| Rank
| Release
| Opening
| Total Gross
| % of Total
| Theaters
| Average
| Date
| Distributor
|
|---|
| 201 | Clash of the Titans | $61,235,105 | $163,214,888 | 37.5% | 3,777 | $16,212 | Apr 2, 2010 | Warner Bros. |
| 202 | Transformers: Rise of the Beasts | $61,045,464 | $157,066,392 | 38.9% | 3,678 | $16,597 | Jun 9, 2023 | Paramount Pictures |
| 203 | Kong: Skull Island | $61,025,472 | $168,052,812 | 36.3% | 3,846 | $15,867 | Mar 10, 2017 | Warner Bros. |
| 204 | Indiana Jones and the Dial of Destiny | $60,368,101 | $174,480,468 | 34.6% | 4,600 | $13,123 | Jun 30, 2023 | Walt Disney Studios Motion Pictures |
| 205 | Madagascar 3: Europe's Most Wanted | $60,316,738 | $216,391,482 | 27.9% | 4,258 | $14,165 | Jun 8, 2012 | DreamWorks |
| 206 | Kung Fu Panda | $60,239,130 | $215,434,591 | 28% | 4,114 | $14,642 | Jun 6, 2008 | DreamWorks |
| 207 | Straight Outta Compton | $60,200,180 | $161,197,785 | 37.4% | 2,757 | $21,835 | Aug 14, 2015 | Universal Pictures |
| 208 | Cars | $60,119,509 | $244,082,982 | 24.6% | 3,985 | $15,086 | Jun 9, 2006 | Walt Disney Studios Motion Pictures |
| 209 | Signs | $60,117,080 | $227,966,634 | 26.4% | 3,264 | $18,418 | Aug 2, 2002 | Walt Disney Studios Motion Pictures |
| 210 | Fast & Furious Presents: Hobbs & Shaw | $60,038,950 | $173,956,935 | 34.5% | 4,253 | $14,116 | Aug 2, 2019 | Universal Pictures |
| 211 | Monsters vs. Aliens | $59,321,095 | $198,351,526 | 29.9% | 4,104 | $14,454 | Mar 27, 2009 | DreamWorks |
| 212 | Star Trek Beyond | $59,253,211 | $158,848,340 | 37.3% | 3,928 | $15,084 | Jul 22, 2016 | Paramount Pictures |
| 213 | Jumanji: The Next Level | $59,251,543 | $320,314,960 | 18.5% | 4,227 | $14,017 | Dec 13, 2019 | Sony Pictures Releasing |
| 214 | Jason Bourne | $59,215,365 | $162,434,410 | 36.4% | 4,026 | $14,708 | Jul 29, 2016 | Universal Pictures |
| 215 | Pearl Harbor | $59,078,912 | $198,542,554 | 29.8% | 3,214 | $18,381 | May 25, 2001 | Walt Disney Studios Motion Pictures |
| 216 | Kingdom of the Planet of the Apes | $58,400,788 | $171,130,165 | 34.1% | 4,075 | $14,331 | May 10, 2024 | 20th Century Studios |
| 217 | Creed III | $58,370,007 | $156,248,615 | 37.4% | 4,007 | $14,567 | Mar 3, 2023 | United Artists Releasing |
| 218 | Fantastic Four: Rise of the Silver Surfer | $58,051,684 | $131,921,738 | 44% | 3,959 | $14,663 | Jun 15, 2007 | Twentieth Century Fox |
| 219 | Sonic the Hedgehog | $58,018,348 | $148,974,665 | 39% | 4,167 | $13,923 | Feb 14, 2020 | Paramount Pictures |
| 220 | Hannibal | $58,003,121 | $165,092,268 | 35.1% | 3,230 | $17,957 | Feb 9, 2001 | Metro-Goldwyn-Mayer (MGM) |
| 221 | Kung Fu Panda 4 | $57,989,905 | $193,590,620 | 30% | 4,035 | $14,371 | Mar 8, 2024 | Universal Pictures |
| 222 | Mission: Impossible II | $57,845,297 | $215,409,889 | 26.8% | 3,653 | $15,835 | May 24, 2000 | Paramount Pictures |
| 223 | Ant-Man | $57,225,526 | $180,202,163 | 31.8% | 3,856 | $14,840 | Jul 17, 2015 | Walt Disney Studios Motion Pictures |
| 224 | 22 Jump Street | $57,071,445 | $191,719,337 | 29.8% | 3,306 | $17,262 | Jun 13, 2014 | Sony Pictures Releasing |
