| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Godzilla vs. Kong | - | - | - | $76,961,746 | 3,084 | $100,916,094 | Mar 31 | Warner Bros. | false |
| 2 | Demon Slayer: Kimetsu no Yaiba - The Movie: Mugen Train | - | - | - | $29,568,279 | 2,087 | $49,505,008 | Apr 23 | FUNimation Entertainment | false |
| 3 | Mortal Kombat | - | - | - | $25,150,000 | 3,114 | $42,326,031 | Apr 23 | Warner Bros. | false |
| 4 | Nobody | - | - | - | $14,127,445 | 2,567 | $27,568,035 | Mar 26 | Universal Pictures | false |
| 5 | The Unholy | - | - | - | $12,370,983 | 2,057 | $15,532,137 | Apr 2 | Screen Gems | false |
| 6 | Raya and the Last Dragon | - | - | - | $10,869,069 | 2,375 | $54,723,032 | Mar 5 | Walt Disney Studios Motion Pictures | false |
| 7 | Tom & Jerry | - | - | - | $5,642,476 | 2,563 | $46,536,687 | Feb 26 | Warner Bros. | false |
| 8 | Voyagers | - | - | - | $3,045,819 | 1,996 | $3,149,935 | Apr 9 | Lionsgate | false |
| 9 | The Girl Who Believes in Miracles | - | - | - | $2,622,725 | 1,012 | $3,163,362 | Apr 2 | Atlas Distribution Company | false |
| 10 | The Courier | - | - | - | $2,403,136 | 1,641 | $6,613,432 | Mar 19 | Roadside Attractions | false |
| 11 | Chaos Walking | - | - | - | $1,415,963 | 2,132 | $13,287,908 | Mar 5 | Lionsgate | false |
| 12 | The Croods: A New Age | - | - | - | $1,347,372 | 2,211 | $58,568,815 | Nov 25 | Universal Pictures | false |
| 13 | In the Earth | - | - | - | $1,033,207 | 571 | $1,113,723 | Apr 16 | Neon | false |
| 14 | Minari | - | - | - | $846,625 | 912 | $3,110,580 | Feb 12 | A24 | false |
| 15 | Together Together | - | - | - | $800,555 | 665 | $1,437,938 | Apr 23 | Bleecker Street Media | false |
| 16 | The Marksman | - | - | - | $711,871 | 2,018 | $15,566,093 | Jan 15 | Open Road Films (II) | false |
| 17 | Separation | - | - | - | $684,608 | 1,911 | $4,509,143 | Apr 30 | Open Road Films (II) | false |
| 18 | French Exit | - | - | - | $640,165 | 493 | $741,895 | Feb 12 | Sony Pictures Classics | false |
| 19 | The Father | - | - | - | $527,779 | 933 | $2,122,771 | Feb 26 | Sony Pictures Classics | false |
| 20 | Wonder Woman 1984 | - | - | - | $508,565 | 2,218 | $46,801,036 | Dec 25 | Warner Bros. | false |
| 21 | Promising Young Woman | - | - | - | $455,635 | 1,448 | $6,460,965 | Dec 25 | Focus Features | false |
| 22 | 2021 Oscar Nominated Short Films: Live Action | - | - | - | $432,893 | 184 | $443,050 | Apr 2 | Magnolia Pictures | false |
| 23 | Scott Pilgrim vs. the World 10th Anniversary (2021 Re-release) | - | - | - | $339,685 | 448 | $1,867,625 | - | Universal Pictures | false |
| 24 | The Little Things | - | - | - | $285,154 | 2,206 | $15,342,746 | Jan 29 | Warner Bros. | false |
| 25 | Boogie | - | - | - | $256,675 | 1,272 | $4,178,620 | Mar 5 | Focus Features | false |
| 26 | Wrong Turn | - | - | - | $233,916 | 259 | $1,251,184 | Jan 26 | Saban Films | false |
| 27 | Judas and the Black Messiah | - | - | - | $200,653 | 1,906 | $5,478,009 | Feb 12 | Warner Bros. | false |
| 28 | Lamb of God: The Concert Film | - | - | - | $167,508 | 138 | $744,813 | Mar 12 | Excel Entertainment | false |
| 29 | Monster Hunter | - | - | - | $149,264 | 1,817 | $15,162,470 | Dec 18 | Screen Gems | false |
| 30 | SAS: Rise of the Black Swan | - | - | - | $146,329 | 189 | $146,329 | Apr 16 | Vertical Entertainment | false |
| 31 | The War with Grandpa | - | - | - | $140,769 | 2,365 | $21,277,892 | Oct 9 | 101 Studios | false |
| 32 | Held | - | - | - | $121,900 | 129 | $142,817 | Apr 9 | Magnolia Pictures | false |
| 33 | The Truffle Hunters | - | - | - | $103,428 | 105 | $521,202 | Mar 5 | Sony Pictures Classics | false |
| 34 | Four Good Days | - | - | - | $99,804 | 489 | $837,849 | Apr 30 | Vertical Entertainment | false |
| 35 | News of the World | - | - | - | $92,145 | 1,986 | $12,668,325 | Dec 25 | Universal Pictures | false |
| 36 | Shiva Baby | - | - | - | $81,087 | 27 | $159,294 | Apr 2 | Utopia | false |
| 37 | Six Minutes to Midnight | - | - | - | $60,670 | 145 | $132,500 | Mar 26 | IFC Films | false |
