| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | The Bucket List | - | - | - | $1,043,742 | 70 | $1,982,902 | Feb 7 | Warner Bros. | false |
| 2 | The Game Plan | - | - | - | $730,446 | 58 | $1,519,256 | Feb 14 | Walt Disney Pictures | false |
| 3 | Explosive Brigade: Pirate Mission | - | - | - | $688,131 | 96 | $763,987 | Feb 1 | Argentina Sono Film S.A.C.I. | false |
| 4 | National Treasure: Book of Secrets | - | - | - | $552,301 | 90 | $1,701,941 | Jan 17 | Walt Disney Pictures | false |
| 5 | Cloverfield | - | - | - | $530,886 | 45 | $635,660 | Feb 7 | United International Pictures | false |
| 6 | Enchanted | - | - | - | $474,598 | 108 | $2,862,455 | Jan 3 | Walt Disney Pictures | false |
| 7 | Sweeney Todd: The Demon Barber of Fleet Street | - | - | - | $464,542 | 46 | $651,305 | Feb 14 | Warner Bros. | false |
| 8 | Charlie Wilson's War | - | - | - | $457,450 | 45 | $872,501 | Jan 24 | United International Pictures | false |
| 9 | An American Haunting | - | - | - | $454,326 | 39 | $529,788 | Jan 31 | Distribution Company | false |
| 10 | The Water Horse | - | - | - | $422,097 | 38 | $590,991 | Feb 7 | Sony Pictures Releasing | false |
| 11 | Atonement | - | - | - | $386,628 | 43 | $533,834 | Feb 7 | United International Pictures | false |
| 12 | Eastern Promises | - | - | - | $275,499 | 43 | $432,196 | Feb 14 | Distribution Company | false |
| 13 | 27 Dresses | - | - | - | $256,944 | 53 | $288,586 | Feb 7 | 20th Century Fox International | false |
| 14 | I Am Legend | - | - | - | $247,796 | 91 | $2,075,757 | Dec 27 | Warner Bros. | false |
| 15 | Juno | - | - | - | $245,432 | 41 | $474,042 | Feb 14 | Alfa Films | false |
| 16 | Love in the Time of Cholera | - | - | - | $227,050 | 33 | $603,059 | Jan 17 | 20th Century Fox International | false |
| 17 | There Will Be Blood | - | - | - | $197,365 | 36 | $520,135 | Feb 21 | Walt Disney Pictures | false |
| 18 | Alvin and the Chipmunks | - | - | - | $183,537 | 69 | $833,808 | Jan 3 | 20th Century Fox International | false |
| 19 | Rambo | - | - | - | $173,681 | 49 | $324,433 | Feb 21 | CDI Films | false |
| 20 | Aliens vs. Predator: Requiem | - | - | - | $170,730 | 41 | $708,036 | Jan 10 | 20th Century Fox International | false |
| 21 | Spider-Man 3 | - | - | - | $130,665 | 202 | $4,584,691 | May 3 | Sony Pictures Releasing | false |
| 22 | 1408 | - | - | - | $101,145 | 37 | $262,789 | Jan 24 | United International Pictures | false |
| 23 | American Gangster | - | - | - | $100,304 | 54 | $793,526 | Jan 3 | United International Pictures | false |
| 24 | Hitman | - | - | - | $86,723 | 26 | $188,585 | Jan 24 | 20th Century Fox International | false |
| 25 | Away from Her | - | - | - | $83,170 | 21 | $183,918 | Feb 21 | Distribution Company | false |
| 26 | The Heartbreak Kid | - | - | - | $56,957 | 33 | $914,034 | Nov 8 | United International Pictures | false |
| 27 | Hannibal Rising | - | - | - | $54,105 | 27 | $89,287 | Feb 21 | United International Pictures | false |
| 28 | Gone Baby Gone | - | - | - | $42,134 | 21 | $436,926 | Nov 22 | Walt Disney Pictures | false |
| 29 | Bratz | - | - | - | $41,281 | 27 | $44,700 | Feb 14 | Pachamama Cine | false |
| 30 | I Do: How to Get Married and Stay Single | - | - | - | $37,449 | 7 | $71,375 | Jan 24 | Alfa Films | false |
| 31 | Sleuth | - | - | - | $28,037 | 12 | $166,205 | Jan 10 | Sony Pictures Releasing | false |
| 32 | The Cave of the Yellow Dog 2008 Re-release | - | - | - | $27,276 | 4 | $29,703 | Jan 31 | IFA | false |
| 33 | The Golden Compass | - | - | - | $23,636 | 84 | $1,421,819 | Dec 13 | Distribution Company | false |
| 34 | My Best Friend | - | - | - | $16,621 | 16 | $123,823 | Jan 3 | Alfa Films | false |
| 35 | Miss Potter | - | - | - | $15,047 | 6 | $15,047 | Jan 31 | United International Pictures | false |
| 36 | I Could Never Be Your Woman | - | - | - | $15,004 | 34 | $302,572 | Jan 3 | CDI Films | false |
| 37 | Giants of Valdes | - | - | - | $12,616 | 33 | $84,495 | Jan 17 | Primer Plano Film Group | false |
| 38 | Possible Lives | - | - | - | $11,273 | 5 | $19,236 | Feb 7 | Primer Plano Film Group | false |