| 225 | Sex and the City | $57,038,404 | $152,647,258 | 37.4% | 3,285 | $17,363 | May 30, 2008 | Warner Bros. |
| 226 | John Wick: Chapter 3 - Parabellum | $56,818,067 | $171,015,687 | 33.2% | 3,850 | $14,757 | May 17, 2019 | Lionsgate |
| 227 | Moana | $56,631,401 | $248,757,044 | 22.8% | 3,875 | $14,614 | Nov 23, 2016 | Walt Disney Studios Motion Pictures |
| 228 | Bad Boys: Ride or Die | $56,527,324 | $193,573,217 | 29.2% | 3,885 | $14,550 | Jun 7, 2024 | Sony Pictures Releasing |
| 229 | Despicable Me | $56,397,125 | $251,639,815 | 22.4% | 3,476 | $16,224 | Jul 9, 2010 | Universal Pictures |
| 230 | War for the Planet of the Apes | $56,262,929 | $146,880,162 | 38.3% | 4,022 | $13,988 | Jul 14, 2017 | Twentieth Century Fox |
| 231 | Valentine's Day | $56,260,707 | $110,485,654 | 50.9% | 3,665 | $15,350 | Feb 12, 2010 | Warner Bros. |
| 232 | Ralph Breaks the Internet | $56,237,634 | $201,091,711 | 28% | 4,017 | $13,999 | Nov 21, 2018 | Walt Disney Studios Motion Pictures |
| 233 | Snow White and the Huntsman | $56,217,700 | $155,332,381 | 36.2% | 3,773 | $14,900 | Jun 1, 2012 | Universal Pictures |
| 234 | Big Hero 6 | $56,215,889 | $222,527,828 | 25.3% | 3,761 | $14,947 | Nov 7, 2014 | Walt Disney Studios Motion Pictures |
| 235 | Charlie and the Chocolate Factory | $56,178,450 | $206,459,076 | 27.2% | 3,770 | $14,901 | Jul 15, 2005 | Warner Bros. |
| 236 | Fantastic Four | $56,061,504 | $154,696,080 | 36.2% | 3,602 | $15,563 | Jul 8, 2005 | Twentieth Century Fox |
| 237 | Gravity | $55,785,112 | $274,092,705 | 20.4% | 3,575 | $15,604 | Oct 4, 2013 | Warner Bros. |
| 238 | The Karate Kid | $55,665,805 | $176,591,618 | 31.5% | 3,663 | $15,196 | Jun 11, 2010 | Sony Pictures Releasing |
| 239 | Mission: Impossible - Rogue Nation | $55,520,089 | $195,042,377 | 28.5% | 3,956 | $14,034 | Jul 31, 2015 | Paramount Pictures |
| 240 | The Incredible Hulk | $55,414,050 | $134,806,913 | 41.1% | 3,505 | $15,810 | Jun 13, 2008 | Universal Pictures |
| 241 | The SpongeBob Movie: Sponge Out of Water | $55,365,012 | $162,994,032 | 34% | 3,641 | $15,205 | Feb 6, 2015 | Paramount Pictures |
| 242 | No Time to Die | $55,225,007 | $160,891,007 | 34.3% | 4,407 | $12,531 | Oct 8, 2021 | Metro-Goldwyn-Mayer (MGM) |
| 243 | Watchmen | $55,214,334 | $107,509,799 | 51.4% | 3,611 | $15,290 | Mar 6, 2009 | Warner Bros. |
| 244 | X-Men: First Class | $55,101,604 | $146,408,305 | 37.6% | 3,641 | $15,133 | Jun 3, 2011 | Twentieth Century Fox |
| 245 | How the Grinch Stole Christmas | $55,082,330 | $260,745,620 | 21.1% | 3,127 | $17,615 | Nov 17, 2000 | Universal Pictures |
| 246 | The Flash | $55,043,679 | $108,133,313 | 50.9% | 4,234 | $13,000 | Jun 16, 2023 | Warner Bros. |
| 247 | The Chronicles of Narnia: Prince Caspian | $55,034,805 | $141,621,490 | 38.9% | 3,929 | $14,007 | May 16, 2008 | Walt Disney Studios Motion Pictures |
| 248 | How to Train Your Dragon: The Hidden World | $55,022,245 | $160,799,505 | 34.2% | 4,259 | $12,919 | Feb 22, 2019 | Universal Pictures |
