| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Rain Man | - | - | - | $27,894,206 | 1,590 | $172,825,435 | Dec 16 | Metro-Goldwyn-Mayer (MGM) | false |
| 2 | Three Fugitives | - | - | - | $23,553,929 | 1,374 | $40,586,886 | Jan 27 | Walt Disney Studios Motion Pictures | false |
| 3 | Beaches | - | - | - | $18,908,025 | 1,122 | $57,041,866 | Dec 23 | Walt Disney Studios Motion Pictures | false |
| 4 | The 'Burbs | - | - | - | $18,132,632 | 1,956 | $36,601,993 | Feb 17 | Universal Pictures | false |
| 5 | The Fly II | - | - | - | $15,348,946 | 1,528 | $20,021,322 | Feb 10 | Twentieth Century Fox | false |
| 6 | Her Alibi | - | - | - | $14,732,414 | 1,429 | $18,699,037 | Feb 3 | Warner Bros. | false |
| 7 | Twins | - | - | - | $12,797,545 | 1,659 | $111,938,388 | Dec 9 | Universal Pictures | false |
| 8 | Working Girl | - | - | - | $12,163,991 | 1,149 | $63,779,477 | Dec 23 | Twentieth Century Fox | false |
| 9 | Bill & Ted's Excellent Adventure | - | - | - | $11,354,306 | 1,321 | $40,485,039 | Feb 17 | Orion Pictures | false |
| 10 | Mississippi Burning | - | - | - | $11,281,328 | 1,134 | $34,603,943 | Dec 9 | Orion Pictures | false |
| 11 | Who's Harry Crumb? | - | - | - | $10,982,364 | 1,198 | $10,982,364 | Feb 3 | TriStar Pictures | false |
| 12 | The Naked Gun: From the Files of Police Squad! | - | - | - | $10,715,230 | 1,969 | $78,756,177 | Dec 2 | Paramount Pictures | false |
| 13 | Dangerous Liaisons | - | - | - | $10,504,798 | 762 | $34,670,720 | Dec 23 | Warner Bros. | false |
| 14 | Cousins | - | - | - | $10,467,718 | 747 | $22,026,369 | Feb 10 | Paramount Pictures | false |
| 15 | The Accidental Tourist | - | - | - | $10,153,643 | 954 | $32,632,093 | Dec 23 | Warner Bros. | false |
| 16 | Tap | - | - | - | $6,512,550 | 587 | $9,114,702 | Feb 10 | TriStar Pictures | false |
| 17 | Dirty Rotten Scoundrels | - | - | - | $5,747,442 | 1,515 | $42,039,085 | Dec 16 | Orion Pictures | false |
| 18 | True Believer | - | - | - | $5,282,831 | 897 | $8,742,750 | Feb 17 | Columbia Pictures | false |
| 19 | Torch Song Trilogy | - | - | - | $4,733,264 | 135 | $4,865,997 | Dec 16 | New Line Cinema | false |
| 20 | The Mighty Quinn | - | - | - | $4,557,214 | 234 | $4,557,214 | Feb 17 | Metro-Goldwyn-Mayer (MGM) | false |
| 21 | Oliver & Company | - | - | - | $4,025,227 | 1,503 | $53,279,055 | Nov 18 | Walt Disney Studios Motion Pictures | false |
| 22 | Kinjite: Forbidden Subjects | - | - | - | $3,416,846 | 320 | $3,416,846 | Feb 3 | Cannon Film Distributors | false |
| 23 | Bird | - | - | - | $2,138,486 | 93 | $2,181,286 | Sep 30 | Warner Bros. | false |
| 24 | Physical Evidence | - | - | - | $1,938,052 | 695 | $3,560,932 | Jan 27 | Columbia Pictures | false |
| 25 | The Toxic Avenger Part II | - | - | - | $764,016 | 15 | $792,966 | Feb 24 | Troma | false |
| 26 | American Ninja 3: Blood Hunt | - | - | - | $679,900 | 140 | $902,152 | Feb 24 | Cannon Film Distributors | false |
| 27 | Parents | - | - | - | $617,497 | 94 | $870,532 | Jan 27 | Vestron Pictures | false |
| 28 | Manifesto | - | - | - | $59,914 | 1 | $70,060 | Jan 27 | Cannon Film Distributors | false |
| 29 | Bert Rigby, You're a Fool | - | - | - | $43,325 | 23 | $75,868 | Feb 24 | Warner Bros. | false |
| 30 | High Hopes | - | - | - | $29,960 | 25 | $1,192,322 | Feb 24 | Skouras Pictures | false |
| 31 | Cohen and Tate | - | - | - | $22,316 | 75 | $64,227 | Jan 27 | Hemdale | false |
| 32 | Powwow Highway | - | - | - | $10,370 | 14 | $283,747 | Feb 24 | Warner Bros. | false |
| 33 | Paperhouse | - | - | - | $8,540 | 9 | $241,278 | Feb 17 | Vestron Pictures | false |
