| Rank
| Title
| Lifetime Gross | Max Theaters | Opening | Open Th | Release Date | Distributor
|
|---|
| 501 | Love, Simon | $40,826,341 | 2,434 | $11,756,244 | 2,402 | Mar 16, 2018 | Twentieth Century Fox |
| 502 | Max Payne | $40,689,393 | 3,381 | $17,639,849 | 3,376 | Oct 17, 2008 | Twentieth Century Fox |
| 503 | Three Fugitives | $40,586,886 | 1,374 | $6,434,717 | 1,153 | Jan 27, 1989 | Walt Disney Studios Motion Pictures |
| 504 | Ghost in the Shell | $40,563,557 | 3,440 | $18,676,033 | 3,440 | Mar 31, 2017 | Paramount Pictures |
| 505 | Peter Rabbit 2: The Runaway | $40,501,717 | 3,346 | $10,101,066 | 3,346 | Jun 11, 2021 | Sony Pictures Releasing |
| 506 | The Fly | $40,456,565 | 1,201 | $7,007,423 | 1,195 | Aug 15, 1986 | Twentieth Century Fox |
| 507 | 2010: The Year We Make Contact | $40,400,657 | 1,213 | $7,393,361 | 1,126 | Dec 7, 1984 | Metro-Goldwyn-Mayer (MGM) |
| 508 | Catwoman | $40,202,379 | 3,117 | $16,728,411 | 3,117 | Jul 23, 2004 | Warner Bros. |
| 509 | Resident Evil | $40,119,709 | 2,528 | $17,707,106 | 2,528 | Mar 15, 2002 | Screen Gems |
| 510 | The Wild Thornberrys | $40,108,697 | 3,012 | $6,013,847 | 3,012 | Dec 20, 2002 | Paramount Pictures |
| 511 | The Ladykillers | $39,799,191 | 1,589 | $12,634,563 | 1,583 | Mar 26, 2004 | Walt Disney Studios Motion Pictures |
| 512 | Hitman | $39,687,694 | 2,468 | $13,180,769 | 2,458 | Nov 21, 2007 | Twentieth Century Fox |
| 513 | 30 Days of Night | $39,569,000 | 2,859 | $15,951,902 | 2,855 | Oct 19, 2007 | Sony Pictures Releasing |
| 514 | The Texas Chainsaw Massacre: The Beginning | $39,517,763 | 2,820 | $19,150,000 | 2,820 | Oct 6, 2006 | New Line Cinema |
| 515 | Rugrats Go Wild | $39,402,572 | 3,041 | $11,556,869 | 3,041 | Jun 13, 2003 | Paramount Pictures |
| 516 | The Grudge 2 | $39,143,839 | 3,214 | $20,825,300 | 3,211 | Oct 13, 2006 | Sony Pictures Releasing |
| 517 | The Crazies | $39,123,589 | 2,479 | $16,067,552 | 2,476 | Feb 26, 2010 | Overture Films |
| 518 | The Sisterhood of the Traveling Pants | $39,053,061 | 2,583 | $9,833,340 | 2,583 | Jun 1, 2005 | Warner Bros. |
| 519 | Primary Colors | $39,001,187 | 1,976 | $12,045,395 | 1,965 | Mar 20, 1998 | Universal Pictures |
| 520 | The Ghost and the Darkness | $38,619,405 | 2,202 | $9,215,063 | 2,142 | Oct 11, 1996 | Paramount Pictures |
| 521 | Surrogates | $38,577,772 | 2,992 | $14,902,692 | 2,951 | Sep 25, 2009 | Walt Disney Studios Motion Pictures |
| 522 | Last Holiday | $38,399,961 | 2,514 | $12,806,188 | 2,514 | Jan 13, 2006 | Paramount Pictures |
| 523 | Mighty Morphin Power Rangers | $38,187,431 | 2,409 | $13,104,788 | 2,409 | Jun 30, 1995 | Twentieth Century Fox |
