| Rank
| Title
| Lifetime Gross | Max Theaters | Opening | Open Th | Release Date | Distributor
|
|---|
| 1 | Avatar | $749,766,139 | 3,461 | $77,025,481 | 3,452 | Dec 18, 2009 | Twentieth Century Fox |
| 2 | The Bourne Ultimatum | $227,471,070 | 3,701 | $69,283,690 | 3,660 | Aug 3, 2007 | Universal Pictures |
| 3 | The Bourne Supremacy | $176,241,941 | 3,304 | $52,521,865 | 3,165 | Jul 23, 2004 | Universal Pictures |
| 4 | The Vow | $125,014,030 | 3,038 | $41,202,458 | 2,958 | Feb 10, 2012 | Screen Gems |
| 5 | The Bourne Identity | $121,661,683 | 2,663 | $27,118,640 | 2,638 | Jun 14, 2002 | Universal Pictures |
| 6 | 50 First Dates | $120,908,074 | 3,612 | $39,852,237 | 3,591 | Feb 13, 2004 | Sony Pictures Releasing |
| 7 | Total Recall | $119,394,840 | 2,131 | $25,533,700 | 2,060 | Jun 1, 1990 | Sony Pictures Releasing |
| 8 | Million Dollar Baby | $100,492,203 | 2,375 | $179,953 | 8 | Dec 15, 2004 | Warner Bros. |
| 9 | The Notebook | $81,001,787 | 2,323 | $13,464,745 | 2,303 | Jun 25, 2004 | New Line Cinema |
| 10 | Born on the Fourth of July | $70,001,698 | 1,434 | $172,021 | 5 | Dec 22, 1989 | Universal Pictures |
| 11 | The Forgotten | $67,133,509 | 3,144 | $21,022,111 | 3,104 | Sep 24, 2004 | Revolution Studios |
| 12 | The Bone Collector | $66,518,655 | 2,623 | $16,712,020 | 2,587 | Nov 5, 1999 | Universal Pictures |
| 13 | Unknown | $63,686,397 | 3,043 | $21,856,389 | 3,043 | Feb 18, 2011 | Warner Bros. |
| 14 | Gothika | $59,694,580 | 2,382 | $19,288,438 | 2,382 | Nov 21, 2003 | Warner Bros. |
| 15 | Total Recall | $58,877,969 | 3,601 | $25,577,758 | 3,601 | Aug 3, 2012 | Sony Pictures Releasing |
| 16 | Anastasia | $58,406,347 | 2,511 | $120,541 | 1 | Nov 14, 1997 | Twentieth Century Fox |
| 17 | Paycheck | $53,790,451 | 2,762 | $13,462,374 | 2,762 | Dec 25, 2003 | Paramount Pictures |
| 18 | Regarding Henry | $43,001,500 | 1,090 | $6,146,782 | 800 | Jul 12, 1991 | Paramount Pictures |
| 19 | Dead Again | $38,016,380 | 940 | $3,479,395 | 450 | Aug 23, 1991 | Paramount Pictures |
| 20 | The Theory of Everything | $35,893,537 | 1,220 | $208,763 | 5 | Nov 7, 2014 | Focus Features |
| 21 | Eternal Sunshine of the Spotless Mind | $34,400,301 | 1,357 | $8,175,198 | 1,353 | Mar 19, 2004 | Focus Features |
| 22 | The Long Kiss Goodnight | $33,447,612 | 2,404 | $9,065,363 | 2,245 | Oct 11, 1996 | New Line Cinema |
| 23 | Coming Home | $32,653,905 | - | - | - | Feb 15, 1978 | United Artists |
| 24 | The Majestic | $27,807,266 | 2,361 | $4,904,339 | 2,361 | Dec 21, 2001 | Warner Bros. |
| 25 | Desperately Seeking Susan | $27,398,584 | 1,108 | $1,526,098 | 268 | Mar 29, 1985 | Orion Pictures |
| 26 | Overboard | $26,713,187 | 1,135 | $1,880,006 | 1,126 | Dec 18, 1987 | Metro-Goldwyn-Mayer (MGM) |
