| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Beetlejuice | - | - | - | $43,483,688 | 1,582 | $73,707,461 | Mar 30 | Warner Bros. | false |
| 2 | Biloxi Blues | - | - | - | $22,494,165 | 1,330 | $43,184,798 | Mar 25 | Universal Pictures | false |
| 3 | Bright Lights, Big City | - | - | - | $16,118,077 | 1,199 | $16,118,077 | Apr 1 | United Artists | false |
| 4 | The Fox and the Hound 1988 Re-release | - | - | - | $16,072,087 | 1,567 | $23,556,988 | Mar 25 | Walt Disney Studios Motion Pictures | false |
| 5 | The Seventh Sign | - | - | - | $15,833,354 | 1,258 | $18,875,011 | Apr 1 | TriStar Pictures | false |
| 6 | Colors | - | - | - | $14,766,260 | 1,388 | $46,616,067 | Apr 15 | Orion Pictures | false |
| 7 | Moonstruck | - | - | - | $12,222,002 | 1,178 | $80,640,528 | Dec 18 | Metro-Goldwyn-Mayer (MGM) | false |
| 8 | Good Morning, Vietnam | - | - | - | $11,910,695 | 1,598 | $123,922,370 | Dec 25 | Walt Disney Studios Motion Pictures | false |
| 9 | The Last Emperor | - | - | - | $11,016,210 | 877 | $43,984,230 | Nov 20 | Columbia Pictures | false |
| 10 | Johnny Be Good | - | - | - | $10,235,789 | 1,194 | $17,550,399 | Mar 25 | Orion Pictures | false |
| 11 | Above the Law | - | - | - | $10,211,286 | 868 | $18,869,631 | Apr 8 | Warner Bros. | false |
| 12 | Bad Dreams | - | - | - | $9,797,098 | 1,185 | $9,797,098 | Apr 8 | Twentieth Century Fox | false |
| 13 | Return to Snowy River | - | - | - | $7,344,573 | 1,121 | $13,687,027 | Apr 15 | Walt Disney Studios Motion Pictures | false |
| 14 | Police Academy 5: Assignment: Miami Beach | - | - | - | $6,982,470 | 1,700 | $19,510,371 | Mar 18 | Warner Bros. | false |
| 15 | Stand and Deliver | - | - | - | $5,829,981 | 472 | $13,994,920 | Mar 11 | Warner Bros. | false |
| 16 | Casual Sex? | - | - | - | $5,795,332 | 1,265 | $12,277,096 | Apr 22 | Universal Pictures | false |
| 17 | The Milagro Beanfield War | - | - | - | $5,647,007 | 437 | $13,825,794 | Mar 18 | Universal Pictures | false |
| 18 | Fatal Attraction | - | - | - | $5,612,019 | 1,401 | $156,645,693 | Sep 18 | Paramount Pictures | false |
| 19 | The Unbearable Lightness of Being | - | - | - | $5,242,069 | 140 | $10,006,806 | Feb 5 | Orion Pictures | false |
| 20 | Masquerade | - | - | - | $4,335,120 | 1,031 | $15,855,828 | Mar 11 | Metro-Goldwyn-Mayer (MGM) | false |
| 21 | A New Life | - | - | - | $4,246,843 | 796 | $7,721,852 | Mar 25 | Paramount Pictures | false |
| 22 | D.O.A. | - | - | - | $4,129,700 | 908 | $12,706,478 | Mar 18 | Walt Disney Studios Motion Pictures | false |
| 23 | The Unholy | - | - | - | $3,765,255 | 1,189 | $6,337,299 | Apr 22 | Vestron Pictures | false |
| 24 | Broadcast News | - | - | - | $3,702,642 | 848 | $51,249,404 | Dec 18 | Twentieth Century Fox | false |
| 25 | Three Men and a Baby | - | - | - | $3,259,421 | 1,813 | $167,780,960 | Nov 25 | Walt Disney Studios Motion Pictures | false |
| 26 | Hope and Glory | - | - | - | $2,755,282 | 328 | $10,021,120 | Oct 16 | Columbia Pictures | false |
| 27 | 18 Again! | - | - | - | $2,567,099 | 1,152 | $2,567,099 | Apr 8 | New World Pictures | false |
| 28 | Vice Versa | - | - | - | $2,387,681 | 1,225 | $13,664,060 | Mar 11 | Columbia Pictures | false |
| 29 | Hairspray | - | - | - | $2,220,353 | 227 | $6,671,108 | Feb 26 | New Line Cinema | false |
| 30 | Appointment with Death | - | - | - | $960,040 | 465 | $960,040 | Apr 15 | Cannon Film Distributors | false |
| 31 | A Time of Destiny | - | - | - | $754,427 | 220 | $1,212,487 | Apr 22 | Columbia Pictures | false |
| 32 | Sunset | - | - | - | $730,860 | 1,024 | $4,594,452 | Apr 29 | TriStar Pictures | false |
| 33 | Critters 2: The Main Course | - | - | - | $642,346 | 1,114 | $3,813,293 | Apr 29 | New Line Cinema | false |
| 34 | Lady in White | - | - | - | $358,029 | 107 | $1,705,139 | Apr 22 | New Century | false |
| 35 | Plain Clothes | - | - | - | $289,323 | 193 | $289,323 | Apr 15 | Paramount Pictures | false |
| 36 | Sammy and Rosie Get Laid | - | - | - | $258,321 | 15 | $1,196,336 | Oct 30 | Cinecom Pictures | false |
| 37 | Two Moon Junction | - | - | - | $225,200 | 458 | $1,547,397 | Apr 29 | Lorimar Motion Pictures | false |
| 38 | Mondo New York | - | - | - | $193,209 | 1 | $193,209 | Apr 22 | Fourth and Broadway | false |
| 39 | Little Nikita | - | - | - | $118,077 | 376 | $1,733,070 | Mar 18 | Columbia Pictures | false |
| 40 | Stormy Monday | - | - | - | $61,830 | 49 | $1,791,328 | Apr 22 | Atlantic Releasing Corporation | false |
| 41 | White Mischief | - | - | - | $47,637 | 87 | $3,107,551 | Apr 22 | Columbia Pictures | false |
| 42 | The Lighthorsemen | - | - | - | $33,779 | 16 | $33,779 | Apr 8 | Cinecom Pictures | false |
| 43 | The Moderns | - | - | - | $33,235 | 28 | $2,011,497 | Apr 15 | Alive Films | false |
| 44 | Bellman and True | - | - | - | $30,423 | 8 | $226,944 | Apr 1 | Island Pictures | false |
| 45 | Powaqqatsi | - | - | - | $11,770 | 22 | $589,244 | Apr 29 | Cannon Film Distributors | false |
| 46 | Consuming Passions | - | - | - | $9,552 | 5 | $118,206 | Apr 6 | The Samuel Goldwyn Company | false |
| 47 | Wings of Desire | - | - | - | $8,754 | 29 | $3,210,139 | Apr 29 | Orion Classics | false |
| 48 | Da | - | - | - | $4,986 | 1 | $644,532 | Apr 29 | - | false |
