| Rank
| Title
| Lifetime Gross | Max Theaters | Opening | Open Th | Release Date | Distributor
|
|---|
| 1 | The Twilight Saga: Breaking Dawn - Part 1 | $281,287,133 | 4,066 | $138,122,261 | 4,061 | Nov 18, 2011 | Summit Entertainment |
| 2 | Knocked Up | $148,768,917 | 2,975 | $30,690,990 | 2,871 | Jun 1, 2007 | Universal Pictures |
| 3 | Juno | $143,495,265 | 2,534 | $413,869 | 7 | Dec 5, 2007 | - |
| 4 | Father of the Bride Part II | $76,594,107 | 2,148 | $11,134,978 | 1,949 | Dec 8, 1995 | Walt Disney Studios Motion Pictures |
| 5 | Nine Months | $69,684,532 | 1,795 | $12,522,240 | 1,458 | Jul 14, 1995 | Twentieth Century Fox |
| 6 | Baby Mama | $60,494,212 | 2,627 | $17,407,110 | 2,543 | Apr 25, 2008 | Universal Pictures |
| 7 | Precious | $47,566,524 | 1,003 | $1,872,458 | 18 | Nov 6, 2009 | Lionsgate |
| 8 | The Unborn | $42,670,410 | 2,359 | $19,810,585 | 2,357 | Jan 9, 2009 | Universal Pictures |
| 9 | What to Expect When You're Expecting | $41,152,203 | 3,021 | $10,547,068 | 3,021 | May 18, 2012 | Lionsgate |
| 10 | Legion | $40,168,080 | 2,476 | $17,501,625 | 2,476 | Jan 22, 2010 | Screen Gems |
| 11 | The Nativity Story | $37,629,831 | 3,083 | $8,025,000 | 3,083 | Dec 1, 2006 | New Line Cinema |
| 12 | The Back-up Plan | $37,490,007 | 3,280 | $12,201,710 | 3,280 | Apr 23, 2010 | CBS Films |
| 13 | Junior | $36,763,355 | 1,896 | $9,803,145 | 1,749 | Nov 23, 1994 | Universal Pictures |
| 14 | Children of Men | $35,552,383 | 1,524 | $501,003 | 16 | Dec 25, 2006 | Universal Pictures |
| 15 | Bridget Jones's Baby | $24,252,420 | 2,930 | $8,571,785 | 2,927 | Sep 16, 2016 | Universal Pictures |
| 16 | Waitress | $19,074,800 | 707 | $92,034 | 4 | May 2, 2007 | - |
| 17 | My Baby's Daddy | $17,669,317 | 1,448 | $7,800,000 | 1,447 | Jan 9, 2004 | Miramax |
| 18 | Seed of Chucky | $17,083,732 | 2,062 | $8,800,000 | 2,061 | Nov 12, 2004 | Rogue Pictures |
| 19 | She's Having a Baby | $16,031,707 | 1,133 | $3,827,520 | 925 | Feb 5, 1988 | Paramount Pictures |
| 20 | Devil's Due | $15,821,461 | 2,544 | $8,308,220 | 2,544 | Jan 17, 2014 | Twentieth Century Fox |
| 21 | The Next Best Thing | $14,990,582 | 2,035 | $5,870,387 | 2,007 | Mar 3, 2000 | Paramount Pictures |
| 22 | Sugar & Spice | $13,305,101 | 2,150 | $5,891,176 | 2,150 | Jan 26, 2001 | New Line Cinema |
| 23 | Bella | $8,070,537 | 457 | $1,328,448 | 165 | Oct 26, 2007 | Roadside Attractions |
| 24 | She's So Lovely | $7,281,450 | 844 | $3,020,015 | 824 | Aug 27, 1997 | Miramax |
| 25 | Maria Full of Grace | $6,529,624 | 127 | $139,066 | 7 | Jul 16, 2004 | Fine Line Features |
| 26 | The Unborn | $1,159,578 | 67 | $179,080 | 55 | Mar 29, 1991 | Concorde Pictures |
| 27 | The Brothers Solomon | $900,926 | 700 | $508,601 | 700 | Sep 7, 2007 | Screen Gems |
| 28 | Unexpected | $23,986 | 32 | - | - | Jul 24, 2015 | The Film Arcade |
| 29 | 17 Girls | $15,123 | 10 | $4,449 | 10 | Sep 21, 2012 | Strand Releasing |
| 30 | Hell Baby | $8,785 | 10 | $4,980 | 10 | Sep 6, 2013 | Millennium Entertainment |
| 31 | Small, Beautifully Moving Parts | $8,631 | 1 | $3,087 | 1 | May 11, 2012 | Long Shot Factory |
| 32 | Misconceptions | $6,892 | 2 | $3,796 | 2 | Jan 22, 2010 | Regent Releasing |
| 33 | Come Out and Play | $2,638 | 10 | $1,600 | 10 | Mar 22, 2013 | Cinedigm Entertainment Group |
| 34 | Miss Conception | $2,134 | 3 | $1,342 | 3 | Jun 6, 2008 | First Look International |