| 39 | The Kite Runner | - | - | - | $9,909 | 12 | $11,419 | Feb 14 | United International Pictures | false |
| 40 | Bee Movie | - | - | - | $9,495 | 101 | $1,481,104 | Dec 6 | United International Pictures | false |
| 41 | 4 Months, 3 Weeks and 2 Days | - | - | - | $7,059 | 12 | $203,767 | Dec 6 | Pachamama Cine | false |
| 42 | The Assassination of Jesse James by the Coward Robert Ford | - | - | - | $6,597 | 15 | $158,043 | Nov 29 | Warner Bros. | false |
| 43 | Goya's Ghosts | - | - | - | $5,693 | 4 | $14,176 | Jan 24 | Alfa Films | false |
| 44 | Café Lumière 2007 Re-release | - | - | - | $4,794 | 3 | $51,258 | Dec 13 | 791 Cine | false |
| 45 | Bordertown | - | - | - | $4,728 | 32 | $60,948 | Jan 17 | Distribution Company | false |
| 46 | Bridge to Terabithia | - | - | - | $3,549 | 36 | $101,169 | Jan 10 | United International Pictures | false |
| 47 | Tres minutos | - | - | - | $3,386 | 5 | $6,691 | Feb 21 | Primer Plano Film Group | false |
| 48 | Beowulf | - | - | - | $3,053 | 47 | $904,033 | Nov 22 | Warner Bros. | false |
| 49 | After the Wedding | - | - | - | $2,049 | 11 | $107,601 | Nov 22 | Alfa Films | false |
| 50 | Lions for Lambs | - | - | - | $1,688 | 42 | $509,908 | Nov 15 | 20th Century Fox International | false |
| 51 | Shortbus | - | - | - | $821 | 5 | $30,712 | Nov 1 | Distribution Company | false |
| 52 | August Rush | - | - | - | $817 | 42 | $70,284 | Jan 10 | Distribution Company | false |
| 53 | Encarnacion | - | - | - | $699 | 9 | $41,526 | Oct 11 | Distribution Company | false |
| 54 | Underdog | - | - | - | $588 | 46 | $886,546 | Oct 4 | Walt Disney Pictures | false |
| 55 | Lights in the Dusk | - | - | - | $587 | 22 | $52,423 | Sep 27 | Alfa Films | false |
| 56 | Retribution | - | - | - | $451 | 20 | $115,072 | Dec 13 | Pachamama Cine | false |
| 57 | Suspiros del corazón | - | - | - | $443 | 4 | $8,429 | Jan 10 | Primer Plano Film Group | false |
| 58 | Rendition | - | - | - | $311 | 33 | $420,070 | Nov 1 | Distribution Company | false |
| 59 | The Flock | - | - | - | $270 | 30 | $187,463 | Dec 6 | CDI Films | false |
| 60 | Hechos, No Palabras | - | - | - | $259 | 1 | $2,749 | Jan 10 | Primer Plano Film Group | false |
| 61 | Days of Glory | - | - | - | $253 | 5 | $18,890 | Jan 3 | Alfa Films | false |
| 62 | The Black Dahlia | - | - | - | $233 | 6 | $62,360 | Nov 22 | United International Pictures | false |
| 63 | The Hitcher | - | - | - | $215 | 30 | $138,291 | Dec 6 | Distribution Company | false |
| 64 | ¿De quién es el portaligas? | - | - | - | $202 | 36 | $86,948 | Sep 20 | Primer Plano Film Group | false |
| 65 | Superbad | - | - | - | $185 | 30 | $396,284 | Nov 22 | Sony Pictures Releasing | false |
| 66 | Fierro | - | - | - | $153 | 74 | $155,289 | Nov 8 | Primer Plano Film Group | false |
| 67 | The Other | - | - | - | $148 | 14 | $118,075 | May 10 | Distribution Company | false |
| 68 | At Five in the Afternoon | - | - | - | $139 | 3 | $16,114 | Nov 29 | 791 Cine | false |
| 69 | Pirates of the Caribbean: At World's End | - | - | - | $117 | 258 | $4,889,474 | May 24 | Buena Vista International | false |
| 70 | Ratatouille | - | - | - | $115 | 164 | $3,843,055 | Jul 5 | Buena Vista International | false |
| 71 | Who Says It's Easy? | - | - | - | $106 | 54 | $1,265,601 | Feb 8 | Primer Plano Film Group | false |
| 72 | A Stray Girlfriend | - | - | - | $99 | 12 | $48,453 | Jun 7 | Primer Plano Film Group | false |
| 73 | Vitus | - | - | - | $97 | 12 | $48,522 | Nov 15 | CDI Films | false |
| 74 | Estrellas | - | - | - | $87 | 5 | $14,426 | Dec 13 | Primer Plano Film Group | false |
| 75 | The Bow | - | - | - | $72 | 3 | $931,554 | Jan 25 | Alfa Films | false |
| 76 | Música nocturna | - | - | - | $62 | 4 | $25,650 | Nov 15 | Primer Plano Film Group | false |
| 77 | City in Heat | - | - | - | $37 | 3 | $32,697 | Mar 22 | Alfa Films | false |
| 78 | Quiéreme | - | - | - | $34 | 16 | $62,172 | Nov 15 | Alfa Films | false |
| 79 | Whisper | - | - | - | $33 | 28 | $112,121 | Nov 29 | Alfa Films | false |
| 80 | Hacer patria | - | - | - | $11 | 4 | $9,149 | Aug 9 | Distribution Company | false |
