| Rank
| Title
| Lifetime Gross | Max Theaters | Opening | Open Th | Release Date | Distributor
|
|---|
| 1 | Scooby-Doo | $153,294,164 | 3,447 | $54,155,312 | 3,447 | Jun 14, 2002 | Warner Bros. |
| 2 | Marley & Me | $143,153,751 | 3,505 | $36,357,586 | 3,480 | Dec 25, 2008 | Twentieth Century Fox |
| 3 | 101 Dalmatians | $136,189,294 | 2,901 | $33,504,025 | 2,794 | Nov 27, 1996 | Walt Disney Studios Motion Pictures |
| 4 | Beverly Hills Chihuahua | $94,514,402 | 3,239 | $29,300,465 | 3,215 | Oct 3, 2008 | Walt Disney Studios Motion Pictures |
| 5 | Cats & Dogs | $93,385,515 | 3,040 | $21,707,617 | 3,040 | Jul 4, 2001 | Warner Bros. |
| 6 | Scooby-Doo 2: Monsters Unleashed | $84,216,833 | 3,312 | $29,438,331 | 3,312 | Mar 26, 2004 | Warner Bros. |
| 7 | Eight Below | $81,612,565 | 3,122 | $20,188,176 | 3,066 | Feb 17, 2006 | Walt Disney Studios Motion Pictures |
| 8 | Snow Dogs | $81,172,560 | 2,454 | $17,814,259 | 2,302 | Jan 18, 2002 | Walt Disney Studios Motion Pictures |
| 9 | Hotel for Dogs | $73,034,460 | 3,271 | $17,012,212 | 3,271 | Jan 16, 2009 | DreamWorks |
| 10 | Turner & Hooch | $71,079,915 | 1,888 | $12,211,042 | 1,877 | Jul 28, 1989 | Walt Disney Studios Motion Pictures |
| 11 | 102 Dalmatians | $66,957,026 | 2,704 | $19,883,351 | 2,704 | Nov 22, 2000 | Walt Disney Studios Motion Pictures |
| 12 | A Dog's Purpose | $64,508,620 | 3,178 | $18,222,810 | 3,059 | Jan 27, 2017 | Universal Pictures |
| 13 | The Call of the Wild | $62,342,368 | 3,914 | $24,791,624 | 3,752 | Feb 21, 2020 | 20th Century Studios |
| 14 | The Shaggy Dog | $61,123,569 | 3,501 | $16,310,058 | 3,501 | Mar 10, 2006 | Walt Disney Studios Motion Pictures |
| 15 | Beethoven | $57,114,049 | 1,938 | $7,587,565 | 1,688 | Apr 3, 1992 | Universal Pictures |
| 16 | Beethoven's 2nd | $53,443,066 | 2,048 | $6,017,225 | 2,026 | Dec 17, 1993 | Universal Pictures |
| 17 | Clifford the Big Red Dog | $48,947,356 | 3,700 | $16,627,491 | 3,700 | Nov 10, 2021 | Paramount Pictures |
| 18 | Underdog | $43,760,605 | 3,013 | $11,585,121 | 3,013 | Aug 3, 2007 | Walt Disney Studios Motion Pictures |
| 19 | Cats & Dogs: The Revenge of Kitty Galore | $43,585,753 | 3,705 | $12,279,363 | 3,705 | Jul 30, 2010 | Warner Bros. |
| 20 | K-9 | $43,247,647 | 1,706 | $7,471,035 | 1,677 | Apr 28, 1989 | Universal Pictures |
| 21 | John Wick | $43,037,835 | 2,589 | $14,415,922 | 2,589 | Oct 24, 2014 | Lionsgate |
| 22 | Max | $42,656,255 | 2,870 | $12,155,254 | 2,855 | Jun 26, 2015 | Warner Bros. |
| 23 | A Dog's Way Home | $42,004,346 | 3,090 | $11,251,263 | 3,090 | Jan 11, 2019 | Sony Pictures Releasing |
