| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Avatar | - | - | - | $31,770,778 | 856 | $93,746,295 | Jan 15 | 20th Century Fox International | false |
| 2 | Paranormal Activity | - | - | - | $9,153,419 | 411 | $9,153,419 | Feb 5 | Filmauro | false |
| 3 | Sorry If I Want to Marry You | - | - | - | $8,927,394 | 492 | $9,217,837 | Feb 12 | Medusa Distribuzione | false |
| 4 | Kiss Me Again | - | - | - | $8,051,279 | 584 | $12,373,612 | Jan 29 | Medusa Distribuzione | false |
| 5 | Alvin and the Chipmunks: The Squeakquel | - | - | - | $5,402,056 | 344 | $8,197,134 | Jan 29 | 20th Century Fox International | false |
| 6 | The Wolfman | - | - | - | $4,862,003 | 391 | $5,937,460 | Feb 19 | United International Pictures | false |
| 7 | Genitori & figli:) - Agitare bene prima dell'uso | - | - | - | $3,802,776 | 471 | $11,455,266 | Feb 26 | Filmauro | false |
| 8 | Up in the Air | - | - | - | $3,427,279 | 339 | $7,439,717 | Jan 22 | United International Pictures | false |
| 9 | The Concert | - | - | - | $2,977,603 | 139 | $4,825,505 | Feb 5 | BIM Distribuzione | false |
| 10 | Invictus | - | - | - | $2,647,257 | 418 | $9,063,387 | Feb 26 | Warner Bros. | false |
| 11 | The First Beautiful Thing | - | - | - | $2,387,404 | 350 | $9,115,665 | Jan 15 | Medusa Distribuzione | false |
| 12 | The Lovely Bones | - | - | - | $2,382,159 | 332 | $2,396,608 | Feb 12 | United International Pictures | false |
| 13 | The Youngest Son | - | - | - | $2,376,786 | 320 | $2,848,577 | Feb 19 | Medusa Distribuzione | false |
| 14 | Did You Hear About the Morgans? | - | - | - | $2,074,569 | 232 | $2,561,420 | Feb 19 | Sony Pictures Releasing | false |
| 15 | The Book of Eli | - | - | - | $1,800,564 | 331 | $3,916,301 | Feb 26 | 01 Distribution | false |
| 16 | Lilly the Witch: The Dragon and the Magic Book | - | - | - | $1,113,500 | 155 | $1,226,230 | Feb 12 | Walt Disney Pictures | false |
| 17 | Le missionnaire | - | - | - | $980,576 | 173 | $1,072,505 | Feb 19 | Eagle Pictures | false |
| 18 | Me, Them and Lara | - | - | - | $972,607 | 576 | $21,347,896 | Jan 5 | Warner Bros. | false |
| 19 | Bangkok Dangerous | - | - | - | $861,339 | 143 | $1,418,034 | Jan 29 | Eagle Pictures | false |
| 20 | The Man Who Will Come | - | - | - | $776,448 | 69 | $1,877,452 | Jan 22 | Mikado Film | false |
| 21 | The Fourth Kind | - | - | - | $712,105 | 155 | $2,426,800 | Jan 22 | Warner Bros. | false |
| 22 | A Single Man | - | - | - | $469,937 | 56 | $1,531,617 | Jan 15 | - | false |
| 23 | An Education | - | - | - | $452,937 | 37 | $536,758 | Feb 5 | Sony Pictures Releasing | false |
| 24 | Soul Kitchen | - | - | - | $433,805 | 100 | $2,371,166 | Jan 8 | BIM Distribuzione | false |
| 25 | Lourdes | - | - | - | $414,172 | 83 | $510,877 | Feb 11 | - | false |
| 26 | Nine | - | - | - | $257,639 | 250 | $1,604,773 | Jan 22 | 01 Distribution | false |
| 27 | Pet Pals: Marco Polo's Code | - | - | - | $206,223 | 172 | $994,776 | Jan 22 | 01 Distribution | false |
| 28 | The Hedgehog | - | - | - | $114,003 | 199 | $3,236,371 | Jan 5 | Eagle Pictures | false |
| 29 | Call of the Wild | - | - | - | $113,460 | 62 | $206,094 | Feb 19 | - | false |
| 30 | The Mouth of the Wolf | - | - | - | $100,603 | 17 | $179,376 | Feb 19 | BIM Distribuzione | false |
| 31 | Cloudy with a Chance of Meatballs | - | - | - | $56,804 | 308 | $6,448,099 | Dec 23 | Sony Pictures Releasing | false |
| 32 | First Snow 2010 Re-release | - | - | - | $51,385 | 16 | $189,218 | Jan 22 | Eagle Pictures | false |
| 33 | Alta infedeltà | - | - | - | $39,069 | - | $39,069 | Feb 26 | - | false |
| 34 | Sorority Row | - | - | - | $31,487 | 15 | $31,487 | Feb 26 | Eagle Pictures | false |
| 35 | Incendiary | - | - | - | $10,472 | 9 | $143,379 | Feb 26 | - | false |
| 36 | Welcome | - | - | - | $10,114 | 40 | $1,253,705 | Dec 11 | Teodora Film | false |
| 37 | Promise Me This | - | - | - | $10,054 | 9 | $29,504 | Feb 19 | - | false |
| 38 | Alvin and the Chipmunks | - | - | - | $5,510 | 256 | $5,481,266 | Jan 18 | 20th Century Fox International | false |
| 39 | After School | - | - | - | $5,035 | 7 | $5,035 | Feb 26 | - | false |
| 40 | The Hurt Locker | - | - | - | $4,517 | 70 | $234,231 | Oct 10 | Warner Bros. | false |
| 41 | Looking for Eric | - | - | - | $4,383 | 80 | $2,330,354 | Dec 4 | BIM Distribuzione | false |
| 42 | Baaria | - | - | - | $2,778 | 527 | $14,686,170 | Sep 25 | Medusa Distribuzione | false |
| 43 | Planet 51 | - | - | - | $2,313 | 255 | $3,405,781 | Nov 20 | - | false |
| 44 | Brothers | - | - | - | $1,240 | 201 | $3,266,025 | Dec 23 | 01 Distribution | false |
| 45 | The Cézanne Affair/The Man Who Will Come | - | - | - | $1,199 | 253 | $2,239,181 | Dec 4 | 01 Distribution | false |
| 46 | Gravehopping | - | - | - | $1,135 | 2 | $43,057 | Jul 4 | - | false |
