| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Clash of the Titans | - | - | - | $154,500 | 9 | $233,655 | Apr 16 | Warner Bros. | false |
| 2 | Alice in Wonderland | - | - | - | $107,239 | 11 | $509,177 | Mar 5 | Walt Disney Pictures | false |
| 3 | How to Train Your Dragon | - | - | - | $105,380 | 10 | $212,859 | Mar 26 | Paramount Pictures International | false |
| 4 | The Bounty Hunter | - | - | - | $76,912 | 5 | $122,335 | Mar 26 | Sony Pictures Releasing | false |
| 5 | La despedida | - | - | - | $61,147 | 5 | $102,717 | Mar 26 | - | false |
| 6 | The Book of Eli | - | - | - | $47,184 | 5 | $106,178 | Mar 19 | Sony Pictures Releasing | false |
| 7 | Night Runner | - | - | - | $45,870 | 5 | $50,592 | Apr 9 | - | false |
| 8 | Everybody's Fine | - | - | - | $41,962 | 5 | $44,534 | Apr 2 | Walt Disney Pictures | false |
| 9 | Shutter Island | - | - | - | $35,308 | 7 | $144,361 | Apr 23 | Paramount Pictures International | false |
| 10 | Date Night | - | - | - | $27,427 | 7 | $137,952 | Apr 23 | 20th Century Fox International | false |
| 11 | Edge of Darkness | - | - | - | $25,238 | 7 | $127,710 | Feb 26 | Warner Bros. | false |
| 12 | The Wave | - | - | - | $21,526 | 4 | $73,874 | Apr 16 | - | false |
| 13 | The Blind Side | - | - | - | $18,540 | 4 | $76,906 | Mar 5 | Warner Bros. | false |
| 14 | The Men Who Stare at Goats | - | - | - | $15,257 | 2 | $15,758 | Apr 9 | Sony Pictures Releasing | false |
| 15 | The Widows of Thursdays | - | - | - | $15,250 | 7 | $74,737 | Mar 5 | - | false |
| 16 | The Imaginarium of Doctor Parnassus | - | - | - | $15,136 | 3 | $16,198 | Apr 2 | Sony Pictures Releasing | false |
| 17 | Saw VI | - | - | - | $10,101 | 5 | $22,086 | Mar 26 | Walt Disney Pictures | false |
| 18 | Avatar | - | - | - | $10,024 | 11 | $1,274,650 | Dec 18 | 20th Century Fox International | false |
| 19 | Tooth Fairy | - | - | - | $9,337 | 5 | $73,077 | Feb 26 | 20th Century Fox International | false |
| 20 | Let it Rain | - | - | - | $7,368 | 2 | $15,072 | Mar 19 | - | false |
| 21 | Away We Go | - | - | - | $7,316 | 1 | $9,719 | Apr 9 | Universal Pictures International (UPI) | false |
| 22 | Amelia | - | - | - | $6,788 | 2 | $13,334 | Mar 26 | 20th Century Fox International | false |
| 23 | The Last Deadly Mission | - | - | - | $6,439 | 4 | $6,439 | Apr 16 | - | false |
| 24 | Daybreakers | - | - | - | $4,879 | 3 | $4,879 | Apr 16 | - | false |
| 25 | Hiroshima | - | - | - | $4,033 | 1 | $7,251 | Apr 16 | - | false |
| 26 | Two Lovers | - | - | - | $3,248 | 3 | $15,817 | Mar 19 | - | false |
| 27 | The Hurt Locker | - | - | - | $3,057 | 4 | $88,196 | Feb 5 | - | false |
| 28 | An Education | - | - | - | $2,741 | 4 | $60,876 | Feb 19 | Sony Pictures Releasing | false |
| 29 | The Secret in Their Eyes | - | - | - | $2,505 | 2 | $397,437 | Oct 16 | - | false |
| 30 | A Serious Man | - | - | - | $2,444 | 1 | $25,622 | Feb 26 | Universal Pictures International (UPI) | false |
| 31 | Couples Retreat | - | - | - | $2,416 | 6 | $33,593 | Mar 12 | Universal Pictures International (UPI) | false |
| 32 | Alvin and the Chipmunks: The Squeakquel | - | - | - | $2,301 | 6 | $175,570 | Jan 1 | 20th Century Fox International | false |
| 33 | Did You Hear About the Morgans? | - | - | - | $1,794 | 5 | $77,261 | Feb 26 | Sony Pictures Releasing | false |
| 34 | Igor | - | - | - | $1,278 | 3 | $4,663 | Mar 26 | - | false |
| 35 | A Prophet | - | - | - | $1,256 | 1 | $1,621 | Apr 23 | Sony Pictures Releasing | false |
| 36 | Lo que sé de Lola 2010 Re-release | - | - | - | $754 | 1 | $1,068 | Apr 9 | - | false |
| 37 | Cirque du Freak: The Vampire's Assistant | - | - | - | $250 | 5 | $4,159 | Mar 19 | Universal Pictures International (UPI) | false |