| 524 | The Running Man | $38,122,105 | 1,694 | $8,117,465 | 1,692 | Nov 13, 1987 | TriStar Pictures |
| 525 | Richie Rich | $38,087,756 | 1,761 | $5,830,302 | 1,748 | Dec 21, 1994 | Warner Bros. |
| 526 | Bedazzled | $37,886,980 | 2,571 | $13,106,526 | 2,568 | Oct 20, 2000 | Twentieth Century Fox |
| 527 | The King's Man | $37,176,373 | 3,180 | $5,915,542 | 3,180 | Dec 22, 2021 | 20th Century Studios |
| 528 | Sphere | $37,020,277 | 2,814 | $14,433,957 | 2,814 | Feb 13, 1998 | Warner Bros. |
| 529 | My Favorite Martian | $36,850,101 | 2,349 | $8,828,586 | 2,275 | Feb 12, 1999 | Walt Disney Studios Motion Pictures |
| 530 | The Heartbreak Kid | $36,787,257 | 3,233 | $14,022,105 | 3,229 | Oct 5, 2007 | DreamWorks |
| 531 | Recess: School's Out | $36,706,141 | 2,630 | $10,065,873 | 2,624 | Feb 16, 2001 | Walt Disney Studios Motion Pictures |
| 532 | Taxi | $36,611,066 | 3,001 | $12,029,832 | 3,001 | Oct 6, 2004 | Twentieth Century Fox |
| 533 | Death Race | $36,316,032 | 2,586 | $12,621,090 | 2,532 | Aug 22, 2008 | Universal Pictures |
| 534 | What a Girl Wants | $36,105,433 | 2,964 | $11,434,964 | 2,964 | Apr 4, 2003 | Warner Bros. |
| 535 | Mortal Kombat: Annihilation | $35,927,406 | 2,140 | $16,771,694 | 2,140 | Nov 21, 1997 | New Line Cinema |
| 536 | The Pink Panther 2 | $35,922,978 | 3,245 | $11,588,150 | 3,243 | Feb 6, 2009 | Sony Pictures Releasing |
| 537 | The Mothman Prophecies | $35,746,370 | 2,331 | $11,208,851 | 2,331 | Jan 25, 2002 | Screen Gems |
| 538 | The Indian in the Cupboard | $35,656,131 | 1,723 | $7,716,278 | 1,723 | Jul 14, 1995 | Paramount Pictures |
| 539 | Children of Men | $35,552,383 | 1,524 | $501,003 | 16 | Dec 25, 2006 | Universal Pictures |
| 540 | The Hustle | $35,417,038 | 3,077 | $13,007,709 | 3,007 | May 10, 2019 | United Artists Releasing |
| 541 | A Goofy Movie | $35,348,597 | 2,176 | $6,129,557 | 2,159 | Apr 7, 1995 | Walt Disney Studios Motion Pictures |
| 542 | The Flintstones in Viva Rock Vegas | $35,268,275 | 3,125 | $10,518,435 | 3,040 | Apr 28, 2000 | Universal Pictures |
| 543 | Carrie | $35,266,619 | 3,157 | $16,101,552 | 3,157 | Oct 18, 2013 | Screen Gems |
| 544 | The 5th Wave | $34,916,787 | 2,908 | $10,326,356 | 2,908 | Jan 22, 2016 | Sony Pictures Releasing |
| 545 | Judge Dredd | $34,693,481 | 2,204 | $12,291,536 | 2,204 | Jun 30, 1995 | Walt Disney Studios Motion Pictures |
| 546 | Muppet Treasure Island | $34,327,391 | 2,089 | $7,906,689 | 2,070 | Feb 16, 1996 | Walt Disney Studios Motion Pictures |
| 547 | My Dog Skip | $34,134,641 | 2,331 | $56,943 | 5 | Jan 14, 2000 | Warner Bros. |
| 548 | Everything, Everything | $34,121,140 | 2,801 | $11,727,390 | 2,801 | May 19, 2017 | Warner Bros. |
| 549 | Death Wish | $34,017,028 | 2,882 | $13,010,267 | 2,847 | Mar 2, 2018 | Metro-Goldwyn-Mayer (MGM) |