| 249 | Austin Powers: The Spy Who Shagged Me | $54,917,604 | $206,040,086 | 26.6% | 3,312 | $16,581 | Jun 9, 1999 | New Line Cinema |
| 250 | Rise of the Planet of the Apes | $54,806,191 | $176,760,185 | 31% | 3,648 | $15,023 | Aug 5, 2011 | Twentieth Century Fox |
| 251 | The Hobbit: The Battle of the Five Armies | $54,724,334 | $255,119,788 | 21.4% | 3,875 | $14,122 | Dec 17, 2014 | Warner Bros. |
| 252 | G.I. Joe: The Rise of Cobra | $54,713,046 | $150,201,498 | 36.4% | 4,007 | $13,654 | Aug 7, 2009 | Paramount Pictures |
| 253 | Mission: Impossible - Dead Reckoning Part One | $54,688,347 | $172,135,383 | 31.8% | 4,327 | $12,638 | Jul 12, 2023 | Paramount Pictures |
| 254 | Divergent | $54,607,747 | $150,947,895 | 36.2% | 3,936 | $13,873 | Mar 21, 2014 | Lionsgate |
| 255 | Men in Black³ | $54,592,779 | $179,020,854 | 30.5% | 4,248 | $12,851 | May 25, 2012 | Sony Pictures Releasing |
| 256 | San Andreas | $54,588,173 | $155,190,832 | 35.2% | 3,777 | $14,452 | May 29, 2015 | Warner Bros. |
| 257 | X-Men | $54,471,475 | $157,299,718 | 34.6% | 3,025 | $18,007 | Jul 14, 2000 | Twentieth Century Fox |
| 258 | Ted | $54,415,205 | $218,815,487 | 24.9% | 3,239 | $16,800 | Jun 29, 2012 | Universal Pictures |
| 259 | Pokémon: Detective Pikachu | $54,365,242 | $144,105,346 | 37.7% | 4,202 | $12,937 | May 10, 2019 | Warner Bros. |
| 260 | The Martian | $54,308,575 | $228,433,663 | 23.8% | 3,831 | $14,176 | Oct 2, 2015 | Twentieth Century Fox |
| 261 | Night at the Museum: Battle of the Smithsonian | $54,173,286 | $177,243,721 | 30.6% | 4,096 | $13,225 | May 22, 2009 | Twentieth Century Fox |
| 262 | Scooby-Doo | $54,155,312 | $153,294,164 | 35.3% | 3,447 | $15,710 | Jun 14, 2002 | Warner Bros. |
| 263 | The Nun | $53,807,379 | $117,450,119 | 45.8% | 3,876 | $13,882 | Sep 7, 2018 | Warner Bros. |
| 264 | Cars 3 | $53,688,680 | $152,901,115 | 35.1% | 4,256 | $12,614 | Jun 16, 2017 | Walt Disney Studios Motion Pictures |
| 265 | Shazam! | $53,505,326 | $140,371,656 | 38.1% | 4,217 | $12,688 | Apr 5, 2019 | Warner Bros. |
| 266 | Green Lantern | $53,174,303 | $116,601,172 | 45.6% | 3,816 | $13,934 | Jun 17, 2011 | Warner Bros. |
| 267 | The Wolverine | $53,113,752 | $132,556,852 | 40.1% | 3,924 | $13,535 | Jul 26, 2013 | Twentieth Century Fox |
| 268 | The Lego Batman Movie | $53,003,468 | $175,750,384 | 30.2% | 4,088 | $12,965 | Feb 10, 2017 | Warner Bros. |
| 269 | Batman Forever | $52,784,433 | $184,031,112 | 28.7% | 2,842 | $18,572 | Jun 16, 1995 | Warner Bros. |
| 270 | Paranormal Activity 3 | $52,568,183 | $104,028,807 | 50.5% | 3,321 | $15,829 | Oct 21, 2011 | Paramount Pictures |
| 271 | Superman Returns | $52,535,096 | $200,081,192 | 26.3% | 4,065 | $12,923 | Jun 28, 2006 | Warner Bros. |
| 272 | The Bourne Supremacy | $52,521,865 | $176,241,941 | 29.8% | 3,165 | $16,594 | Jul 23, 2004 | Universal Pictures |
| 273 | The Divergent Series: Insurgent | $52,263,680 | $130,179,072 | 40.2% | 3,875 | $13,487 | Mar 20, 2015 | Lionsgate |
