| Rank
| Title
| Lifetime Gross | Max Theaters | Opening | Open Th | Release Date | Distributor
|
|---|
| 1 | Avatar | $749,766,139 | 3,461 | $77,025,481 | 3,452 | Dec 18, 2009 | Twentieth Century Fox |
| 2 | Million Dollar Baby | $100,492,203 | 2,375 | $179,953 | 8 | Dec 15, 2004 | Warner Bros. |
| 3 | Born on the Fourth of July | $70,001,698 | 1,434 | $172,021 | 5 | Dec 22, 1989 | Universal Pictures |
| 4 | The Bone Collector | $66,518,655 | 2,623 | $16,712,020 | 2,587 | Nov 5, 1999 | Universal Pictures |
| 5 | The Theory of Everything | $35,893,537 | 1,220 | $208,763 | 5 | Nov 7, 2014 | Focus Features |
| 6 | Coming Home | $32,653,905 | - | - | - | Feb 15, 1978 | United Artists |
| 7 | Extreme Measures | $17,380,126 | 2,298 | $6,906,546 | 2,298 | Sep 27, 1996 | Sony Pictures Releasing |
| 8 | My Left Foot | $14,743,391 | 510 | $41,165 | 2 | Nov 10, 1989 | Miramax |
| 9 | Gattaca | $12,532,777 | 1,279 | $4,320,202 | 1,279 | Oct 24, 1997 | Sony Pictures Releasing |
| 10 | The Other Side of the Mountain: Part II | $11,565,678 | - | - | - | Jan 1, 1978 | Universal Pictures |
| 11 | The Intouchables | $10,198,820 | 194 | $103,507 | 4 | May 25, 2012 | The Weinstein Company |
| 12 | Whose Life Is It Anyway? | $8,206,145 | 615 | - | - | Dec 2, 1981 | Metro-Goldwyn-Mayer (MGM) |
| 13 | Mac and Me | $6,424,112 | 1,317 | $2,061,464 | 1,314 | Aug 12, 1988 | Orion Pictures |
| 14 | The Sessions | $6,002,451 | 516 | $113,467 | 4 | Oct 19, 2012 | - |
| 15 | Monkey Shines | $5,344,577 | 1,181 | $1,902,024 | 1,181 | Jul 29, 1988 | Orion Pictures |
| 16 | Passion Fish | $4,814,619 | 191 | $14,385 | 2 | Dec 9, 1992 | Miramax |
| 17 | Resurrection | $3,910,019 | 417 | $308,068 | 417 | Sep 26, 1980 | Universal Pictures |
| 18 | The Sea Inside | $2,104,923 | 99 | $55,681 | 23 | Dec 17, 2004 | Fine Line Features |
| 19 | Rust and Bone | $2,062,027 | 168 | $27,154 | 2 | Nov 23, 2012 | Sony Pictures Classics |
| 20 | The Waterdance | $1,723,319 | 60 | $138,313 | 33 | May 15, 1992 | The Samuel Goldwyn Company |
| 21 | Murderball | $1,531,154 | 97 | $57,286 | 8 | Jul 8, 2005 | THINKFilm |
| 22 | Don't Worry, He Won't Get Far on Foot | $1,441,705 | 266 | $83,339 | 4 | Jul 13, 2018 | Amazon Studios |
| 23 | Breathe | $490,131 | 315 | $22,285 | 4 | Oct 13, 2017 | Bleecker Street Media |
| 24 | War Eagle, Arkansas | $123,670 | 7 | $16,467 | 7 | Jun 12, 2009 | Hannover House |
| 25 | Rory O'Shea Was Here | $23,844 | 7 | $6,079 | 3 | Feb 4, 2005 | Focus Features |
| 26 | Quid Pro Quo | $11,864 | 4 | $7,395 | 4 | Jun 13, 2008 | Magnolia Pictures |
| 27 | Oasis | $10,304 | 2 | $6,485 | 2 | May 7, 2004 | - |
