| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | I Am Legend | - | - | - | $770,597 | 40 | $1,294,576 | Jan 17 | Warner Bros. | false |
| 2 | Enchanted | - | - | - | $699,101 | 40 | $1,426,461 | Dec 13 | Walt Disney Pictures | false |
| 3 | National Treasure: Book of Secrets | - | - | - | $634,343 | 43 | $1,033,173 | Dec 27 | Walt Disney Pictures | false |
| 4 | Alvin and the Chipmunks | - | - | - | $480,590 | 35 | $791,700 | Dec 20 | 20th Century Fox International | false |
| 5 | Chile puede | - | - | - | $347,594 | 40 | $365,966 | Jan 3 | Warner Bros. | false |
| 6 | The Golden Compass | - | - | - | $293,653 | 50 | $849,398 | Dec 13 | Warner Bros. | false |
| 7 | The Game Plan | - | - | - | $275,597 | 22 | $943,428 | Jan 17 | Walt Disney Pictures | false |
| 8 | The Heartbreak Kid | - | - | - | $233,205 | 28 | $481,654 | Dec 20 | United International Pictures | false |
| 9 | Love in the Time of Cholera | - | - | - | $205,796 | 27 | $383,805 | Jan 17 | 20th Century Fox International | false |
| 10 | Aliens vs. Predator: Requiem | - | - | - | $174,948 | 33 | $452,162 | Jan 24 | 20th Century Fox International | false |
| 11 | Bee Movie | - | - | - | $103,701 | 57 | $673,669 | Dec 6 | United International Pictures | false |
| 12 | 1408 | - | - | - | $100,009 | 20 | $203,975 | Dec 27 | United International Pictures | false |
| 13 | Hitman | - | - | - | $92,057 | 19 | $98,485 | Jan 10 | 20th Century Fox International | false |
| 14 | Pulentos, la película | - | - | - | $90,403 | 38 | $145,009 | Dec 27 | Bazuca Films | false |
| 15 | 30 Days of Night | - | - | - | $89,733 | 16 | $105,160 | Jan 10 | Sony Pictures Releasing | false |
| 16 | Beowulf | - | - | - | $59,347 | 37 | $675,440 | Nov 22 | Warner Bros. | false |
| 17 | Shattered | - | - | - | $52,431 | 19 | $53,126 | Jan 10 | Bazuca Films | false |
| 18 | Michael Clayton | - | - | - | $46,898 | 15 | $189,470 | Dec 6 | Bazuca Films | false |
| 19 | Bridge to Terabithia | - | - | - | $46,435 | 14 | $63,520 | Jan 3 | United International Pictures | false |
| 20 | I Now Pronounce You Chuck & Larry | - | - | - | $41,983 | 26 | $154,650 | Nov 22 | United International Pictures | false |
| 21 | Priceless | - | - | - | $36,433 | 7 | $38,792 | Jan 10 | Transeuropa | false |
| 22 | Saw IV | - | - | - | $33,128 | 27 | $286,824 | Dec 6 | Walt Disney Pictures | false |
| 23 | The Assassination of Jesse James by the Coward Robert Ford | - | - | - | $25,234 | 10 | $55,512 | Dec 27 | Warner Bros. | false |
| 24 | Venus | - | - | - | $24,403 | 6 | $24,842 | Jan 17 | Transeuropa | false |
| 25 | Lonely Hearts | - | - | - | $17,884 | 8 | $23,435 | Jan 24 | Bazuca Films | false |
| 26 | Private Fears in Public Places | - | - | - | $17,348 | 5 | $41,720 | Jan 24 | Four Films | false |
| 27 | Sleuth | - | - | - | $16,883 | 1 | $20,990 | Jan 10 | Sony Pictures Releasing | false |
| 28 | Gone Baby Gone | - | - | - | $15,063 | 4 | $30,917 | Jan 24 | Walt Disney Pictures | false |
| 29 | Lie with Me | - | - | - | $12,412 | 10 | $14,097 | Jan 24 | Los Filmes de la Arcadia | false |
| 30 | Stormbreaker | - | - | - | $11,274 | 8 | $11,274 | Jan 3 | Impacto Cine | false |
| 31 | Underdog | - | - | - | $11,205 | 29 | $506,231 | Oct 25 | Walt Disney Pictures | false |
| 32 | Orchestra Seats | - | - | - | $1,216 | 7 | $72,103 | Nov 8 | Transeuropa | false |
| 33 | Saint Ange 2006 Re-release | - | - | - | $802 | 9 | $129,826 | Oct 25 | Bazuca Films | false |