| 274 | A Quiet Place: Day One | $52,202,495 | $138,930,553 | 37.6% | 3,707 | $14,082 | Jun 28, 2024 | Paramount Pictures |
| 275 | I, Robot | $52,179,887 | $144,801,023 | 36% | 3,420 | $15,257 | Jul 16, 2004 | Twentieth Century Fox |
| 276 | Men in Black II | $52,148,751 | $190,418,803 | 27.4% | 3,557 | $14,660 | Jul 3, 2002 | Sony Pictures Releasing |
| 277 | Home | $52,107,731 | $177,397,510 | 29.4% | 3,708 | $14,052 | Mar 27, 2015 | Twentieth Century Fox |
| 278 | Van Helsing | $51,748,040 | $120,177,084 | 43.1% | 3,575 | $14,474 | May 7, 2004 | Universal Pictures |
| 279 | 8 Mile | $51,240,555 | $116,750,901 | 43.9% | 2,470 | $20,745 | Nov 8, 2002 | Universal Pictures |
| 280 | Men in Black | $51,068,455 | $250,690,539 | 20.4% | 3,020 | $16,910 | Jul 2, 1997 | Sony Pictures Releasing |
| 281 | Bohemian Rhapsody | $51,061,119 | $216,428,042 | 23.6% | 4,000 | $12,765 | Nov 2, 2018 | Twentieth Century Fox |
| 282 | Prometheus | $51,050,101 | $126,477,084 | 40.4% | 3,396 | $15,032 | Jun 8, 2012 | Twentieth Century Fox |
| 283 | Venom: The Last Dance | $51,012,404 | $128,873,167 | 39.6% | 4,131 | $12,348 | Oct 25, 2024 | Sony Pictures Releasing |
| 284 | Wanted | $50,927,085 | $134,508,551 | 37.9% | 3,175 | $16,040 | Jun 27, 2008 | Universal Pictures |
| 285 | Coco | $50,802,605 | $210,460,015 | 24.1% | 3,987 | $12,742 | Nov 22, 2017 | Walt Disney Studios Motion Pictures |
| 286 | Jurassic Park III | $50,771,645 | $181,171,875 | 28% | 3,434 | $14,784 | Jul 18, 2001 | Universal Pictures |
| 287 | The Village | $50,746,142 | $114,197,520 | 44.4% | 3,730 | $13,604 | Jul 30, 2004 | Walt Disney Studios Motion Pictures |
| 288 | Lightyear | $50,577,961 | $118,307,188 | 42.8% | 4,255 | $11,886 | Jun 17, 2022 | Walt Disney Studios Motion Pictures |
| 289 | Dunkirk | $50,513,488 | $188,045,546 | 26.9% | 3,720 | $13,578 | Jul 21, 2017 | Warner Bros. |
| 290 | 2 Fast 2 Furious | $50,472,480 | $127,154,901 | 39.7% | 3,408 | $14,810 | Jun 6, 2003 | Universal Pictures |
| 291 | Jackass 3D | $50,353,641 | $117,229,692 | 43% | 3,081 | $16,343 | Oct 15, 2010 | Paramount Pictures |
| 292 | Mr. & Mrs. Smith | $50,342,878 | $186,336,279 | 27% | 3,424 | $14,702 | Jun 10, 2005 | Twentieth Century Fox |
| 293 | Rush Hour 3 | $50,237,000 | $140,125,968 | 35.8% | 3,778 | $13,297 | Aug 10, 2007 | New Line Cinema |
| 294 | Independence Day | $50,228,264 | $306,169,268 | 16.4% | 2,882 | $17,428 | Jul 3, 1996 | Twentieth Century Fox |
| 295 | A Quiet Place | $50,203,562 | $188,024,361 | 26.7% | 3,508 | $14,311 | Apr 6, 2018 | Paramount Pictures |
| 296 | The Boss Baby | $50,198,902 | $175,003,033 | 28.7% | 3,773 | $13,304 | Mar 31, 2017 | Twentieth Century Fox |
| 297 | King Kong | $50,130,145 | $218,080,025 | 23% | 3,568 | $14,049 | Dec 14, 2005 | Universal Pictures |
| 298 | The Great Gatsby | $50,085,185 | $144,840,419 | 34.6% | 3,535 | $14,168 | May 10, 2013 | Warner Bros. |
| 299 | It Ends with Us | $50,016,652 | $148,518,266 | 33.7% | 3,611 | $13,851 | Aug 9, 2024 | Sony Pictures Releasing |
