| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Night at the Museum | - | - | - | $1,307,661 | 92 | $3,216,799 | Jan 18 | 20th Century Fox International | false |
| 2 | Babel | - | - | - | $739,030 | 47 | $1,738,658 | Jan 18 | United International Pictures | false |
| 3 | Who Says It's Easy? | - | - | - | $632,346 | 54 | $1,265,601 | Feb 8 | Primer Plano Film Group | false |
| 4 | Hoodwinked! | - | - | - | $568,692 | 44 | $822,570 | Feb 8 | Alfa Films | false |
| 5 | Blood Diamond | - | - | - | $530,850 | 46 | $895,324 | Feb 8 | Warner Bros. | false |
| 6 | Apocalypto | - | - | - | $505,758 | 30 | $862,406 | Feb 1 | 20th Century Fox International | false |
| 7 | Deja Vu | - | - | - | $419,980 | 56 | $1,840,967 | Jan 4 | Buena Vista International | false |
| 8 | The Pursuit of Happyness | - | - | - | $250,419 | 32 | $303,107 | Feb 1 | Sony Pictures Releasing | false |
| 9 | The Queen | - | - | - | $236,134 | 34 | $848,709 | Feb 22 | Distribution Company | false |
| 10 | Flushed Away | - | - | - | $229,494 | 90 | $1,612,596 | Jan 4 | United International Pictures | false |
| 11 | Borat | - | - | - | $196,523 | 20 | $264,589 | Feb 8 | 20th Century Fox International | false |
| 12 | The Holiday | - | - | - | $191,476 | 42 | $688,224 | Jan 11 | United International Pictures | false |
| 13 | Perfume: The Story of a Murderer | - | - | - | $166,642 | 24 | $266,292 | Feb 15 | Distribution Company | false |
| 14 | Letters from Iwo Jima | - | - | - | $162,509 | 14 | $307,431 | Feb 15 | Warner Bros. | false |
| 15 | Marie Antoinette | - | - | - | $152,772 | 14 | $296,330 | Jan 25 | Sony Pictures Releasing | false |
| 16 | Charlotte's Web | - | - | - | $151,131 | 40 | $310,456 | Jan 25 | United International Pictures | false |
| 17 | The Good Shepherd | - | - | - | $145,801 | 41 | $381,638 | Feb 22 | United International Pictures | false |
| 18 | A Prairie Home Companion | - | - | - | $134,830 | 12 | $163,976 | Feb 1 | Distribution Company | false |
| 19 | Flags of Our Fathers | - | - | - | $92,283 | 15 | $208,156 | Jan 25 | Warner Bros. | false |
| 20 | Eragon | - | - | - | $69,818 | 70 | $1,097,072 | Jan 4 | 20th Century Fox International | false |
| 21 | The Last King of Scotland | - | - | - | $63,456 | 14 | $163,322 | Feb 15 | 20th Century Fox International | false |
| 22 | The Departed | - | - | - | $54,823 | 76 | $2,011,780 | Nov 16 | Warner Bros. | false |
| 23 | Dragones: destino de fuego | - | - | - | $49,612 | 40 | $86,002 | Feb 1 | Pachamama Cine | false |
| 24 | Pan's Labyrinth | - | - | - | $44,552 | 10 | $187,916 | Jan 4 | Warner Bros. | false |
| 25 | See No Evil | - | - | - | $33,675 | 24 | $70,333 | Feb 22 | Alfa Films | false |
| 26 | Hollywoodland | - | - | - | $26,641 | 14 | $34,217 | Feb 1 | Buena Vista International | false |
| 27 | Dreamgirls | - | - | - | $22,986 | 9 | $47,969 | Feb 8 | United International Pictures | false |
| 28 | The Grudge 2 | - | - | - | $20,497 | 40 | $225,045 | Jan 11 | Alfa Films | false |
| 29 | Tsotsi | - | - | - | $17,064 | 14 | $69,524 | Jan 25 | Alfa Films | false |
| 30 | Tenacious D in the Pick of Destiny | - | - | - | $16,967 | 21 | $72,086 | Jan 25 | Distribution Company | false |
| 31 | Little Children | - | - | - | $16,837 | 20 | $249,020 | Jan 4 | Distribution Company | false |
