| Rank
| Title
| Lifetime Gross | Max Theaters | Opening | Open Th | Release Date | Distributor
|
|---|
| 1 | Mrs. Doubtfire | $219,195,243 | 2,354 | $20,468,847 | 1,605 | Nov 24, 1993 | Twentieth Century Fox |
| 2 | Tootsie | $177,200,000 | 1,222 | $5,540,470 | 943 | Dec 17, 1982 | Columbia Pictures |
| 3 | The Birdcage | $124,060,553 | 2,285 | $18,275,828 | 1,950 | Mar 8, 1996 | Metro-Goldwyn-Mayer (MGM) |
| 4 | Big Momma's House | $117,559,438 | 2,854 | $25,661,041 | 2,802 | Jun 2, 2000 | Twentieth Century Fox |
| 5 | White Chicks | $70,831,760 | 2,800 | $19,676,748 | 2,726 | Jun 23, 2004 | Sony Pictures Releasing |
| 6 | Big Momma's House 2 | $70,165,972 | 3,261 | $27,736,056 | 3,261 | Jan 27, 2006 | Twentieth Century Fox |
| 7 | Yentl | $40,218,899 | 747 | - | - | Nov 18, 1983 | Metro-Goldwyn-Mayer (MGM) |
| 8 | Big Mommas: Like Father, Like Son | $37,915,414 | 2,821 | $16,300,803 | 2,821 | Feb 18, 2011 | Twentieth Century Fox |
| 9 | To Wong Foo, Thanks for Everything! Julie Newmar | $36,474,193 | 1,489 | $9,019,180 | 1,294 | Sep 8, 1995 | Universal Pictures |
| 10 | She's the Man | $33,741,133 | 2,631 | $10,730,372 | 2,623 | Mar 17, 2006 | DreamWorks |
| 11 | Victor/Victoria | $28,215,453 | 615 | $139,634 | 3 | Mar 19, 1982 | Metro-Goldwyn-Mayer (MGM) |
| 12 | Switch | $15,545,943 | 1,013 | $3,770,991 | 1,013 | May 10, 1991 | Warner Bros. |
| 13 | Ladybugs | $14,796,494 | 1,528 | $5,180,414 | 1,528 | Mar 27, 1992 | Paramount Pictures |
| 14 | Juwanna Mann | $13,670,733 | 1,325 | $5,474,270 | 1,325 | Jun 21, 2002 | Warner Bros. |
| 15 | The Associate | $12,844,057 | 1,781 | $4,261,304 | 1,781 | Oct 25, 1996 | Walt Disney Studios Motion Pictures |
| 16 | Boys Don't Cry | $11,540,607 | 365 | $73,720 | 2 | Oct 8, 1999 | - |
| 17 | Just One of the Guys | $11,528,900 | 1,215 | $3,307,171 | 1,215 | Apr 26, 1985 | Columbia Pictures |
| 18 | The Adventures of Priscilla, Queen of the Desert | $11,220,670 | 192 | $219,433 | 7 | Aug 10, 1994 | Gramercy Pictures (I) |
| 19 | The Danish Girl | $11,114,018 | 794 | $187,318 | 4 | Nov 27, 2015 | Focus Features |
| 20 | Nuns on the Run | $10,959,015 | 702 | $658,835 | 76 | Mar 16, 1990 | Twentieth Century Fox |
| 21 | Sorority Boys | $10,200,032 | 1,801 | $4,127,903 | 1,801 | Mar 22, 2002 | Walt Disney Studios Motion Pictures |
| 22 | Transamerica | $9,015,303 | 656 | $46,908 | 2 | Dec 2, 2005 | The Weinstein Company |
| 23 | Connie and Carla | $8,085,771 | 1,016 | $3,254,940 | 1,014 | Apr 16, 2004 | Universal Pictures |
| 24 | Ed Wood | $5,887,457 | 623 | $71,566 | 2 | Sep 30, 1994 | Walt Disney Studios Motion Pictures |
| 25 | Orlando | $5,319,445 | 78 | $107,030 | 3 | Jun 9, 1993 | Sony Pictures Classics |
| 26 | Flawless | $4,488,529 | 483 | $1,590,155 | 478 | Nov 26, 1999 | Metro-Goldwyn-Mayer (MGM) |
| 27 | Hedwig and the Angry Inch | $3,067,312 | 101 | $156,724 | 9 | Jul 20, 2001 | Fine Line Features |
| 28 | Albert Nobbs | $3,014,696 | 245 | $696,088 | 245 | Jan 27, 2012 | Roadside Attractions |
| 29 | Dr. Jekyll and Ms. Hyde | $2,763,020 | 514 | $900,782 | 350 | Aug 25, 1995 | - |
| 30 | Ma vie en rose | $2,162,043 | 63 | $76,212 | 14 | Dec 26, 1997 | Sony Pictures Classics |
| 31 | Kinky Boots | $1,822,428 | 127 | $77,529 | 9 | Apr 14, 2006 | Miramax |
| 32 | M. Butterfly | $1,498,795 | 120 | $57,280 | 3 | Oct 1, 1993 | Warner Bros. |
| 33 | Breakfast on Pluto | $828,699 | 125 | $33,279 | 3 | Nov 16, 2005 | Sony Pictures Classics |
| 34 | The Ballad of Little Jo | $543,091 | 40 | $20,773 | 3 | Aug 20, 1993 | Fine Line Features |
| 35 | The Triumph of Love | $447,267 | 51 | $60,507 | 18 | Apr 17, 2002 | Paramount Classics |
| 36 | Masti | $308,566 | 29 | $162,687 | 27 | Apr 9, 2004 | Eros Worldwide |
| 37 | Different for Girls | $300,645 | 16 | $52,816 | 14 | Sep 12, 1997 | First Look International |
| 38 | Wasabi Tuna | $51,036 | 5 | $19,080 | 5 | Oct 28, 2005 | Indican Pictures |
| 39 | All the Queen's Men | $23,662 | 17 | $15,026 | 17 | Oct 25, 2002 | Strand Releasing |
| 40 | Cut Sleeve Boys | $13,875 | 4 | $1,982 | 1 | Aug 10, 2007 | Regent Releasing |