| 24 | Homeward Bound: The Incredible Journey | $41,833,324 | 1,798 | $60,672 | 2 | Feb 5, 1993 | Walt Disney Studios Motion Pictures |
| 25 | Benji | $39,552,000 | - | - | - | Oct 25, 1974 | - |
| 26 | Good Boy | $37,667,746 | 3,225 | $13,107,022 | 3,225 | Oct 10, 2003 | Metro-Goldwyn-Mayer (MGM) |
| 27 | Alpha | $35,857,181 | 2,881 | $10,352,512 | 2,719 | Aug 17, 2018 | Studio 8 |
| 28 | White Fang | $34,793,160 | 1,259 | $5,640,712 | 1,108 | Jan 18, 1991 | Walt Disney Studios Motion Pictures |
| 29 | My Dog Skip | $34,134,641 | 2,331 | $56,943 | 5 | Jan 14, 2000 | Warner Bros. |
| 30 | Marmaduke | $33,644,788 | 3,213 | $11,599,661 | 3,213 | Jun 4, 2010 | Twentieth Century Fox |
| 31 | See Spot Run | $33,357,476 | 2,656 | $9,715,102 | 2,656 | Mar 2, 2001 | Warner Bros. |
| 32 | Homeward Bound II: Lost in San Francisco | $32,772,492 | 2,129 | $8,605,649 | 2,119 | Mar 8, 1996 | Walt Disney Studios Motion Pictures |
| 33 | Because of Winn-Dixie | $32,647,042 | 3,188 | $10,208,431 | 3,188 | Feb 18, 2005 | Twentieth Century Fox |
| 34 | The Art of Racing in the Rain | $26,395,642 | 2,765 | $8,137,584 | 2,765 | Aug 9, 2019 | Twentieth Century Fox |
| 35 | Air Bud | $23,144,499 | 1,795 | $4,878,632 | 1,795 | Aug 1, 1997 | Walt Disney Studios Motion Pictures |
| 36 | A Dog's Journey | $22,782,371 | 3,279 | $8,030,085 | 3,267 | May 17, 2019 | Universal Pictures |
| 37 | Benji the Hunted | $22,257,624 | 1,188 | $21,530 | 1 | Jun 5, 1987 | Walt Disney Studios Motion Pictures |
| 38 | Cujo | $21,156,152 | 1,293 | $6,114,899 | 1,239 | Aug 12, 1983 | Warner Bros. |
| 39 | Iron Will | $21,006,361 | 2,036 | $5,313,406 | 1,901 | Jan 14, 1994 | Walt Disney Studios Motion Pictures |
| 40 | Best in Show | $18,715,392 | 497 | $413,436 | 13 | Sep 29, 2000 | Warner Bros. |
| 41 | Show Dogs | $17,857,020 | 3,212 | $6,023,972 | 3,212 | May 18, 2018 | - |
| 42 | For the Love of Benji | $17,732,000 | - | - | - | Jan 1, 1977 | Twentieth Century Fox |
| 43 | Seven Psychopaths | $15,024,049 | 1,480 | $4,174,915 | 1,480 | Oct 12, 2012 | CBS Films |
| 44 | Firehouse Dog | $13,932,383 | 2,881 | $3,838,916 | 2,860 | Apr 4, 2007 | Twentieth Century Fox |
| 45 | Megan Leavey | $13,406,883 | 1,956 | $3,810,867 | 1,956 | Jun 9, 2017 | Bleecker Street Media |
| 46 | Man's Best Friend | $12,974,636 | 1,230 | $3,861,079 | 1,220 | Nov 19, 1993 | New Line Cinema |
| 47 | Far from Home: The Adventures of Yellow Dog | $11,642,946 | 1,219 | $4,231,917 | 1,217 | Jan 13, 1995 | Twentieth Century Fox |
