| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Avatar | - | - | - | $196,243 | 18 | $1,454,156 | Dec 17 | 20th Century Fox International | false |
| 2 | The Wolfman | - | - | - | $94,353 | 12 | $142,291 | Feb 11 | Universal Pictures International (UPI) | false |
| 3 | Old Dogs | - | - | - | $83,254 | 5 | $137,191 | Jan 28 | Walt Disney Pictures | false |
| 4 | Percy Jackson & the Olympians: The Lightning Thief | - | - | - | $72,704 | 12 | $121,320 | Feb 11 | 20th Century Fox International | false |
| 5 | Tooth Fairy | - | - | - | $43,032 | 8 | $174,809 | Jan 14 | 20th Century Fox International | false |
| 6 | Valentine's Day | - | - | - | $35,362 | 5 | $45,439 | Feb 11 | Warner Bros. | false |
| 7 | Toy Story 2 2009 Re-release | - | - | - | $32,064 | 4 | $32,064 | Feb 18 | Walt Disney Pictures | false |
| 8 | Invictus | - | - | - | $29,852 | 4 | $33,539 | Feb 4 | Warner Bros. | false |
| 9 | Saw VI | - | - | - | $27,674 | 4 | $27,674 | Feb 4 | Walt Disney Pictures | false |
| 10 | Sherlock Holmes | - | - | - | $23,247 | 7 | $133,079 | Jan 14 | Warner Bros. | false |
| 11 | Toy Story 2009 Re-release | - | - | - | $22,007 | 4 | $32,214 | Feb 11 | Walt Disney Pictures | false |
| 12 | The Hurt Locker | - | - | - | $16,875 | 2 | $72,208 | Feb 18 | Trade International | false |
| 13 | Edge of Darkness | - | - | - | $14,338 | 7 | $45,517 | Feb 25 | Warner Bros. | false |
| 14 | Ninja Assassin | - | - | - | $11,662 | 4 | $11,662 | Feb 18 | Warner Bros. | false |
| 15 | Search for Paradise | - | - | - | $10,616 | 6 | $101,879 | Jan 7 | - | false |
| 16 | Drag Me to Hell | - | - | - | $9,943 | 5 | $18,328 | Jan 28 | Universal Pictures International (UPI) | false |
| 17 | All About Steve | - | - | - | $8,184 | 4 | $18,159 | Feb 25 | 20th Century Fox International | false |
| 18 | Sorority Row | - | - | - | $7,030 | 6 | $12,324 | Feb 25 | Manfer Films | false |
| 19 | Nine | - | - | - | $6,891 | 4 | $27,248 | Jan 21 | Sony Pictures Releasing | false |
| 20 | Alvin and the Chipmunks: The Squeakquel | - | - | - | $5,450 | 10 | $271,964 | Dec 25 | 20th Century Fox International | false |
| 21 | Couples Retreat | - | - | - | $5,226 | 4 | $9,736 | Feb 25 | Universal Pictures International (UPI) | false |
| 22 | Flawless | - | - | - | $4,738 | 2 | $4,738 | Feb 18 | Trade International | false |
| 23 | Armored | - | - | - | $4,305 | 4 | $10,323 | Jan 28 | Sony Pictures Releasing | false |
| 24 | The Twilight Saga: New Moon | - | - | - | $3,101 | 10 | $203,967 | Jan 1 | Manfer Films | false |
| 25 | Planet 51 | - | - | - | $2,055 | 3 | $39,030 | Jan 7 | Trade International | false |
| 26 | The Princess and the Frog | - | - | - | $1,826 | 8 | $138,395 | Jan 1 | Walt Disney Pictures | false |
| 27 | The Host 2010 Re-release | - | - | - | $1,546 | 2 | $1,546 | Feb 25 | - | false |
| 28 | Paranoid Park | - | - | - | $973 | 2 | $973 | Feb 18 | - | false |
