| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Twilight | - | - | - | $1,051,003 | 56 | $1,290,455 | Jan 1 | Bazuca Films | false |
| 2 | Bolt | - | - | - | $1,039,076 | 62 | $1,788,695 | Dec 25 | Walt Disney Pictures | false |
| 3 | Yes Man | - | - | - | $560,173 | 43 | $929,148 | Jan 15 | Warner Bros. | false |
| 4 | The Curious Case of Benjamin Button | - | - | - | $555,351 | 36 | $1,109,721 | Jan 22 | Warner Bros. | false |
| 5 | Beverly Hills Chihuahua | - | - | - | $458,842 | 38 | $579,028 | Jan 8 | Walt Disney Pictures | false |
| 6 | Madagascar: Escape 2 Africa | - | - | - | $414,659 | 79 | $2,024,236 | Dec 4 | United International Pictures | false |
| 7 | The Day the Earth Stood Still | - | - | - | $363,482 | 67 | $1,099,037 | Dec 11 | 20th Century Fox International | false |
| 8 | Australia | - | - | - | $299,911 | 52 | $327,444 | Jan 8 | 20th Century Fox International | false |
| 9 | Marley & Me | - | - | - | $154,131 | 28 | $167,017 | Jan 15 | 20th Century Fox International | false |
| 10 | The Boy in the Striped Pajamas | - | - | - | $146,783 | 14 | $259,677 | Jan 15 | Walt Disney Pictures | false |
| 11 | Burn After Reading | - | - | - | $127,840 | 20 | $145,102 | Jan 8 | United International Pictures | false |
| 12 | Hotel for Dogs | - | - | - | $107,874 | 23 | $269,095 | Jan 22 | United International Pictures | false |
| 13 | Quantum of Solace | - | - | - | $88,220 | 55 | $949,223 | Nov 6 | Sony Pictures Releasing | false |
| 14 | El Regalo | - | - | - | $79,799 | 38 | $734,849 | Oct 2 | - | false |
| 15 | The Strangers | - | - | - | $58,697 | 13 | $115,005 | Jan 22 | Bazuca Films | false |
| 16 | Quarantine | - | - | - | $55,348 | 28 | $188,281 | Jan 29 | Sony Pictures Releasing | false |
| 17 | The Tale of Despereaux | - | - | - | $51,452 | 33 | $158,946 | Jan 29 | United International Pictures | false |
| 18 | High School Musical 3: Senior Year | - | - | - | $49,366 | 55 | $727,413 | Nov 20 | Walt Disney Pictures | false |
| 19 | Saw V | - | - | - | $48,663 | 30 | $309,625 | Dec 4 | Walt Disney Pictures | false |
| 20 | Bride Wars | - | - | - | $47,147 | 28 | $146,672 | Jan 29 | 20th Century Fox International | false |
| 21 | Revolutionary Road | - | - | - | $40,992 | 22 | $124,733 | Jan 29 | United International Pictures | false |
| 22 | In Bruges | - | - | - | $36,990 | 9 | $38,989 | Jan 15 | Bazuca Films | false |
| 23 | Che: Part One | - | - | - | $35,804 | 17 | $128,625 | Jan 29 | Bazuca Films | false |
| 24 | Four Christmases | - | - | - | $32,433 | 17 | $93,324 | Dec 18 | Warner Bros. | false |
| 25 | Body of Lies | - | - | - | $30,444 | 33 | $234,585 | Nov 20 | Warner Bros. | false |
| 26 | RocknRolla | - | - | - | $22,154 | 11 | $45,151 | Dec 25 | Warner Bros. | false |
| 27 | Dan in Real Life | - | - | - | $18,777 | 16 | $96,830 | Dec 11 | Bazuca Films | false |
| 28 | The Spirit | - | - | - | $18,706 | 10 | $22,575 | Jan 22 | Sony Pictures Releasing | false |
| 29 | Black Christmas | - | - | - | $15,918 | 10 | $45,991 | Dec 18 | Bazuca Films | false |
| 30 | A Girl Cut in Two | - | - | - | $13,526 | 4 | $36,516 | Dec 18 | Transeuropa | false |
| 31 | W. | - | - | - | $8,808 | 4 | $8,808 | Jan 22 | Impacto Cine | false |
| 32 | Muñeca | - | - | - | $7,761 | 17 | $68,205 | Dec 4 | Bazuca Films | false |
| 33 | Trade | - | - | - | $2,688 | 12 | $15,132 | Dec 25 | - | false |
| 34 | Lokas | - | - | - | $2,648 | 39 | $645,800 | Apr 3 | Andes Films | false |
| 35 | The Nightmare Before Christmas 2009 3D Release | - | - | - | $561 | 3 | $206,466 | Oct 23 | Walt Disney Pictures | false |
| 36 | Max Payne | - | - | - | $208 | 22 | $74,714 | Nov 27 | 20th Century Fox International | false |
| 37 | Irma Vap: O Retorno | - | - | - | $159 | 15 | $77,262 | Nov 13 | Bazuca Films | false |
| 38 | Pride and Glory | - | - | - | $66 | 15 | $36,564 | Dec 4 | Warner Bros. | false |
| 39 | El diario de Agustín | - | - | - | $24 | 1 | $5,675 | Dec 18 | Los Filmes de la Arcadia | false |