| 300 | Scary Movie 3 | $49,700,000 | $110,003,217 | 45.2% | 3,505 | $14,179 | Oct 24, 2003 | Dimension Films |
| 301 | Taken 2 | $49,514,769 | $139,854,287 | 35.4% | 3,661 | $13,524 | Oct 5, 2012 | Twentieth Century Fox |
| 302 | How to Train Your Dragon 2 | $49,451,322 | $177,002,924 | 27.9% | 4,253 | $11,627 | Jun 13, 2014 | Twentieth Century Fox |
| 303 | Halloween Kills | $49,404,980 | $92,002,155 | 53.7% | 3,705 | $13,334 | Oct 15, 2021 | Universal Pictures |
| 304 | Wreck-It Ralph | $49,038,712 | $189,422,889 | 25.9% | 3,752 | $13,070 | Nov 2, 2012 | Walt Disney Studios Motion Pictures |
| 305 | Neighbors | $49,033,915 | $150,157,400 | 32.7% | 3,279 | $14,953 | May 9, 2014 | Universal Pictures |
| 306 | Alvin and the Chipmunks: The Squeakquel | $48,875,415 | $219,614,612 | 22.3% | 3,700 | $13,209 | Dec 23, 2009 | Twentieth Century Fox |
| 307 | Tangled | $48,767,052 | $200,821,936 | 24.3% | 3,603 | $13,535 | Nov 24, 2010 | Walt Disney Studios Motion Pictures |
| 308 | Batman Begins | $48,745,440 | $205,343,774 | 23.7% | 3,858 | $12,634 | Jun 15, 2005 | Warner Bros. |
| 309 | The Matrix Revolutions | $48,475,154 | $139,313,948 | 34.8% | 3,502 | $13,842 | Nov 5, 2003 | Warner Bros. |
| 310 | Hotel Transylvania 2 | $48,464,322 | $169,700,110 | 28.6% | 3,754 | $12,910 | Sep 25, 2015 | Sony Pictures Releasing |
| 311 | The Fault in Our Stars | $48,002,523 | $124,872,350 | 38.4% | 3,173 | $15,128 | Jun 6, 2014 | Twentieth Century Fox |
| 312 | Godzilla: King of the Monsters | $47,776,293 | $110,500,138 | 43.2% | 4,108 | $11,630 | May 31, 2019 | Warner Bros. |
| 313 | Mission: Impossible III | $47,743,273 | $134,029,801 | 35.6% | 4,054 | $11,776 | May 5, 2006 | Paramount Pictures |
| 314 | Lara Croft: Tomb Raider | $47,735,743 | $131,168,070 | 36.4% | 3,308 | $14,430 | Jun 15, 2001 | Paramount Pictures |
| 315 | Kung Fu Panda 2 | $47,656,302 | $165,249,063 | 28.8% | 3,925 | $12,141 | May 26, 2011 | DreamWorks |
| 316 | The Longest Yard | $47,606,480 | $158,119,460 | 30.1% | 3,634 | $13,100 | May 27, 2005 | Paramount Pictures |
| 317 | Shark Tale | $47,604,606 | $160,861,908 | 29.6% | 4,016 | $11,853 | Oct 1, 2004 | DreamWorks Distribution |
| 318 | A Quiet Place Part II | $47,547,231 | $160,072,261 | 29.7% | 3,726 | $12,760 | May 28, 2021 | Paramount Pictures |
| 319 | Interstellar | $47,510,360 | $188,020,017 | 25.3% | 3,561 | $13,341 | Nov 5, 2014 | Paramount Pictures |
| 320 | Madagascar | $47,224,594 | $193,595,521 | 24.4% | 4,131 | $11,431 | May 27, 2005 | DreamWorks Distribution |
| 321 | The Lord of the Rings: The Fellowship of the Ring | $47,211,490 | $313,364,114 | 15.1% | 3,359 | $14,055 | Dec 19, 2001 | New Line Cinema |
| 322 | Die Another Day | $47,072,040 | $160,942,139 | 29.2% | 3,314 | $14,203 | Nov 22, 2002 | Metro-Goldwyn-Mayer (MGM) |
| 323 | Talladega Nights: The Ballad of Ricky Bobby | $47,042,215 | $148,213,377 | 31.7% | 3,803 | $12,369 | Aug 4, 2006 | Sony Pictures Releasing |
| 324 | Ratatouille | $47,027,395 | $206,445,654 | 22.8% | 3,940 | $11,935 | Jun 29, 2007 | Walt Disney Studios Motion Pictures |
