strand Releasing | false |
| 159 | Daddy Longlegs | - | - | - | $1,521 | 2 | $21,766 | May 14 | IFC Films | false |
| 160 | Videocracy | - | - | - | $1,492 | 1 | $23,720 | Feb 12 | Kino International | false |
| 161 | A Town Called Panic | - | - | - | $1,454 | 10 | $165,509 | Dec 16 | Zeitgeist Films | false |
| 162 | American Grindhouse | - | - | - | $1,298 | 2 | $5,529 | Jun 18 | Lorber Films | false |
| 163 | Prodigal Sons | - | - | - | $1,225 | 11 | $73,544 | Feb 26 | First Run | false |
| 164 | 35 Shots of Rum | - | - | - | $888 | 5 | $177,511 | Sep 16 | The Cinema Guild | false |
| 165 | Small Change | - | - | - | $734 | 2 | $38,296 | Nov 24 | The Film Desk | false |
| 166 | The Living Wake | - | - | - | $714 | 1 | $12,232 | May 14 | Mangusta Productions | false |
| 167 | Behind the Burly Q | - | - | - | $642 | 2 | $23,889 | Apr 23 | First Run | false |
| 168 | Crude | - | - | - | $575 | 7 | $170,295 | Sep 9 | First Run | false |
| 169 | Galapagos | - | - | - | $513 | 14 | $18,630,372 | Oct 29 | IMAX | false |
| 170 | Dreamkiller | - | - | - | $480 | 3 | $15,514 | Feb 19 | Delaware Pictures | false |
| 171 | Feed the Fish | - | - | - | $426 | 4 | $101,170 | Apr 23 | Strand Releasing | false |
| 172 | Dream Boy | - | - | - | $325 | 1 | $6,534 | Mar 26 | Regent Releasing | false |
| 173 | Tru Loved | - | - | - | $275 | 4 | $9,467 | Oct 17 | Regent Releasing | false |
| 174 | NoBody's Perfect 2010 Re-release | - | - | - | $252 | 1 | $2,122 | Apr 16 | Lorber Films | false |
| 175 | The White Ribbon | - | - | - | $195 | 106 | $2,222,862 | Dec 30 | Sony Pictures Classics | false |
| 176 | Just Say Love | - | - | - | $139 | 1 | $3,944 | Mar 26 | Regent Releasing | false |
| 177 | Manuela and Manuel | - | - | - | $108 | 1 | $1,582 | Mar 26 | Regent Releasing | false |
| 178 | Promised Lands | - | - | - | $63 | 1 | $4,546 | Feb 5 | The Film Desk | false |