| 38 | Dutch | - | - | - | $54,985 | 202 | $404,371 | Mar 12 | Faith Media Distribution | false |
| 39 | City of Lies | - | - | - | $53,703 | 502 | $572,493 | Mar 19 | Saban Films | false |
| 40 | Tenet | - | - | - | $32,230 | 2,930 | $58,504,105 | Sep 3 | Warner Bros. | false |
| 41 | Limbo | - | - | - | $31,040 | 213 | $224,405 | Apr 30 | Focus Features | false |
| 42 | Monday | - | - | - | $30,201 | 54 | $30,932 | Apr 16 | IFC Films | false |
| 43 | Trigger Point | - | - | - | $29,262 | 77 | $29,262 | Apr 16 | Screen Media Films | false |
| 44 | Jakob's Wife | - | - | - | $27,588 | 101 | $27,588 | Apr 16 | - | false |
| 45 | The Resort | - | - | - | $26,739 | 114 | $191,996 | Apr 30 | Vertical Entertainment | false |
| 46 | Gunda | - | - | - | $24,797 | 35 | $115,691 | Apr 16 | Neon | false |
| 47 | Moffie | - | - | - | $24,520 | 51 | $24,520 | Apr 9 | IFC Films | false |
| 48 | We Broke Up | - | - | - | $15,063 | 35 | $15,063 | Apr 16 | Vertical Entertainment | false |
| 49 | Counter Column | - | - | - | $14,864 | 7 | $32,323 | Oct 16 | Not That Kind of Movie Productions | false |
| 50 | Cliff Walkers | - | - | - | $13,577 | 65 | $152,972 | Apr 30 | CMC Pictures | false |
| 51 | Long Weekend | - | - | - | $12,440 | 821 | $1,018,532 | Mar 12 | Stage 6 Films | false |
| 52 | 100% Wolf | - | - | - | $10,514 | 124 | $658,764 | Oct 9 | Viva Pictures | false |
| 53 | Senior Moment | - | - | - | $9,913 | 57 | $41,598 | Mar 26 | Screen Media Films | false |
| 54 | The Boonies | - | - | - | $5,499 | 2 | $6,887 | Mar 31 | Indican Pictures | false |
| 55 | Blithe Spirit | - | - | - | $5,113 | 239 | $282,500 | Feb 19 | IFC Films | false |
| 56 | Blood Brothers: Civil War | - | - | - | $4,893 | 2 | $5,191 | Apr 2 | Indican Pictures | false |
| 57 | Bill Traylor: Chasing Ghosts | - | - | - | $4,143 | 2 | $4,504 | Apr 16 | Kino Lorber | false |
| 58 | A Writer's Odyssey | - | - | - | $3,240 | 117 | $160,013 | Feb 12 | CMC Pictures | false |
| 59 | Slalom | - | - | - | $2,796 | 4 | $2,788 | Apr 9 | Kino Lorber | false |
| 60 | About Endlessness | - | - | - | $2,288 | 17 | $51,386 | Apr 30 | Magnolia Pictures | false |
| 61 | Mystery of the Kingdom of God | - | - | - | $2,174 | 106 | $17,316 | Mar 26 | Atlas Distribution Company | false |
| 62 | Things Don't Stay Fixed | - | - | - | $1,610 | 3 | $5,430 | Mar 26 | Indican Pictures | false |
| 63 | Bang! Bang! | - | - | - | $1,348 | 1 | $6,390 | Oct 23 | Indican Pictures | false |
| 64 | Last Call | - | - | - | $1,313 | 110 | $48,144 | Mar 19 | IFC Films | false |
| 65 | The Mauritanian | - | - | - | $812 | 287 | $836,536 | Feb 12 | STX Entertainment | false |
| 66 | Endless Rain | - | - | - | $793 | 14 | $7,334 | Apr 30 | Sony Pictures Releasing | false |
| 67 | The Incredible 25th Year of Mitzi Bearclaw | - | - | - | $695 | 2 | $10,368 | Feb 12 | Indican Pictures | false |
| 68 | Come True | - | - | - | $600 | 96 | $62,080 | Mar 12 | IFC Films | false |
| 69 | Safer at Home | - | - | - | $516 | 79 | $95,643 | Feb 26 | Vertical Entertainment | false |
| 70 | Supernova | - | - | - | $464 | 330 | $234,220 | Jan 29 | Bleecker Street Media | false |
| 71 | No Place | - | - | - | $363 | 1 | $4,194 | Mar 5 | Indican Pictures | false |
| 72 | The Vigil | - | - | - | $332 | 55 | $50,439 | Feb 26 | IFC Films | false |
| 73 | My Zoe | - | - | - | $281 | 237 | $52,733 | Feb 26 | Blue Fox Entertainment | false |
| 74 | Stray | - | - | - | $271 | 17 | $13,325 | Mar 5 | Magnolia Pictures | false |
| 75 | My Salinger Year | - | - | - | $270 | 123 | $54,730 | Mar 5 | IFC Films | false |
| 76 | First Signal | - | - | - | $170 | 1 | $880 | Mar 26 | The Ashton Times | false |
| 77 | The World to Come | - | - | - | $140 | 277 | $116,143 | Feb 12 | Bleecker Street Media | false |
| 78 | The Shade Shepherd | - | - | - | $120 | 1 | $4,409 | Oct 16 | Indican Pictures | false |
| 79 | Abandoned: Angelique's Isle | - | - | - | $100 | 1 | $6,055 | Feb 19 | Indican Pictures | false |