| 27 | Memento | $25,544,867 | 531 | $235,488 | 11 | Mar 16, 2001 | Newmarket Films |
| 28 | Angel Eyes | $24,174,218 | 2,407 | $9,225,575 | 2,375 | May 18, 2001 | Warner Bros. |
| 29 | Dream House | $21,302,340 | 2,664 | $8,129,355 | 2,661 | Sep 30, 2011 | Universal Pictures |
| 30 | Extreme Measures | $17,380,126 | 2,298 | $6,906,546 | 2,298 | Sep 27, 1996 | Sony Pictures Releasing |
| 31 | My Left Foot | $14,743,391 | 510 | $41,165 | 2 | Nov 10, 1989 | Miramax |
| 32 | Dark City | $14,378,331 | 1,754 | $5,576,953 | 1,754 | Feb 27, 1998 | New Line Cinema |
| 33 | Gattaca | $12,532,777 | 1,279 | $4,320,202 | 1,279 | Oct 24, 1997 | Sony Pictures Releasing |
| 34 | The Other Side of the Mountain: Part II | $11,565,678 | - | - | - | Jan 1, 1978 | Universal Pictures |
| 35 | The Intouchables | $10,198,820 | 194 | $103,507 | 4 | May 25, 2012 | The Weinstein Company |
| 36 | Whose Life Is It Anyway? | $8,206,145 | 615 | - | - | Dec 2, 1981 | Metro-Goldwyn-Mayer (MGM) |
| 37 | Clean Slate | $7,355,425 | 1,474 | $3,136,130 | 1,457 | May 6, 1994 | Metro-Goldwyn-Mayer (MGM) |
| 38 | Mulholland Drive | $7,220,243 | 247 | $587,591 | 66 | Oct 8, 2001 | Universal Pictures |
| 39 | Mac and Me | $6,424,112 | 1,317 | $2,061,464 | 1,314 | Aug 12, 1988 | Orion Pictures |
| 40 | The Sessions | $6,002,451 | 516 | $113,467 | 4 | Oct 19, 2012 | - |
| 41 | Monkey Shines | $5,344,577 | 1,181 | $1,902,024 | 1,181 | Jul 29, 1988 | Orion Pictures |
| 42 | Passion Fish | $4,814,619 | 191 | $14,385 | 2 | Dec 9, 1992 | Miramax |
| 43 | Resurrection | $3,910,019 | 417 | $308,068 | 417 | Sep 26, 1980 | Universal Pictures |
| 44 | The Sea Inside | $2,104,923 | 99 | $55,681 | 23 | Dec 17, 2004 | Fine Line Features |
| 45 | Rust and Bone | $2,062,027 | 168 | $27,154 | 2 | Nov 23, 2012 | Sony Pictures Classics |
| 46 | The Waterdance | $1,723,319 | 60 | $138,313 | 33 | May 15, 1992 | The Samuel Goldwyn Company |
| 47 | Murderball | $1,531,154 | 97 | $57,286 | 8 | Jul 8, 2005 | THINKFilm |
| 48 | Don't Worry, He Won't Get Far on Foot | $1,441,705 | 266 | $83,339 | 4 | Jul 13, 2018 | Amazon Studios |
| 49 | Amateur | $757,088 | - | - | - | May 19, 1995 | Sony Pictures Classics |
| 50 | Breathe | $490,131 | 315 | $22,285 | 4 | Oct 13, 2017 | Bleecker Street Media |
| 51 | War Eagle, Arkansas | $123,670 | 7 | $16,467 | 7 | Jun 12, 2009 | Hannover House |
| 52 | Rory O'Shea Was Here | $23,844 | 7 | $6,079 | 3 | Feb 4, 2005 | Focus Features |
| 53 | Diminished Capacity | $21,659 | 4 | $11,832 | 4 | Jul 4, 2008 | IFC Films |
| 54 | Quid Pro Quo | $11,864 | 4 | $7,395 | 4 | Jun 13, 2008 | Magnolia Pictures |
| 55 | Oasis | $10,304 | 2 | $6,485 | 2 | May 7, 2004 | - |
| 56 | Apart | $3,161 | 2 | $3,161 | 2 | Mar 9, 2012 | Truly Indie |