| 550 | Closer | $33,987,757 | 1,098 | $7,707,972 | 476 | Dec 3, 2004 | Sony Pictures Releasing |
| 551 | The Punisher | $33,810,189 | 2,649 | $14,000,000 | 2,649 | Apr 16, 2004 | Lionsgate |
| 552 | Dreamcatcher | $33,715,436 | 2,945 | $15,027,423 | 2,945 | Mar 21, 2003 | Warner Bros. |
| 553 | R.I.P.D. | $33,618,855 | 2,852 | $12,691,415 | 2,852 | Jul 19, 2013 | Universal Pictures |
| 554 | I Spy | $33,561,137 | 3,182 | $12,752,803 | 3,182 | Nov 1, 2002 | Sony Pictures Releasing |
| 555 | Matilda | $33,459,416 | 2,006 | $8,208,609 | 1,975 | Aug 2, 1996 | Sony Pictures Releasing |
| 556 | Street Fighter | $33,423,521 | 1,738 | $6,859,495 | 1,671 | Dec 23, 1994 | Universal Pictures |
| 557 | Halloween II | $33,392,973 | 3,088 | $16,349,565 | 3,025 | Aug 28, 2009 | Dimension Films |
| 558 | Arthur | $33,035,397 | 3,276 | $12,222,756 | 3,276 | Apr 8, 2011 | Warner Bros. |
| 559 | Bad News Bears | $32,868,349 | 3,183 | $11,382,472 | 3,183 | Jul 22, 2005 | Paramount Pictures |
| 560 | Homeward Bound II: Lost in San Francisco | $32,772,492 | 2,129 | $8,605,649 | 2,119 | Mar 8, 1996 | Walt Disney Studios Motion Pictures |
| 561 | The Last House on the Left | $32,752,215 | 2,402 | $14,118,685 | 2,401 | Mar 13, 2009 | Universal Pictures |
| 562 | Annihilation | $32,732,301 | 2,112 | $11,071,584 | 2,012 | Feb 23, 2018 | Paramount Pictures |
| 563 | Because of Winn-Dixie | $32,647,042 | 3,188 | $10,208,431 | 3,188 | Feb 18, 2005 | Twentieth Century Fox |
| 564 | Entourage | $32,363,404 | 3,108 | $10,283,250 | 3,108 | Jun 3, 2015 | Warner Bros. |
| 565 | Final Fantasy: The Spirits Within | $32,131,830 | 2,649 | $11,408,853 | 2,649 | Jul 11, 2001 | Sony Pictures Releasing |
| 566 | House of Wax | $32,064,800 | 3,111 | $12,077,236 | 3,111 | May 6, 2005 | Warner Bros. |
| 567 | The Shadow | $32,063,435 | 1,769 | $11,713,845 | 1,677 | Jul 1, 1994 | Universal Pictures |
| 568 | Paper Towns | $32,000,304 | 3,031 | $12,650,140 | 3,031 | Jul 24, 2015 | Twentieth Century Fox |
| 569 | Quarantine | $31,691,811 | 2,463 | $14,211,321 | 2,461 | Oct 10, 2008 | Screen Gems |
| 570 | Scott Pilgrim vs. the World | $31,657,980 | 2,820 | $10,609,795 | 2,818 | Aug 13, 2010 | Universal Pictures |
| 571 | From Hell | $31,602,566 | 2,334 | $11,014,818 | 2,305 | Oct 19, 2001 | Twentieth Century Fox |
| 572 | A History of Violence | $31,504,633 | 1,348 | $364,000 | 14 | Sep 23, 2005 | New Line Cinema |
| 573 | Dune | $31,439,560 | 975 | $6,025,091 | 915 | Dec 14, 1984 | Universal Pictures |
| 574 | The Eye | $31,418,697 | 2,470 | $12,425,776 | 2,436 | Feb 1, 2008 | Lionsgate |
| 575 | The Great Muppet Caper | $31,206,251 | 73 | $2,968,990 | 73 | Jun 26, 1981 | Universal Pictures |
