| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Night at the Museum | - | - | - | $13,909,965 | 471 | $16,188,874 | Feb 2 | 20th Century Fox International | false |
| 2 | Notte prima degli esami - Oggi | - | - | - | $11,724,116 | 604 | $16,544,856 | Feb 14 | 01 Distribution | false |
| 3 | Hannibal Rising | - | - | - | $7,127,802 | 365 | $7,566,213 | Feb 9 | Filmauro | false |
| 4 | Manual of Love 2 | - | - | - | $6,043,139 | 590 | $26,266,668 | Jan 19 | Filmauro | false |
| 5 | The Holiday | - | - | - | $5,284,127 | 319 | $6,079,376 | Feb 9 | Universal Pictures International (UPI) | false |
| 6 | Saturn in Opposition | - | - | - | $4,236,497 | 399 | $10,652,524 | Feb 23 | Medusa Distribuzione | false |
| 7 | The Pursuit of Happyness | - | - | - | $4,017,870 | 441 | $21,309,984 | Jan 12 | Medusa Distribuzione | false |
| 8 | A Dinner for Them to Meet | - | - | - | $3,834,956 | 262 | $4,173,202 | Feb 2 | Medusa Distribuzione | false |
| 9 | Blood Diamond | - | - | - | $3,246,273 | 266 | $5,701,333 | Jan 26 | Warner Bros. | false |
| 10 | Step Up | - | - | - | $2,474,716 | 238 | $4,743,789 | Jan 26 | Medusa Distribuzione | false |
| 11 | Music and Lyrics | - | - | - | $2,179,742 | 326 | $5,080,907 | Feb 23 | Warner Bros. | false |
| 12 | Arthur and the Invisibles | - | - | - | $2,123,134 | 345 | $2,656,590 | Feb 9 | 01 Distribution | false |
| 13 | Alpha Dog | - | - | - | $1,178,907 | 190 | $2,378,866 | Feb 23 | Moviemax | false |
| 14 | Mi fido di te | - | - | - | $830,828 | 110 | $830,828 | Feb 9 | Medusa Distribuzione | false |
| 15 | Miss Potter | - | - | - | $603,999 | 146 | $603,999 | Feb 2 | Eagle Pictures | false |
| 16 | Notes on a Scandal | - | - | - | $593,828 | 94 | $1,983,521 | Feb 23 | 20th Century Fox International | false |
| 17 | Letters from Iwo Jima | - | - | - | $556,212 | 55 | $987,775 | Feb 16 | Warner Bros. | false |
| 18 | Bobby | - | - | - | $548,042 | 147 | $2,190,025 | Jan 19 | 01 Distribution | false |
| 19 | Barnyard | - | - | - | $469,229 | 150 | $1,119,394 | Feb 23 | Universal Pictures International (UPI) | false |
| 20 | The Last King of Scotland | - | - | - | $419,717 | 87 | $862,325 | Feb 16 | 20th Century Fox International | false |
| 21 | Inland Empire | - | - | - | $332,125 | 26 | $462,031 | Feb 9 | BIM Distribuzione | false |
| 22 | The Page Turner | - | - | - | $285,469 | 29 | $497,134 | Feb 9 | Mikado Film | false |
| 23 | The Science of Sleep | - | - | - | $267,675 | 50 | $760,566 | Jan 19 | Mikado Film | false |
| 24 | Breaking and Entering | - | - | - | $260,381 | 77 | $260,381 | Feb 9 | Buena Vista International | false |
| 25 | Stranger Than Fiction | - | - | - | $256,744 | 96 | $325,935 | Feb 2 | Sony Pictures Releasing | false |
| 26 | Black Book | - | - | - | $242,200 | 69 | $332,869 | Feb 2 | DNC Entertainment | false |
| 27 | Apocalypto | - | - | - | $229,072 | 326 | $8,677,937 | Jan 5 | Eagle Pictures | false |
| 28 | The Painted Veil | - | - | - | $220,471 | 65 | $610,692 | Feb 23 | Eagle Pictures | false |
| 29 | The Covenant | - | - | - | $196,241 | 52 | $196,241 | Feb 16 | Sony Pictures Releasing | false |
| 30 | Rocky Balboa | - | - | - | $167,988 | 331 | $8,928,978 | Jan 12 | 20th Century Fox International | false |
| 31 | Casino Royale | - | - | - | $151,996 | 407 | $10,959,793 | Jan 5 | Sony Pictures Releasing | false |
| 32 | The Boss of It All | - | - | - | $134,864 | 58 | $1,224,987 | Jan 5 | Lucky Red | false |
| 33 | Dreamgirls | - | - | - | $107,249 | 172 | $687,157 | Jan 26 | Universal Pictures International (UPI) | false |
| 34 | Little Red Flowers | - | - | - | $77,560 | 22 | $295,370 | Jan 12 | Istituto Luce | false |
| 35 | Flushed Away | - | - | - | $55,879 | 281 | $9,133,030 | Dec 22 | United International Pictures | false |
| 36 | A Good Year | - | - | - | $32,256 | 267 | $7,205,533 | Dec 15 | Medusa Distribuzione | false |
| 37 | After the Wedding | - | - | - | $28,490 | 33 | $614,345 | Dec 22 | Teodora Film | false |