| 325 | Jurassic Park | $47,026,828 | $357,067,947 | 13.2% | 2,404 | $19,561 | Jun 11, 1993 | Universal Pictures |
| 326 | Troy | $46,865,412 | $133,378,256 | 35.1% | 3,411 | $13,739 | May 14, 2004 | Warner Bros. |
| 327 | The Secret Life of Pets 2 | $46,652,680 | $158,980,250 | 29.3% | 4,561 | $10,228 | Jun 7, 2019 | Universal Pictures |
| 328 | Pirates of the Caribbean: The Curse of the Black Pearl | $46,630,690 | $305,413,918 | 15.3% | 3,269 | $14,264 | Jul 9, 2003 | Walt Disney Studios Motion Pictures |
| 329 | Ice Age: Continental Drift | $46,629,259 | $161,321,843 | 28.9% | 3,881 | $12,014 | Jul 13, 2012 | Twentieth Century Fox |
| 330 | Fifty Shades Darker | $46,607,250 | $114,581,250 | 40.7% | 3,710 | $12,562 | Feb 10, 2017 | Universal Pictures |
| 331 | Trolls | $46,581,142 | $153,856,089 | 30.3% | 4,060 | $11,473 | Nov 4, 2016 | Twentieth Century Fox |
| 332 | Bad Boys II | $46,522,560 | $138,608,444 | 33.6% | 3,186 | $14,602 | Jul 18, 2003 | Sony Pictures Releasing |
| 333 | Ice Age | $46,312,454 | $176,387,405 | 26.3% | 3,316 | $13,966 | Mar 15, 2002 | Twentieth Century Fox |
| 334 | Angels & Demons | $46,204,168 | $133,375,846 | 34.6% | 3,527 | $13,100 | May 15, 2009 | Sony Pictures Releasing |
| 335 | Meet the Fockers | $46,120,980 | $279,261,160 | 16.5% | 3,518 | $13,110 | Dec 22, 2004 | Universal Pictures |
| 336 | The Marvels | $46,110,859 | $84,500,223 | 54.6% | 4,030 | $11,441 | Nov 10, 2023 | Walt Disney Studios Motion Pictures |
| 337 | Ghostbusters | $46,018,755 | $128,350,574 | 35.8% | 3,963 | $11,612 | Jul 15, 2016 | Sony Pictures Releasing |
| 338 | Megamind | $46,016,833 | $148,415,853 | 31% | 3,944 | $11,667 | Nov 5, 2010 | DreamWorks |
| 339 | Dumbo | $45,990,748 | $114,766,307 | 40.1% | 4,259 | $10,798 | Mar 29, 2019 | Walt Disney Studios Motion Pictures |
| 340 | Batman Returns | $45,687,711 | $162,831,698 | 28.1% | 2,644 | $17,279 | Jun 19, 1992 | Warner Bros. |
| 341 | Mission: Impossible | $45,436,830 | $180,981,856 | 25.1% | 3,012 | $15,085 | May 22, 1996 | Paramount Pictures |
| 342 | Mad Max: Fury Road | $45,428,128 | $153,636,354 | 29.6% | 3,702 | $12,271 | May 15, 2015 | Warner Bros. |
| 343 | The Meg | $45,402,195 | $145,443,742 | 31.2% | 4,118 | $11,025 | Aug 10, 2018 | Warner Bros. |
| 344 | Ghost Rider | $45,388,836 | $115,802,596 | 39.2% | 3,619 | $12,541 | Feb 16, 2007 | Sony Pictures Releasing |
| 345 | American Pie 2 | $45,117,985 | $145,103,595 | 31.1% | 3,063 | $14,729 | Aug 10, 2001 | Universal Pictures |
| 346 | 300: Rise of an Empire | $45,038,460 | $106,580,051 | 42.3% | 3,470 | $12,979 | Mar 7, 2014 | Warner Bros. |
| 347 | Horton Hears a Who! | $45,012,998 | $154,529,439 | 29.1% | 3,954 | $11,384 | Mar 14, 2008 | Twentieth Century Fox |
| 348 | Ghostbusters: Frozen Empire | $45,004,673 | $113,376,590 | 39.7% | 4,345 | $10,357 | Mar 22, 2024 | Sony Pictures Releasing |
| 349 | The Hangover | $44,979,319 | $277,322,503 | 16.2% | 3,269 | $13,759 | Jun 5, 2009 | Warner Bros. |