| 576 | The Secret Garden | $31,181,347 | 1,332 | $4,625,583 | 1,319 | Aug 13, 1993 | Warner Bros. |
| 577 | The Mortal Instruments: City of Bones | $31,165,421 | 3,118 | $9,336,957 | 3,118 | Aug 21, 2013 | Screen Gems |
| 578 | The Princess Bride | $30,857,814 | 803 | $206,243 | 9 | Sep 25, 1987 | Twentieth Century Fox |
| 579 | Mirrors | $30,691,439 | 2,664 | $11,161,074 | 2,664 | Aug 15, 2008 | Twentieth Century Fox |
| 580 | Sgt. Bilko | $30,356,793 | 2,326 | $8,110,080 | 2,304 | Mar 29, 1996 | Universal Pictures |
| 581 | Point of No Return | $30,038,362 | 1,659 | $7,160,389 | 1,545 | Mar 19, 1993 | Warner Bros. |
| 582 | Madeline | $29,967,750 | 1,863 | $6,414,668 | 1,863 | Jul 10, 1998 | Sony Pictures Releasing |
| 583 | Teen Titans GO! To the Movies | $29,790,236 | 3,188 | $10,411,189 | 3,188 | Jul 27, 2018 | Warner Bros. |
| 584 | Mystery Men | $29,762,011 | 2,142 | $10,017,865 | 2,136 | Aug 6, 1999 | Universal Pictures |
| 585 | The Hate U Give | $29,719,483 | 2,375 | $512,035 | 36 | Oct 5, 2018 | Twentieth Century Fox |
| 586 | The Fog | $29,550,869 | 2,972 | $11,752,917 | 2,972 | Oct 14, 2005 | Revolution Studios |
| 587 | Twilight Zone: The Movie | $29,450,919 | 1,288 | $6,614,366 | 1,275 | Jun 24, 1983 | Warner Bros. |
| 588 | Major Payne | $29,412,050 | 1,991 | $7,011,225 | 1,895 | Mar 24, 1995 | Universal Pictures |
| 589 | Zathura: A Space Adventure | $29,258,869 | 3,232 | $13,427,872 | 3,223 | Nov 11, 2005 | Sony Pictures Releasing |
| 590 | Romy and Michele's High School Reunion | $29,235,353 | 1,607 | $7,429,406 | 1,602 | Apr 25, 1997 | Walt Disney Studios Motion Pictures |
| 591 | Priest | $29,137,000 | 2,864 | $14,953,664 | 2,864 | May 13, 2011 | Screen Gems |
| 592 | The Mechanic | $29,121,498 | 2,704 | $11,422,006 | 2,703 | Jan 28, 2011 | CBS Films |
| 593 | The Stepfather | $29,062,561 | 2,734 | $11,581,586 | 2,734 | Oct 16, 2009 | Screen Gems |
| 594 | James and the Giant Peach | $28,946,127 | 2,268 | $7,539,098 | 2,262 | Apr 12, 1996 | Walt Disney Studios Motion Pictures |
| 595 | Kick-Ass 2 | $28,795,985 | 2,945 | $13,332,955 | 2,940 | Aug 16, 2013 | Universal Pictures |
| 596 | Point Break | $28,782,481 | 2,910 | $9,800,252 | 2,910 | Dec 25, 2015 | Warner Bros. |
| 597 | Fathers' Day | $28,598,376 | 2,507 | $8,776,159 | 2,482 | May 9, 1997 | Warner Bros. |
| 598 | The Uninvited | $28,596,818 | 2,344 | $10,325,824 | 2,344 | Jan 30, 2009 | DreamWorks |
| 599 | The Out-of-Towners | $28,544,120 | 2,128 | $8,224,215 | 2,102 | Apr 2, 1999 | Paramount Pictures |
| 600 | Garfield: A Tail of Two Kitties | $28,426,747 | 2,981 | $7,288,977 | 2,946 | Jun 16, 2006 | Twentieth Century Fox |