| 48 | The Adventures of Milo and Otis | $10,351,534 | 915 | $1,708,915 | 914 | Jun 15, 1990 | Columbia Pictures |
| 49 | Air Bud: Golden Receiver | $10,224,116 | 1,669 | $2,603,726 | 1,669 | Aug 14, 1998 | Miramax |
| 50 | Lassie | $9,979,683 | 1,785 | $3,201,843 | 1,785 | Jul 22, 1994 | Paramount Pictures |
| 51 | White Fang 2: Myth of the White Wolf | $8,878,839 | 1,877 | $2,692,624 | 1,853 | Apr 15, 1994 | Walt Disney Studios Motion Pictures |
| 52 | Bingo | $8,667,684 | 933 | $2,141,360 | 923 | Aug 9, 1991 | TriStar Pictures |
| 53 | Zeus and Roxanne | $7,233,324 | 1,745 | $2,755,382 | 1,745 | Jan 24, 1997 | Metro-Goldwyn-Mayer (MGM) |
| 54 | Dog Days | $6,809,080 | 2,442 | $2,554,766 | 2,442 | Aug 8, 2018 | LD Entertainment |
| 55 | A-X-L | $6,501,381 | 1,710 | $2,798,229 | 1,710 | Aug 24, 2018 | - |
| 56 | Oh Heavenly Dog | $6,216,067 | 114 | $323,320 | 114 | Jul 11, 1980 | Twentieth Century Fox |
| 57 | Top Dog | $5,093,707 | 1,911 | $2,164,381 | 1,911 | Apr 28, 1995 | Metro-Goldwyn-Mayer (MGM) |
| 58 | Fluke | $3,987,768 | 1,200 | $1,435,709 | 1,200 | Jun 2, 1995 | Metro-Goldwyn-Mayer (MGM) |
| 59 | Benji: Off the Leash! | $3,817,362 | 877 | $1,512,000 | 877 | Aug 20, 2004 | - |
| 60 | Scoob! | $2,188,425 | - | $850,000 | 2,500 | May 21, 2021 | Warner Bros. |
| 61 | A Dog of Flanders | $2,165,637 | 1,267 | $807,873 | 1,267 | Aug 27, 1999 | Warner Bros. |
| 62 | The Stray | $1,579,440 | 640 | $596,547 | 640 | Oct 6, 2017 | Purdie Distribution |
| 63 | Shiloh | $1,007,822 | 70 | $115,710 | 70 | Apr 25, 1997 | - |
| 64 | Watchers | $940,173 | 161 | $260,820 | 161 | Dec 2, 1988 | Universal Pictures |
| 65 | Darling Companion | $793,815 | 64 | $39,962 | 4 | Apr 20, 2012 | Sony Pictures Classics |
| 66 | Lassie | $652,163 | 169 | $254,420 | 169 | Sep 1, 2006 | IDP Distribution |
| 67 | Pick of the Litter | $578,717 | 60 | $16,519 | 2 | Aug 31, 2018 | IFC Films |
| 68 | Shiloh 2: Shiloh Season | $58,946 | 35 | $2,765 | 8 | Jun 25, 1999 | - |
| 69 | White Dog | $46,509 | - | - | - | Nov 12, 1982 | Paramount Pictures |
| 70 | Wrong | $46,021 | 20 | $20,424 | 16 | Mar 29, 2013 | Drafthouse Films |
| 71 | Bailey's Billion$ | $45,000 | 37 | $45,000 | 37 | Aug 5, 2005 | Echo Bridge Entertainment |
| 72 | The Dog Wedding | $29,495 | 2 | $12,132 | 1 | Mar 11, 2016 | 25th Frame |
| 73 | We Think the World of You | $20,998 | 1 | $5,465 | 1 | Dec 22, 1988 | Cinecom Pictures |
| 74 | Quill: The Life of a Guide Dog | $15,674 | 5 | $1,678 | 2 | May 18, 2012 | Music Box Films |
| 75 | The Dog Problem | $1,344 | 2 | $914 | 2 | Apr 27, 2007 | THINKFilm |