| 350 | National Treasure: Book of Secrets | $44,783,772 | $219,964,115 | 20.4% | 3,832 | $11,686 | Dec 21, 2007 | Walt Disney Studios Motion Pictures |
| 351 | Transformers: The Last Knight | $44,680,073 | $130,168,683 | 34.3% | 4,069 | $10,980 | Jun 21, 2017 | Paramount Pictures |
| 352 | The Hunger Games: The Ballad of Songbirds & Snakes | $44,607,143 | $166,350,594 | 26.8% | 3,776 | $11,813 | Nov 17, 2023 | Lionsgate |
| 353 | xXx | $44,506,103 | $142,109,382 | 31.3% | 3,374 | $13,190 | Aug 9, 2002 | Revolution Studios |
| 354 | Scream VI | $44,447,270 | $108,161,389 | 41.1% | 3,675 | $12,094 | Mar 10, 2023 | Paramount Pictures |
| 355 | Nope | $44,366,910 | $123,277,080 | 36% | 3,785 | $11,721 | Jul 22, 2022 | Universal Pictures |
| 356 | Alvin and the Chipmunks | $44,307,417 | $217,326,974 | 20.4% | 3,475 | $12,750 | Dec 14, 2007 | Twentieth Century Fox |
| 357 | The Peanuts Movie | $44,213,073 | $130,178,411 | 34% | 3,897 | $11,345 | Nov 6, 2015 | Twentieth Century Fox |
| 358 | Hotel Transylvania 3: Summer Vacation | $44,076,225 | $167,510,016 | 26.3% | 4,267 | $10,329 | Jul 13, 2018 | Sony Pictures Releasing |
| 359 | Godzilla | $44,047,541 | $136,314,294 | 32.3% | 3,310 | $13,307 | May 20, 1998 | Sony Pictures Releasing |
| 360 | Terminator 3: Rise of the Machines | $44,041,440 | $150,371,112 | 29.3% | 3,504 | $12,568 | Jul 2, 2003 | Warner Bros. |
| 361 | TRON: Legacy | $44,026,211 | $172,062,763 | 25.6% | 3,451 | $12,757 | Dec 17, 2010 | Walt Disney Studios Motion Pictures |
| 362 | Uncharted | $44,010,155 | $148,648,820 | 29.6% | 4,275 | $10,294 | Feb 18, 2022 | Sony Pictures Releasing |
| 363 | Ghostbusters: Afterlife | $44,008,406 | $129,360,575 | 34% | 4,315 | $10,198 | Nov 19, 2021 | Sony Pictures Releasing |
| 364 | Lucy | $43,899,340 | $126,663,600 | 34.7% | 3,173 | $13,835 | Jul 25, 2014 | Universal Pictures |
| 365 | How to Train Your Dragon | $43,732,319 | $217,581,231 | 20.1% | 4,055 | $10,784 | Mar 26, 2010 | DreamWorks |
| 366 | Noah | $43,720,472 | $101,200,044 | 43.2% | 3,567 | $12,256 | Mar 28, 2014 | Paramount Pictures |
| 367 | The Croods | $43,639,736 | $187,168,425 | 23.3% | 4,046 | $10,785 | Mar 22, 2013 | Twentieth Century Fox |
| 368 | American Gangster | $43,565,135 | $130,164,645 | 33.5% | 3,054 | $14,264 | Nov 2, 2007 | Universal Pictures |
| 369 | The Mummy | $43,369,635 | $155,516,138 | 27.9% | 3,210 | $13,510 | May 7, 1999 | Universal Pictures |
| 370 | Hitch | $43,142,214 | $179,495,555 | 24% | 3,575 | $12,067 | Feb 11, 2005 | Sony Pictures Releasing |
| 371 | A Star Is Born | $42,908,051 | $215,288,866 | 19.9% | 3,686 | $11,640 | Oct 5, 2018 | Warner Bros. |
| 372 | Batman & Robin | $42,872,605 | $107,325,195 | 40% | 2,934 | $14,612 | Jun 20, 1997 | Warner Bros. |
| 373 | Terminator Salvation | $42,558,390 | $125,322,469 | 34% | 3,530 | $12,056 | May 21, 2009 | Warner Bros. |
| 374 | Hotel Transylvania | $42,522,194 | $148,313,048 | 28.7% | 3,349 | $12,696 | Sep 28, 2012 | Sony Pictures Releasing |
| 375 | Nutty Professor II: The Klumps | $42,518,830 | $123,309,890 | 34.5% | 3,242 | $13,115 | Jul 28, 2000 | Universal Pictures |
| 376 | Shrek | $42,347,760 | $267,851,831 | 15.8% | 3,587 | $11,805 | May 16, 2001 | DreamWorks Distribution |
| 377 | Scary Movie | $42,346,669 | $157,019,771 | 27% | 2,912 | $14,542 | Jul 7, 2000 | Miramax |
| 378 | Anger Management | $42,220,847 | $135,645,823 | 31.1% | 3,551 | $11,889 | Apr 11, 2003 | Revolution Studios |
| 379 | Fantastic Beasts: The Secrets of Dumbledore | $42,151,256 | $95,850,844 | 44% | 4,208 | $10,016 | Apr 15, 2022 | Warner Bros. |
| 380 | High School Musical 3: Senior Year | $42,030,184 | $90,559,416 | 46.4% | 3,623 | $11,600 | Oct 24, 2008 | Walt Disney Studios Motion Pictures |
| 381 | Alien: Romulus | $42,003,361 | $105,313,091 | 39.9% | 3,885 | $10,811 | Aug 16, 2024 | Walt Disney Studios Motion Pictures |
| 382 | The Conjuring | $41,855,326 | $137,400,141 | 30.5% | 2,903 | $14,417 | Jul 19, 2013 | Warner Bros. |
| 383 | Ready Player One | $41,764,050 | $137,690,172 | 30.3% | 4,234 | $9,863 | Mar 29, 2018 | Warner Bros. |
| 384 | Ice Age: Dawn of the Dinosaurs | $41,690,382 | $196,573,705 | 21.2% | 4,099 | $10,170 | Jul 1, 2009 | Twentieth Century Fox |
| 385 | The Hangover Part III | $41,671,198 | $112,200,072 | 37.1% | 3,555 | $11,721 | May 23, 2013 | Warner Bros. |
| 386 | Ocean's Eight | $41,607,378 | $140,218,711 | 29.7% | 4,145 | $10,037 | Jun 8, 2018 | Warner Bros. |
| 387 | Big Daddy | $41,536,370 | $163,479,795 | 25.4% | 3,027 | $13,721 | Jun 25, 1999 | Sony Pictures Releasing |
| 388 | Happy Feet | $41,533,432 | $198,000,317 | 21% | 3,804 | $10,918 | Nov 17, 2006 | Warner Bros. |
| 389 | Ride Along | $41,516,170 | $134,938,200 | 30.8% | 2,663 | $15,590 | Jan 17, 2014 | Universal Pictures |
| 390 | Grown Ups 2 | $41,508,572 | $133,668,525 | 31% | 3,491 | $11,890 | Jul 12, 2013 | Sony Pictures Releasing |
| 391 | The Perfect Storm | $41,325,042 | $182,618,434 | 22.6% | 3,407 | $12,129 | Jun 30, 2000 | Warner Bros. |
| 392 | Kung Fu Panda 3 | $41,282,042 | $143,528,619 | 28.8% | 3,955 | $10,437 | Jan 29, 2016 | Twentieth Century Fox |
| 393 | The Vow | $41,202,458 | $125,014,030 | 33% | 2,958 | $13,929 | Feb 10, 2012 | Screen Gems |
| 394 | Deep Impact | $41,152,375 | $140,464,664 | 29.3% | 3,156 | $13,039 | May 8, 1998 | Paramount Pictures |
| 395 | Once Upon a Time... in Hollywood | $41,082,018 | $142,502,728 | 28.8% | 3,659 | $11,227 | Jul 26, 2019 | Sony Pictures Releasing |
| 396 | Shutter Island | $41,062,440 | $128,012,934 | 32.1% | 2,991 | $13,728 | Feb 19, 2010 | Paramount Pictures |
| 397 | Twister | $41,059,405 | $241,721,524 | 17% | 2,414 | $17,008 | May 10, 1996 | Warner Bros. |
| 398 | Independence Day: Resurgence | $41,039,944 | $103,144,286 | 39.8% | 4,130 | $9,937 | Jun 24, 2016 | Twentieth Century Fox |
| 399 | Madea Goes to Jail | $41,030,947 | $90,508,336 | 45.3% | 2,032 | $20,192 | Feb 20, 2009 | Lionsgate |
| 400 | Dune: Part One | $41,011,174 | $108,327,830 | 37.9% | 4,125 | $9,942 | Oct 22, 2021 | Warner Bros. |
